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Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Asif M - Int J Med Chem (2014)

Bottom Line: Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules.Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities.Being considered as advantaged scaffold, the alteration is made with different substituent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, GRD (PG) Institute of Management and Technology, Dehradun, Uttarakhand 248009, India.

ABSTRACT
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Being considered as advantaged scaffold, the alteration is made with different substituent.

No MeSH data available.


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Related In: Results  -  Collection


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Mentions: The 2,4-diamino-6-[(aryl)thio]quinazoline compounds were known to their antimalarial properties wherein the 4-amino group was replaced by hydrazine and hydroxyamino moieties and they found that such changes reduce markedly the antimalarial properties of this series. The compound (89) was tested against a normal drug-sensitive strain of Plasmodium berghei in mice by the parenteral route [81]. A series of quinazoline derivatives (90) were evaluated for their antiplasmodial activity [82] (see Scheme 65).


Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Asif M - Int J Med Chem (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4321853&req=5

Mentions: The 2,4-diamino-6-[(aryl)thio]quinazoline compounds were known to their antimalarial properties wherein the 4-amino group was replaced by hydrazine and hydroxyamino moieties and they found that such changes reduce markedly the antimalarial properties of this series. The compound (89) was tested against a normal drug-sensitive strain of Plasmodium berghei in mice by the parenteral route [81]. A series of quinazoline derivatives (90) were evaluated for their antiplasmodial activity [82] (see Scheme 65).

Bottom Line: Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules.Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities.Being considered as advantaged scaffold, the alteration is made with different substituent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, GRD (PG) Institute of Management and Technology, Dehradun, Uttarakhand 248009, India.

ABSTRACT
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Being considered as advantaged scaffold, the alteration is made with different substituent.

No MeSH data available.