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Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Asif M - Int J Med Chem (2014)

Bottom Line: Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules.Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities.Being considered as advantaged scaffold, the alteration is made with different substituent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, GRD (PG) Institute of Management and Technology, Dehradun, Uttarakhand 248009, India.

ABSTRACT
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Being considered as advantaged scaffold, the alteration is made with different substituent.

No MeSH data available.


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Mentions: Two regioisomer series, 2-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetylhydrazono)-3-alkyl/3-aryl-5-methyl-4-thiazolidinones (85) and 2-arylimino-3-(3-ethyl-4(3H)-quinazolinone-2-yl mercaptoacetylamino)-5-methyl-4-thiazolidinones were reported for their anticonvulsant activity [77]. Substituted quinazolinonyl-2-Oxo/thiobarbituric acid derivatives showed anticonvulsant activity against MES and scPTZ models [78]. A series of halogenated derivatives, 3-methyl, 3-ethyl and 3-phenyl-6-mono, and 6,8-disubstituted-3H-quinazolin-4-one derivatives exhibited anticonvulsant activity and phenobarbitone sodium was used as a reference drug [79]. Some thiadiazolyl and thiazolidinonyl quinazoline-4(3H)-ones (86) screened them for anticonvulsant activity against MES induced convulsions in animal models [80] (see Scheme 63).


Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Asif M - Int J Med Chem (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4321853&req=5

Mentions: Two regioisomer series, 2-(3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetylhydrazono)-3-alkyl/3-aryl-5-methyl-4-thiazolidinones (85) and 2-arylimino-3-(3-ethyl-4(3H)-quinazolinone-2-yl mercaptoacetylamino)-5-methyl-4-thiazolidinones were reported for their anticonvulsant activity [77]. Substituted quinazolinonyl-2-Oxo/thiobarbituric acid derivatives showed anticonvulsant activity against MES and scPTZ models [78]. A series of halogenated derivatives, 3-methyl, 3-ethyl and 3-phenyl-6-mono, and 6,8-disubstituted-3H-quinazolin-4-one derivatives exhibited anticonvulsant activity and phenobarbitone sodium was used as a reference drug [79]. Some thiadiazolyl and thiazolidinonyl quinazoline-4(3H)-ones (86) screened them for anticonvulsant activity against MES induced convulsions in animal models [80] (see Scheme 63).

Bottom Line: Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules.Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities.Being considered as advantaged scaffold, the alteration is made with different substituent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, GRD (PG) Institute of Management and Technology, Dehradun, Uttarakhand 248009, India.

ABSTRACT
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Being considered as advantaged scaffold, the alteration is made with different substituent.

No MeSH data available.