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Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Asif M - Int J Med Chem (2014)

Bottom Line: Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules.Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities.Being considered as advantaged scaffold, the alteration is made with different substituent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, GRD (PG) Institute of Management and Technology, Dehradun, Uttarakhand 248009, India.

ABSTRACT
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Being considered as advantaged scaffold, the alteration is made with different substituent.

No MeSH data available.


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Mentions: Compound 63a exhibited antiviral activity against herpes simplex virus-1 (KOS), herpes simplex virus-2(G), herpes simplex virus-1 (TK- KOS ACV), and vaccinia virus in HEL cell culture at selectivity index of 100, 100, 100, and 125, respectively, whereas cytotoxicity was observed at 100 μg/mL. Compounds 63b and 63c demonstrated good activity against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), and vaccinia virus. The protein kinase inhibitory activity and anticytomegaloviral activity showed few quinazoline (64) compounds [58]. Quinazolinones act as anti-HIV activity whereas compounds 3-amino-2-methyl mercaptoquinazolin-4(3H)-one (65) were synthesized by condensing the acidic imino group of isatin with formaldehyde and secondary amines and evaluated for anti-HIV activity against HIV-1 III B in MT-4 cells [59] (see Scheme 52).


Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Asif M - Int J Med Chem (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4321853&req=5

Mentions: Compound 63a exhibited antiviral activity against herpes simplex virus-1 (KOS), herpes simplex virus-2(G), herpes simplex virus-1 (TK- KOS ACV), and vaccinia virus in HEL cell culture at selectivity index of 100, 100, 100, and 125, respectively, whereas cytotoxicity was observed at 100 μg/mL. Compounds 63b and 63c demonstrated good activity against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), and vaccinia virus. The protein kinase inhibitory activity and anticytomegaloviral activity showed few quinazoline (64) compounds [58]. Quinazolinones act as anti-HIV activity whereas compounds 3-amino-2-methyl mercaptoquinazolin-4(3H)-one (65) were synthesized by condensing the acidic imino group of isatin with formaldehyde and secondary amines and evaluated for anti-HIV activity against HIV-1 III B in MT-4 cells [59] (see Scheme 52).

Bottom Line: Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules.Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities.Being considered as advantaged scaffold, the alteration is made with different substituent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, GRD (PG) Institute of Management and Technology, Dehradun, Uttarakhand 248009, India.

ABSTRACT
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Being considered as advantaged scaffold, the alteration is made with different substituent.

No MeSH data available.