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Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Asif M - Int J Med Chem (2014)

Bottom Line: Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules.Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities.Being considered as advantaged scaffold, the alteration is made with different substituent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, GRD (PG) Institute of Management and Technology, Dehradun, Uttarakhand 248009, India.

ABSTRACT
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Being considered as advantaged scaffold, the alteration is made with different substituent.

No MeSH data available.


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Mentions: A series of new 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-[(5-substitutedphenyl)-1,5-dihydro-1H-pyrazol-3-yl-amino]-6-iodoquinazolin-4(3H) ones compounds (46) were tested for their antibacterial activity in vitro by measuring zone of inhibition in mm against different strains like two gram positive bacteria, namely, Staphylococcus aureus and Bacillus subtilis, and two gram negative bacteria, namely, Escherichia coli and Certium at two different concentrations 100 μg/mL and 50 μg/mL [40]. Quinazolinone derivatives (DK-1, DK-2, DK-3, DK-4, DK-5, DK-6, and DK-7) by treating 2-chloro-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetamide with the different substituted phenols. The synthesized compounds were evaluated for antibacterial activity by cup plate method by measuring inhibition zone. The compound DK-2 (47) showed more potent antibacterial activity than the standard drug ampicillin [41]. A series of quinazolines derivatives were evaluated for their biological activity on various bacterial cultures [42] (see Schemes 44 and 45).


Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Asif M - Int J Med Chem (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4321853&req=5

Mentions: A series of new 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-[(5-substitutedphenyl)-1,5-dihydro-1H-pyrazol-3-yl-amino]-6-iodoquinazolin-4(3H) ones compounds (46) were tested for their antibacterial activity in vitro by measuring zone of inhibition in mm against different strains like two gram positive bacteria, namely, Staphylococcus aureus and Bacillus subtilis, and two gram negative bacteria, namely, Escherichia coli and Certium at two different concentrations 100 μg/mL and 50 μg/mL [40]. Quinazolinone derivatives (DK-1, DK-2, DK-3, DK-4, DK-5, DK-6, and DK-7) by treating 2-chloro-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetamide with the different substituted phenols. The synthesized compounds were evaluated for antibacterial activity by cup plate method by measuring inhibition zone. The compound DK-2 (47) showed more potent antibacterial activity than the standard drug ampicillin [41]. A series of quinazolines derivatives were evaluated for their biological activity on various bacterial cultures [42] (see Schemes 44 and 45).

Bottom Line: Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules.Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities.Being considered as advantaged scaffold, the alteration is made with different substituent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, GRD (PG) Institute of Management and Technology, Dehradun, Uttarakhand 248009, India.

ABSTRACT
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Being considered as advantaged scaffold, the alteration is made with different substituent.

No MeSH data available.