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Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Asif M - Int J Med Chem (2014)

Bottom Line: Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules.Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities.Being considered as advantaged scaffold, the alteration is made with different substituent.

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Affiliation: Department of Pharmacy, GRD (PG) Institute of Management and Technology, Dehradun, Uttarakhand 248009, India.

ABSTRACT
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Being considered as advantaged scaffold, the alteration is made with different substituent.

No MeSH data available.


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Mentions: Quinazolinones will be classified into the following five categories, based on the substitution patterns of the ring system [3]. These are 2-substituted-4(3H)-quinazolinones, 3-substituted-4(3H)-quinazolinones, 4-substituted-quinazolines, 2,3-disubstituted-4(3H)-quinazolinones, and 2,4-disubstituted-4(3H)-quinazolinones. Depending upon the position of the keto or oxo group, these compounds may be classified into three types [4]. Out of the three (2(1H)quinazolinones, 4(3H)quinazolinones and 2,4(1H,3H)quinazolinedione) quinazolinone structures, 4(3H)-quinazolinones are most prevalent, either as intermediates or as natural products in many proposed biosynthetic pathways (see Scheme 1).


Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Asif M - Int J Med Chem (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4321853&req=5

Mentions: Quinazolinones will be classified into the following five categories, based on the substitution patterns of the ring system [3]. These are 2-substituted-4(3H)-quinazolinones, 3-substituted-4(3H)-quinazolinones, 4-substituted-quinazolines, 2,3-disubstituted-4(3H)-quinazolinones, and 2,4-disubstituted-4(3H)-quinazolinones. Depending upon the position of the keto or oxo group, these compounds may be classified into three types [4]. Out of the three (2(1H)quinazolinones, 4(3H)quinazolinones and 2,4(1H,3H)quinazolinedione) quinazolinone structures, 4(3H)-quinazolinones are most prevalent, either as intermediates or as natural products in many proposed biosynthetic pathways (see Scheme 1).

Bottom Line: Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules.Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities.Being considered as advantaged scaffold, the alteration is made with different substituent.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, GRD (PG) Institute of Management and Technology, Dehradun, Uttarakhand 248009, India.

ABSTRACT
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge consideration owing to their expanded applications in the field of pharmaceutical chemistry. Quinazoline and quinazolinone are reported for their diversified biological activities and compounds with different substitutions bring together to knowledge of a target with understanding of the molecule types that might interact with the target receptors. Quinazolines and quinazolinones are considered as an important chemical for the synthesis of various physiological significance and pharmacological utilized molecules. Quinazolines and quinazolinone are a large class of biologically active compounds that exhibited broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Being considered as advantaged scaffold, the alteration is made with different substituent.

No MeSH data available.