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White matter hyperintensities and normal-appearing white matter integrity in the aging brain.

Maniega SM, Valdés Hernández MC, Clayden JD, Royle NA, Murray C, Morris Z, Aribisala BS, Gow AJ, Starr JM, Bastin ME, Deary IJ, Wardlaw JM - Neurobiol. Aging (2014)

Bottom Line: Fractional anisotropy (FA) and magnetization transfer ratio (MTR) were significantly lower, whereas mean diffusivity (MD) and longitudinal relaxation time (T1) were significantly higher, in WMH than NAWM (p < 0.0001), with MD providing the largest difference between NAWM and WMH.Furthermore, the level of deterioration of NAWM was strongly associated with the severity of WMH, with MD and T1 increasing and FA and MTR decreasing in NAWM with increasing WMH score, a relationship that was sustained regardless of distance from the WMH.These multimodal imaging data indicate that WMH have reduced structural integrity compared with surrounding NAWM, and MD provides the best discriminator between the 2 tissue classes even within the mild range of WMH severity, whereas FA, MTR, and T1 only start reflecting significant changes in tissue microstructure as WMH become more severe.

View Article: PubMed Central - PubMed

Affiliation: Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK; Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK; Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), University of Edinburgh, Edinburgh, UK.

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Box plots of NAWM measured in ROI contouring WMH at (approximate) distances between 2 mm and 10 mm, as well and the remaining NAWM, with data divided by Fazekas score as indicated by different color boxes. The data for WMH are included for reference. Abbreviations: NAWM, normal-appearing white matter; ROI, region of interest; WMH, white matter hyperintensity. (For interpretation of the references to color in this Figure, the reader is referred to the web version of this article.)
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fig6: Box plots of NAWM measured in ROI contouring WMH at (approximate) distances between 2 mm and 10 mm, as well and the remaining NAWM, with data divided by Fazekas score as indicated by different color boxes. The data for WMH are included for reference. Abbreviations: NAWM, normal-appearing white matter; ROI, region of interest; WMH, white matter hyperintensity. (For interpretation of the references to color in this Figure, the reader is referred to the web version of this article.)

Mentions: Fig. 5 shows the box plots of the imaging biomarkers measured in NAWM at a range of distances from the WMH for all participants. Data for the WMH are included for reference. Both MD and T1 decrease with distance from the WMH, whereas MTR increases. FA shows a slight increase when moving from 2 mm to 4 mm; however, it decreases thereafter. Fig. 6 shows the same data divided by total Fazekas scores; the changes with distance are the same as in Fig. 5 for all Fazekas scores. The pattern of changes of NAWM biomarkers with lesion load also does not vary with distance, as the pattern shown in Fig. 4B remains consistent for the ROI surrounding the WMH, as shown in Fig. 6. The analysis of the small ROI that sampled the same small points in NAWM of each participant confirmed that change in NAWM with Fazekas score was not simply because of variation in underlying FA by location of remaining NAWM (Supplementary Material).


White matter hyperintensities and normal-appearing white matter integrity in the aging brain.

Maniega SM, Valdés Hernández MC, Clayden JD, Royle NA, Murray C, Morris Z, Aribisala BS, Gow AJ, Starr JM, Bastin ME, Deary IJ, Wardlaw JM - Neurobiol. Aging (2014)

Box plots of NAWM measured in ROI contouring WMH at (approximate) distances between 2 mm and 10 mm, as well and the remaining NAWM, with data divided by Fazekas score as indicated by different color boxes. The data for WMH are included for reference. Abbreviations: NAWM, normal-appearing white matter; ROI, region of interest; WMH, white matter hyperintensity. (For interpretation of the references to color in this Figure, the reader is referred to the web version of this article.)
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4321830&req=5

fig6: Box plots of NAWM measured in ROI contouring WMH at (approximate) distances between 2 mm and 10 mm, as well and the remaining NAWM, with data divided by Fazekas score as indicated by different color boxes. The data for WMH are included for reference. Abbreviations: NAWM, normal-appearing white matter; ROI, region of interest; WMH, white matter hyperintensity. (For interpretation of the references to color in this Figure, the reader is referred to the web version of this article.)
Mentions: Fig. 5 shows the box plots of the imaging biomarkers measured in NAWM at a range of distances from the WMH for all participants. Data for the WMH are included for reference. Both MD and T1 decrease with distance from the WMH, whereas MTR increases. FA shows a slight increase when moving from 2 mm to 4 mm; however, it decreases thereafter. Fig. 6 shows the same data divided by total Fazekas scores; the changes with distance are the same as in Fig. 5 for all Fazekas scores. The pattern of changes of NAWM biomarkers with lesion load also does not vary with distance, as the pattern shown in Fig. 4B remains consistent for the ROI surrounding the WMH, as shown in Fig. 6. The analysis of the small ROI that sampled the same small points in NAWM of each participant confirmed that change in NAWM with Fazekas score was not simply because of variation in underlying FA by location of remaining NAWM (Supplementary Material).

Bottom Line: Fractional anisotropy (FA) and magnetization transfer ratio (MTR) were significantly lower, whereas mean diffusivity (MD) and longitudinal relaxation time (T1) were significantly higher, in WMH than NAWM (p < 0.0001), with MD providing the largest difference between NAWM and WMH.Furthermore, the level of deterioration of NAWM was strongly associated with the severity of WMH, with MD and T1 increasing and FA and MTR decreasing in NAWM with increasing WMH score, a relationship that was sustained regardless of distance from the WMH.These multimodal imaging data indicate that WMH have reduced structural integrity compared with surrounding NAWM, and MD provides the best discriminator between the 2 tissue classes even within the mild range of WMH severity, whereas FA, MTR, and T1 only start reflecting significant changes in tissue microstructure as WMH become more severe.

View Article: PubMed Central - PubMed

Affiliation: Brain Research Imaging Centre, Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK; Scottish Imaging Network: A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, UK; Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), University of Edinburgh, Edinburgh, UK.

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Related in: MedlinePlus