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Neuroprotective effect of gui zhi (ramulus cinnamomi) on ma huang- (herb ephedra-) induced toxicity in rats treated with a ma huang-gui zhi herb pair.

Zheng FH, Wei P, Huo HL, Xing XF, Chen FL, Tan XM, Luo JB - Evid Based Complement Alternat Med (2015)

Bottom Line: Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted.After 7 days, oxidative damage in the prefrontal cortex was measured.Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang.

View Article: PubMed Central - PubMed

Affiliation: School of Chinese Medical Sciences, Southern Medical University, 510515 Guangzhou, China.

ABSTRACT
Herb Ephedra (Ma Huang in Chinese) and Ramulus Cinnamomi (Gui Zhi in Chinese) are traditional Chinese herbs, often used together to treat asthma, nose and lung congestion, and fever with anhidrosis. Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted. However, Gui Zhi extract has been reported to decrease spontaneous activity in rats and exert anti-inflammatory and neuroprotective effects. The present study explored the possible inhibitory effect of Gui Zhi on Ma Huang-induced neurotoxicity in rats when the two herbs were used in combination. All Ma Huang and Ma Huang-Gui Zhi herb pair extracts were prepared using methods of traditional Chinese medicine and were normalized based on the ephedrine content. Two-month-old male Sprague-Dawley rats (n = 6 rats/group) were administered Ma Huang or the Ma Huang-Gui Zhi herb pair extracts for 7 days (ephedrine = 48 mg/kg), and locomotor activity was measured. After 7 days, oxidative damage in the prefrontal cortex was measured. Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang. The results of this study demonstrate the neuroprotective potential of Gui Zhi in Ma Huang-induced hyperactivity and oxidative damage in the prefrontal cortex of rats when used in combination.

No MeSH data available.


Related in: MedlinePlus

Each bar represents the mean ± SEM of six rats. *P < 0.05, **P < 0.01 indicates a significant difference compared to the saline treated group; #P < 0.05, ##P < 0.01 indicates a significant difference compared to E-treated rats (ANOVA).
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fig4: Each bar represents the mean ± SEM of six rats. *P < 0.05, **P < 0.01 indicates a significant difference compared to the saline treated group; #P < 0.05, ##P < 0.01 indicates a significant difference compared to E-treated rats (ANOVA).

Mentions: The total SOD, CAT, and GSH-Px activity in the prefrontal cortex of E-treated rats was significantly lower than that of the saline group (P < 0.01) (Figure 4). However, Gui Zhi counteracted the effects of Ma Huang on SOD, CAT, and GSH-Px in the W1-, W2-, and W3-treated groups. In rats treated with W3, SOD, and CAT activities remained at normal levels.


Neuroprotective effect of gui zhi (ramulus cinnamomi) on ma huang- (herb ephedra-) induced toxicity in rats treated with a ma huang-gui zhi herb pair.

Zheng FH, Wei P, Huo HL, Xing XF, Chen FL, Tan XM, Luo JB - Evid Based Complement Alternat Med (2015)

Each bar represents the mean ± SEM of six rats. *P < 0.05, **P < 0.01 indicates a significant difference compared to the saline treated group; #P < 0.05, ##P < 0.01 indicates a significant difference compared to E-treated rats (ANOVA).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4321680&req=5

fig4: Each bar represents the mean ± SEM of six rats. *P < 0.05, **P < 0.01 indicates a significant difference compared to the saline treated group; #P < 0.05, ##P < 0.01 indicates a significant difference compared to E-treated rats (ANOVA).
Mentions: The total SOD, CAT, and GSH-Px activity in the prefrontal cortex of E-treated rats was significantly lower than that of the saline group (P < 0.01) (Figure 4). However, Gui Zhi counteracted the effects of Ma Huang on SOD, CAT, and GSH-Px in the W1-, W2-, and W3-treated groups. In rats treated with W3, SOD, and CAT activities remained at normal levels.

Bottom Line: Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted.After 7 days, oxidative damage in the prefrontal cortex was measured.Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang.

View Article: PubMed Central - PubMed

Affiliation: School of Chinese Medical Sciences, Southern Medical University, 510515 Guangzhou, China.

ABSTRACT
Herb Ephedra (Ma Huang in Chinese) and Ramulus Cinnamomi (Gui Zhi in Chinese) are traditional Chinese herbs, often used together to treat asthma, nose and lung congestion, and fever with anhidrosis. Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted. However, Gui Zhi extract has been reported to decrease spontaneous activity in rats and exert anti-inflammatory and neuroprotective effects. The present study explored the possible inhibitory effect of Gui Zhi on Ma Huang-induced neurotoxicity in rats when the two herbs were used in combination. All Ma Huang and Ma Huang-Gui Zhi herb pair extracts were prepared using methods of traditional Chinese medicine and were normalized based on the ephedrine content. Two-month-old male Sprague-Dawley rats (n = 6 rats/group) were administered Ma Huang or the Ma Huang-Gui Zhi herb pair extracts for 7 days (ephedrine = 48 mg/kg), and locomotor activity was measured. After 7 days, oxidative damage in the prefrontal cortex was measured. Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang. The results of this study demonstrate the neuroprotective potential of Gui Zhi in Ma Huang-induced hyperactivity and oxidative damage in the prefrontal cortex of rats when used in combination.

No MeSH data available.


Related in: MedlinePlus