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General analytical procedure for determination of acidity parameters of weak acids and bases.

Pilarski B, Kaliszan R, Wyrzykowski D, Młodzianowski J, Balińska A - J Anal Methods Chem (2015)

Bottom Line: The paper presents a new convenient, inexpensive, and reagent-saving general methodology for the determination of pK a values for components of the mixture of diverse chemical classes weak organic acids and bases in water solution, without the need to separate individual analytes.The data obtained from simple pH-metric microtitrations are numerically processed into reliable pK a values for each component of the mixture.Excellent agreement has been obtained between the determined pK a values and the reference literature data for compounds studied.

View Article: PubMed Central - PubMed

Affiliation: Cerko Sp. z o.o. Sp.K, Al. Zwycięstwa 96/98, 81-451 Gdynia, Poland.

ABSTRACT
The paper presents a new convenient, inexpensive, and reagent-saving general methodology for the determination of pK a values for components of the mixture of diverse chemical classes weak organic acids and bases in water solution, without the need to separate individual analytes. The data obtained from simple pH-metric microtitrations are numerically processed into reliable pK a values for each component of the mixture. Excellent agreement has been obtained between the determined pK a values and the reference literature data for compounds studied.

No MeSH data available.


Plot of experimental versus literature pKa's values for the compounds under study.
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Related In: Results  -  Collection


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fig3: Plot of experimental versus literature pKa's values for the compounds under study.

Mentions: A new approach for studying equilibrium constants for the dissociation of different types of weak electrolytes present in a mixture of any degree of complexity has been proposed. Potentiometric titration technique and numerical procedure based on an original algorithm elaborated by Kostrowicki and Liwo and adopted in the Cerko Lab software have successfully been applied to obtain the pKa values of a variety of classes of compounds comprising of common organic acids and bases, amino acids, phenols and enols OH-acids, and heterocyclic N–H-acids as well as compounds of pharmaceutical importance. It was shown that the pKa values of the compound present in the mixture can be determined directly without the need to separate individual analytes. The obtained pKa values of the electrolytes under study are in a good agreement with those reported in the literature (Table 11, Figure 3). Thus, the presented methodology can be considered as a fast, simple, inexpensive, and reagents-saving way for studying equilibria in the mixture of electrolytes. Moreover, it does not require a highly trained personnel. The methodology described in this paper can be routinely used in a regular analytical practice.


General analytical procedure for determination of acidity parameters of weak acids and bases.

Pilarski B, Kaliszan R, Wyrzykowski D, Młodzianowski J, Balińska A - J Anal Methods Chem (2015)

Plot of experimental versus literature pKa's values for the compounds under study.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4321670&req=5

fig3: Plot of experimental versus literature pKa's values for the compounds under study.
Mentions: A new approach for studying equilibrium constants for the dissociation of different types of weak electrolytes present in a mixture of any degree of complexity has been proposed. Potentiometric titration technique and numerical procedure based on an original algorithm elaborated by Kostrowicki and Liwo and adopted in the Cerko Lab software have successfully been applied to obtain the pKa values of a variety of classes of compounds comprising of common organic acids and bases, amino acids, phenols and enols OH-acids, and heterocyclic N–H-acids as well as compounds of pharmaceutical importance. It was shown that the pKa values of the compound present in the mixture can be determined directly without the need to separate individual analytes. The obtained pKa values of the electrolytes under study are in a good agreement with those reported in the literature (Table 11, Figure 3). Thus, the presented methodology can be considered as a fast, simple, inexpensive, and reagents-saving way for studying equilibria in the mixture of electrolytes. Moreover, it does not require a highly trained personnel. The methodology described in this paper can be routinely used in a regular analytical practice.

Bottom Line: The paper presents a new convenient, inexpensive, and reagent-saving general methodology for the determination of pK a values for components of the mixture of diverse chemical classes weak organic acids and bases in water solution, without the need to separate individual analytes.The data obtained from simple pH-metric microtitrations are numerically processed into reliable pK a values for each component of the mixture.Excellent agreement has been obtained between the determined pK a values and the reference literature data for compounds studied.

View Article: PubMed Central - PubMed

Affiliation: Cerko Sp. z o.o. Sp.K, Al. Zwycięstwa 96/98, 81-451 Gdynia, Poland.

ABSTRACT
The paper presents a new convenient, inexpensive, and reagent-saving general methodology for the determination of pK a values for components of the mixture of diverse chemical classes weak organic acids and bases in water solution, without the need to separate individual analytes. The data obtained from simple pH-metric microtitrations are numerically processed into reliable pK a values for each component of the mixture. Excellent agreement has been obtained between the determined pK a values and the reference literature data for compounds studied.

No MeSH data available.