Limits...
Associated bone mineral density and obstructive sleep apnea in chronic obstructive pulmonary disease.

Wang TY, Lo YL, Chou PC, Chung FT, Lin SM, Lin TY, Lin HC, Wang CH, Yu CT, Kuo HP - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: The BMD in those with OSA was significantly lower than in those without OSA (-1.99±1.63 versus -1.27±1.14, P=0.045).In univariate analysis, body mass index, forced expiratory volume in 1 second, percentage of predicted value, incremental shuttle walk test, apnea-hypopnea index, and oxygen desaturation index (ODI) were significantly associated with BMD.In addition, smaller total lung capacity is significantly associated with higher ODI and lower BMD, which implies that lower BMD might cause severer OSA via decreased total lung capacity.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Medicine, School of Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan.

ABSTRACT

Background: Osteoporosis is an important issue for patients with chronic obstructive pulmonary disease (COPD). Worse systemic inflammation and reduced exercise capacity have been reported in COPD patients with obstructive sleep apnea (OSA), implying that OSA may be an independent factor for osteoporosis in COPD patients.

Methods: A total of 66 patients with bone mineral density (BMD) and polysomnography results from a previous COPD cohort (January 2008 to January 2013) were retrospectively enrolled. Clinical characteristics such as medication, pulmonary function, BMD, and results of polysomnography were analyzed.

Results: The BMD in those with OSA was significantly lower than in those without OSA (-1.99±1.63 versus -1.27±1.14, P=0.045). In univariate analysis, body mass index, forced expiratory volume in 1 second, percentage of predicted value, incremental shuttle walk test, apnea-hypopnea index, and oxygen desaturation index (ODI) were significantly associated with BMD. After multivariate linear regression analysis, the ODI was still an independent factor for BMD. In addition, smaller total lung capacity is significantly associated with higher ODI and lower BMD, which implies that lower BMD might cause severer OSA via decreased total lung capacity.

Conclusion: OSA may be an independent factor for BMD in patients with COPD, which implies a possible vicious cycle takes place in these patients.

Show MeSH

Related in: MedlinePlus

Correlation analysis: an association between bone mineral density and apnea–hypopnea index.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4321657&req=5

f1-copd-10-231: Correlation analysis: an association between bone mineral density and apnea–hypopnea index.

Mentions: In univariate analysis, body mass index (BMI), FEV1 %, ISWT, AHI, and oxygen desaturation index (ODI) (Figure 1) were significantly correlated with BMD at the lumbar spine (Table 3), while age and use of inhaled corticosteroids, oral corticosteroids, and proton pump inhibitors were not. The multivariate stepwise linear regression analysis was used to analyze the independent factors contributing to BMD (Table 4). The association between BMD and AHI is revealed in Figure 1. Although, BMI, FEV1 %, ISWT, AHI, and ODI were chosen to be analyzed in multivariate stepwise linear regression, only BMI, FEV1 %, and ODI were independent factors for BMD.


Associated bone mineral density and obstructive sleep apnea in chronic obstructive pulmonary disease.

Wang TY, Lo YL, Chou PC, Chung FT, Lin SM, Lin TY, Lin HC, Wang CH, Yu CT, Kuo HP - Int J Chron Obstruct Pulmon Dis (2015)

Correlation analysis: an association between bone mineral density and apnea–hypopnea index.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4321657&req=5

f1-copd-10-231: Correlation analysis: an association between bone mineral density and apnea–hypopnea index.
Mentions: In univariate analysis, body mass index (BMI), FEV1 %, ISWT, AHI, and oxygen desaturation index (ODI) (Figure 1) were significantly correlated with BMD at the lumbar spine (Table 3), while age and use of inhaled corticosteroids, oral corticosteroids, and proton pump inhibitors were not. The multivariate stepwise linear regression analysis was used to analyze the independent factors contributing to BMD (Table 4). The association between BMD and AHI is revealed in Figure 1. Although, BMI, FEV1 %, ISWT, AHI, and ODI were chosen to be analyzed in multivariate stepwise linear regression, only BMI, FEV1 %, and ODI were independent factors for BMD.

Bottom Line: The BMD in those with OSA was significantly lower than in those without OSA (-1.99±1.63 versus -1.27±1.14, P=0.045).In univariate analysis, body mass index, forced expiratory volume in 1 second, percentage of predicted value, incremental shuttle walk test, apnea-hypopnea index, and oxygen desaturation index (ODI) were significantly associated with BMD.In addition, smaller total lung capacity is significantly associated with higher ODI and lower BMD, which implies that lower BMD might cause severer OSA via decreased total lung capacity.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Medicine, School of Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan.

ABSTRACT

Background: Osteoporosis is an important issue for patients with chronic obstructive pulmonary disease (COPD). Worse systemic inflammation and reduced exercise capacity have been reported in COPD patients with obstructive sleep apnea (OSA), implying that OSA may be an independent factor for osteoporosis in COPD patients.

Methods: A total of 66 patients with bone mineral density (BMD) and polysomnography results from a previous COPD cohort (January 2008 to January 2013) were retrospectively enrolled. Clinical characteristics such as medication, pulmonary function, BMD, and results of polysomnography were analyzed.

Results: The BMD in those with OSA was significantly lower than in those without OSA (-1.99±1.63 versus -1.27±1.14, P=0.045). In univariate analysis, body mass index, forced expiratory volume in 1 second, percentage of predicted value, incremental shuttle walk test, apnea-hypopnea index, and oxygen desaturation index (ODI) were significantly associated with BMD. After multivariate linear regression analysis, the ODI was still an independent factor for BMD. In addition, smaller total lung capacity is significantly associated with higher ODI and lower BMD, which implies that lower BMD might cause severer OSA via decreased total lung capacity.

Conclusion: OSA may be an independent factor for BMD in patients with COPD, which implies a possible vicious cycle takes place in these patients.

Show MeSH
Related in: MedlinePlus