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Autistic empathy toward autistic others.

Komeda H, Kosaka H, Saito DN, Mano Y, Jung M, Fujii T, Yanaka HT, Munesue T, Ishitobi M, Sato M, Okazawa H - Soc Cogn Affect Neurosci (2014)

Bottom Line: The results demonstrated that the ventromedial prefrontal cortex was significantly activated in individuals with ASD in response to autistic characters and in TD individuals in response to non-autistic characters.Although the frontal-posterior network between the ventromedial prefrontal cortex and superior temporal gyrus participated in the processing of non-autistic characters in TD individuals, an alternative network was involved when individuals with ASD processed autistic characters.This suggests an atypical form of empathy in individuals with ASD toward others with ASD.

View Article: PubMed Central - PubMed

Affiliation: The Hakubi Center for Advanced Research, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan, Research Center for Child Mental Development, University of Fukui, Fukui 910-1193, Japan, Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan, Division of Developmental Higher Brain Functions, Department of Child Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Fukui 910-1193, Japan, Biomedical Imaging Research Center, University of Fukui, Fukui 910-1193, Japan, Department of Psychology, Northwestern University, Evanston, IL 60208-2710, USA, Department of Psychiatry, National Center of Neurology and Psychiatry Hospital, 4-1-1, Ogawahigashi, Kodaira, Tokyo 187-8551, Japan, Faculty of Regional Sciences, Tottori University, Koyamacho-Minami, Tottori City 680-8551, Japan, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan, Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8553, Japan, Division of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan, and Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan komeda.hidetsugu.5w@kyoto-u.ac.jp.

No MeSH data available.


Related in: MedlinePlus

(A) Brain activation in self- and other judgments. P < 0.001, uncorrected at the voxel level for a spatial extent of at least 10 voxels. vmPFC (4, 48, −8) activation based on the interaction between group and character. (B) The mean for parameter estimates at the cluster denoting vmPFC activation based on the interaction between group and character (autistic characters for the ASD group and non-autistic characters for the TD group). Dark orange bars denote judgments for autistic characters; light blue bars denote judgments for non-autistic characters. Error bars indicate standard errors. *P < 0.05. (C) Plots of correlations (r = 0.43, P < 0.05) between AQ scores and vmPFC activation during judgments for autistic characters in the interaction between group and character. Black circles indicate individuals with ASD (n = 15); white circles indicate TD individuals (n = 15).
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nsu126-F3: (A) Brain activation in self- and other judgments. P < 0.001, uncorrected at the voxel level for a spatial extent of at least 10 voxels. vmPFC (4, 48, −8) activation based on the interaction between group and character. (B) The mean for parameter estimates at the cluster denoting vmPFC activation based on the interaction between group and character (autistic characters for the ASD group and non-autistic characters for the TD group). Dark orange bars denote judgments for autistic characters; light blue bars denote judgments for non-autistic characters. Error bars indicate standard errors. *P < 0.05. (C) Plots of correlations (r = 0.43, P < 0.05) between AQ scores and vmPFC activation during judgments for autistic characters in the interaction between group and character. Black circles indicate individuals with ASD (n = 15); white circles indicate TD individuals (n = 15).

Mentions: We investigated the brain activation associated with the interaction between group and character (Table 3). Results were thresholded at P < 0.001 (uncorrected) for a spatial extent of at least 10 voxels. The inferior frontal gyrus (IFG), postcentral gyrus, paracentral lobule, precuneus, cuneus, lingual gyrus, cerebellum, fusiform and superior frontal gyrus and vmPFC were activated in both groups when the ASD group judged characters with and the TD group judged characters without autistic traits (Figure 3A and B). Post hoc tests were performed on the parameter estimates.Fig. 3


Autistic empathy toward autistic others.

Komeda H, Kosaka H, Saito DN, Mano Y, Jung M, Fujii T, Yanaka HT, Munesue T, Ishitobi M, Sato M, Okazawa H - Soc Cogn Affect Neurosci (2014)

(A) Brain activation in self- and other judgments. P < 0.001, uncorrected at the voxel level for a spatial extent of at least 10 voxels. vmPFC (4, 48, −8) activation based on the interaction between group and character. (B) The mean for parameter estimates at the cluster denoting vmPFC activation based on the interaction between group and character (autistic characters for the ASD group and non-autistic characters for the TD group). Dark orange bars denote judgments for autistic characters; light blue bars denote judgments for non-autistic characters. Error bars indicate standard errors. *P < 0.05. (C) Plots of correlations (r = 0.43, P < 0.05) between AQ scores and vmPFC activation during judgments for autistic characters in the interaction between group and character. Black circles indicate individuals with ASD (n = 15); white circles indicate TD individuals (n = 15).
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4321632&req=5

nsu126-F3: (A) Brain activation in self- and other judgments. P < 0.001, uncorrected at the voxel level for a spatial extent of at least 10 voxels. vmPFC (4, 48, −8) activation based on the interaction between group and character. (B) The mean for parameter estimates at the cluster denoting vmPFC activation based on the interaction between group and character (autistic characters for the ASD group and non-autistic characters for the TD group). Dark orange bars denote judgments for autistic characters; light blue bars denote judgments for non-autistic characters. Error bars indicate standard errors. *P < 0.05. (C) Plots of correlations (r = 0.43, P < 0.05) between AQ scores and vmPFC activation during judgments for autistic characters in the interaction between group and character. Black circles indicate individuals with ASD (n = 15); white circles indicate TD individuals (n = 15).
Mentions: We investigated the brain activation associated with the interaction between group and character (Table 3). Results were thresholded at P < 0.001 (uncorrected) for a spatial extent of at least 10 voxels. The inferior frontal gyrus (IFG), postcentral gyrus, paracentral lobule, precuneus, cuneus, lingual gyrus, cerebellum, fusiform and superior frontal gyrus and vmPFC were activated in both groups when the ASD group judged characters with and the TD group judged characters without autistic traits (Figure 3A and B). Post hoc tests were performed on the parameter estimates.Fig. 3

Bottom Line: The results demonstrated that the ventromedial prefrontal cortex was significantly activated in individuals with ASD in response to autistic characters and in TD individuals in response to non-autistic characters.Although the frontal-posterior network between the ventromedial prefrontal cortex and superior temporal gyrus participated in the processing of non-autistic characters in TD individuals, an alternative network was involved when individuals with ASD processed autistic characters.This suggests an atypical form of empathy in individuals with ASD toward others with ASD.

View Article: PubMed Central - PubMed

Affiliation: The Hakubi Center for Advanced Research, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan, Research Center for Child Mental Development, University of Fukui, Fukui 910-1193, Japan, Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan, Division of Developmental Higher Brain Functions, Department of Child Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Fukui 910-1193, Japan, Biomedical Imaging Research Center, University of Fukui, Fukui 910-1193, Japan, Department of Psychology, Northwestern University, Evanston, IL 60208-2710, USA, Department of Psychiatry, National Center of Neurology and Psychiatry Hospital, 4-1-1, Ogawahigashi, Kodaira, Tokyo 187-8551, Japan, Faculty of Regional Sciences, Tottori University, Koyamacho-Minami, Tottori City 680-8551, Japan, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan, Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8553, Japan, Division of Developmental Neuroscience, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan, and Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan komeda.hidetsugu.5w@kyoto-u.ac.jp.

No MeSH data available.


Related in: MedlinePlus