Limits...
Nanomedicine strategies for treatment of secondary spinal cord injury.

White-Schenk D, Shi R, Leary JF - Int J Nanomedicine (2015)

Bottom Line: Therefore, the mitigation of such a cascade would benefit patients suffering a primary injury and allow the body to recover more quickly.Unfortunately, the delivery of effective therapeutics is quite limited.Due to the inefficient delivery of therapeutic drugs, nanoparticles have become a major field of exploration for medical applications.

View Article: PubMed Central - PubMed

Affiliation: Interdisciplinary Biomedical Sciences Program, Purdue University, West Lafayette, IN, USA ; Birck Nanotechnology Center, Discovery Park, Purdue University, West Lafayette, IN, USA.

ABSTRACT
Neurological injury, such as spinal cord injury, has a secondary injury associated with it. The secondary injury results from the biological cascade after the primary injury and affects previous uninjured, healthy tissue. Therefore, the mitigation of such a cascade would benefit patients suffering a primary injury and allow the body to recover more quickly. Unfortunately, the delivery of effective therapeutics is quite limited. Due to the inefficient delivery of therapeutic drugs, nanoparticles have become a major field of exploration for medical applications. Based on their material properties, they can help treat disease by delivering drugs to specific tissues, enhancing detection methods, or a mixture of both. Incorporating nanomedicine into the treatment of neuronal injury and disease would likely push nanomedicine into a new light. This review highlights the various pathological issues involved in secondary spinal cord injury, current treatment options, and the improvements that could be made using a nanomedical approach.

No MeSH data available.


Related in: MedlinePlus

Progression of primary injury and secondary injury. After primary injury, the biochemical cascade that follows is secondary injury. The secondary injury can cause damage to tissue that was previously unharmed, perpetuating a cycle of oxidative stress and injury.Abbreviation: ROS, reactive oxygen species.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4321603&req=5

f2-ijn-10-923: Progression of primary injury and secondary injury. After primary injury, the biochemical cascade that follows is secondary injury. The secondary injury can cause damage to tissue that was previously unharmed, perpetuating a cycle of oxidative stress and injury.Abbreviation: ROS, reactive oxygen species.

Mentions: In SCI, inflammation plays a role in the health and progression of CNS neurons. In vitro, activated microglial cells induce oxidative stress when cultured with neuronal cells.34,35 Although the response is natural, the oxidative stress can be detrimental to cells that are already undergoing stress. Figure 2 highlights the role inflammation can have in neuronal injury.


Nanomedicine strategies for treatment of secondary spinal cord injury.

White-Schenk D, Shi R, Leary JF - Int J Nanomedicine (2015)

Progression of primary injury and secondary injury. After primary injury, the biochemical cascade that follows is secondary injury. The secondary injury can cause damage to tissue that was previously unharmed, perpetuating a cycle of oxidative stress and injury.Abbreviation: ROS, reactive oxygen species.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4321603&req=5

f2-ijn-10-923: Progression of primary injury and secondary injury. After primary injury, the biochemical cascade that follows is secondary injury. The secondary injury can cause damage to tissue that was previously unharmed, perpetuating a cycle of oxidative stress and injury.Abbreviation: ROS, reactive oxygen species.
Mentions: In SCI, inflammation plays a role in the health and progression of CNS neurons. In vitro, activated microglial cells induce oxidative stress when cultured with neuronal cells.34,35 Although the response is natural, the oxidative stress can be detrimental to cells that are already undergoing stress. Figure 2 highlights the role inflammation can have in neuronal injury.

Bottom Line: Therefore, the mitigation of such a cascade would benefit patients suffering a primary injury and allow the body to recover more quickly.Unfortunately, the delivery of effective therapeutics is quite limited.Due to the inefficient delivery of therapeutic drugs, nanoparticles have become a major field of exploration for medical applications.

View Article: PubMed Central - PubMed

Affiliation: Interdisciplinary Biomedical Sciences Program, Purdue University, West Lafayette, IN, USA ; Birck Nanotechnology Center, Discovery Park, Purdue University, West Lafayette, IN, USA.

ABSTRACT
Neurological injury, such as spinal cord injury, has a secondary injury associated with it. The secondary injury results from the biological cascade after the primary injury and affects previous uninjured, healthy tissue. Therefore, the mitigation of such a cascade would benefit patients suffering a primary injury and allow the body to recover more quickly. Unfortunately, the delivery of effective therapeutics is quite limited. Due to the inefficient delivery of therapeutic drugs, nanoparticles have become a major field of exploration for medical applications. Based on their material properties, they can help treat disease by delivering drugs to specific tissues, enhancing detection methods, or a mixture of both. Incorporating nanomedicine into the treatment of neuronal injury and disease would likely push nanomedicine into a new light. This review highlights the various pathological issues involved in secondary spinal cord injury, current treatment options, and the improvements that could be made using a nanomedical approach.

No MeSH data available.


Related in: MedlinePlus