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Correlation of bone morphogenetic protein-2 levels in serum and synovial fluid with disease severity of knee osteoarthritis.

Liu Y, Hou R, Yin R, Yin W - Med. Sci. Monit. (2015)

Bottom Line: This study aimed to investigate the bone morphogenetic protein-2 (BMP-2) levels in serum and synovial fluid (SF) of patients with primary knee osteoarthritis (OA) and to exam its correlation with radiographic and symptomatic severity of the disease.Symptomatic severity of the disease was evaluated according to the Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores.BMP-2 levels in serum and SF were determined using enzyme-linked immunosorbent assay.

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasonography, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China (mainland).

ABSTRACT

Background: This study aimed to investigate the bone morphogenetic protein-2 (BMP-2) levels in serum and synovial fluid (SF) of patients with primary knee osteoarthritis (OA) and to exam its correlation with radiographic and symptomatic severity of the disease.

Material/methods: A total of 37 knee OA patients and 20 healthy controls were enrolled in this study. Knee OA radiographic grading was performed according to the Kellgren-Lawrence (KL) grading system by evaluating X-ray changes observed in anteroposterior knee radiography. Symptomatic severity of the disease was evaluated according to the Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores. BMP-2 levels in serum and SF were determined using enzyme-linked immunosorbent assay.

Results: Serum BMP-2 level in patients with knee OA was higher than that in healthy controls. Knee OA patients with KL grade 4 showed significantly elevated BMP-2 levels in the serum and SF compared with those with KL grade 2 and 3. Knee OA patients with KL grade 3 had significant higher SF levels of BMP-2 than those with KL grade 2. BMP-2 levels in the serum and SF of knee OA patients were both positively correlated with KL grades and WOMAC scores.

Conclusions: BMP2 levels in serum and SF were closely related to the radiographic and symptomatic severity of knee OA and may serve as an alternative biochemical parameter to determine disease severity of primary knee OA.

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Related in: MedlinePlus

Correlation between serum BMP-2 levels of knee OA patients and disease severity classified according to KL grading system (r=0.81, P<0.001). BMP-2: morphogenetic protein 2; OA: osteoarthritis.
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f1-medscimonit-21-363: Correlation between serum BMP-2 levels of knee OA patients and disease severity classified according to KL grading system (r=0.81, P<0.001). BMP-2: morphogenetic protein 2; OA: osteoarthritis.

Mentions: The association of BMP-2 levels in serum and SF with radiographic severity is illustrated in Figure 1 and Figure 2. Spearman’s rank correlation analysis showed that BMP-2 levels in serum and SF were both positively correlated with radiographic severity of knee OA (r=0.81, P<0.001 and r=0.78, P<0.001, respectively). We also analyzed the association of BMP-2 levels in serum and SF; the results showed that serum BMP-2 levels had a positive correlation with SF BMP-2 levels (r=0.65, P<0.001) (Figure 3). Multinomial logistic regression analysis showed that BMP-2 levels in serum and SF were both positively correlated with KL grades after adjusting for other variables such as age, sex, and BMI (chi-square=11.56, P=0.003 and chi-square=12.32, P=0.002, respectively).


Correlation of bone morphogenetic protein-2 levels in serum and synovial fluid with disease severity of knee osteoarthritis.

Liu Y, Hou R, Yin R, Yin W - Med. Sci. Monit. (2015)

Correlation between serum BMP-2 levels of knee OA patients and disease severity classified according to KL grading system (r=0.81, P<0.001). BMP-2: morphogenetic protein 2; OA: osteoarthritis.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4321411&req=5

f1-medscimonit-21-363: Correlation between serum BMP-2 levels of knee OA patients and disease severity classified according to KL grading system (r=0.81, P<0.001). BMP-2: morphogenetic protein 2; OA: osteoarthritis.
Mentions: The association of BMP-2 levels in serum and SF with radiographic severity is illustrated in Figure 1 and Figure 2. Spearman’s rank correlation analysis showed that BMP-2 levels in serum and SF were both positively correlated with radiographic severity of knee OA (r=0.81, P<0.001 and r=0.78, P<0.001, respectively). We also analyzed the association of BMP-2 levels in serum and SF; the results showed that serum BMP-2 levels had a positive correlation with SF BMP-2 levels (r=0.65, P<0.001) (Figure 3). Multinomial logistic regression analysis showed that BMP-2 levels in serum and SF were both positively correlated with KL grades after adjusting for other variables such as age, sex, and BMI (chi-square=11.56, P=0.003 and chi-square=12.32, P=0.002, respectively).

Bottom Line: This study aimed to investigate the bone morphogenetic protein-2 (BMP-2) levels in serum and synovial fluid (SF) of patients with primary knee osteoarthritis (OA) and to exam its correlation with radiographic and symptomatic severity of the disease.Symptomatic severity of the disease was evaluated according to the Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores.BMP-2 levels in serum and SF were determined using enzyme-linked immunosorbent assay.

View Article: PubMed Central - PubMed

Affiliation: Department of Ultrasonography, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China (mainland).

ABSTRACT

Background: This study aimed to investigate the bone morphogenetic protein-2 (BMP-2) levels in serum and synovial fluid (SF) of patients with primary knee osteoarthritis (OA) and to exam its correlation with radiographic and symptomatic severity of the disease.

Material/methods: A total of 37 knee OA patients and 20 healthy controls were enrolled in this study. Knee OA radiographic grading was performed according to the Kellgren-Lawrence (KL) grading system by evaluating X-ray changes observed in anteroposterior knee radiography. Symptomatic severity of the disease was evaluated according to the Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores. BMP-2 levels in serum and SF were determined using enzyme-linked immunosorbent assay.

Results: Serum BMP-2 level in patients with knee OA was higher than that in healthy controls. Knee OA patients with KL grade 4 showed significantly elevated BMP-2 levels in the serum and SF compared with those with KL grade 2 and 3. Knee OA patients with KL grade 3 had significant higher SF levels of BMP-2 than those with KL grade 2. BMP-2 levels in the serum and SF of knee OA patients were both positively correlated with KL grades and WOMAC scores.

Conclusions: BMP2 levels in serum and SF were closely related to the radiographic and symptomatic severity of knee OA and may serve as an alternative biochemical parameter to determine disease severity of primary knee OA.

Show MeSH
Related in: MedlinePlus