Haemonchotolerance in West African Dwarf goats: contribution to sustainable, anthelmintics-free helminth control in traditionally managed Nigerian dwarf goats.
Bottom Line: Here, we summarise the history of this breed and explain its economic importance in rural West Africa.If haemonchotolerance can be shown to be genetically controlled, it should be possible to exploit the underlying genes to improve GIN resistance among productive fibre and milk producing breeds of goats, most of which are highly susceptible to nematode infections.Either introgression of resistance alleles into susceptible breeds by conventional breeding, or transgenesis could be used to develop novel parasite-resistant, but highly productive breeds, or to improve the resistance of existing breeds, benefitting the local West African rural economy as well as global caprine livestock agriculture.
Affiliation: Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.Show MeSH
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Mentions: A similar picture emerged from our studies of naturally acquired infections in both humid  and savannah  zones of the country with respect to (i) extremely low infection intensities/worm burdens (Wb), which were dominated by H. contortus; (ii) the preponderance of this strong haemonchotolerant phenotype in the goat population; and (iii) the high variability in worm burdens. Approximately 80% of the WAD goat population had Wb < 100, even during the peak of the rainy season when environmental conditions are most favourable for the transmission of infection in the area . In one of our field studies , less than 5% of the goat population (equivalent to Class 3 phenotype in Fig. 3), the Haemonchus susceptible phenotype, had Wb > 1000. An individual goat in this category had a very heavy Wb of 9610, which consisted of mostly H. contortus and Trichostrongylus colubriformis.Figure 3.
Affiliation: Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.