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Haemonchotolerance in West African Dwarf goats: contribution to sustainable, anthelmintics-free helminth control in traditionally managed Nigerian dwarf goats.

Chiejina SN, Behnke JM, Fakae BB - Parasite (2015)

Bottom Line: Here, we summarise the history of this breed and explain its economic importance in rural West Africa.If haemonchotolerance can be shown to be genetically controlled, it should be possible to exploit the underlying genes to improve GIN resistance among productive fibre and milk producing breeds of goats, most of which are highly susceptible to nematode infections.Either introgression of resistance alleles into susceptible breeds by conventional breeding, or transgenesis could be used to develop novel parasite-resistant, but highly productive breeds, or to improve the resistance of existing breeds, benefitting the local West African rural economy as well as global caprine livestock agriculture.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.

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Distribution of FEC phenotypes in naturally acquired infections. Overall percentage of high, intermediate and low infection levels with GI nematodes in savannah WAD goats, based on faecal egg counts (FECs), as reflected in the percentage of goats at two markets (Akpagher and Gboko), classified in FEC class 0 (no eggs detected), FEC class 1 (1–50 Epg), FEC class 2 (51–1500 Epg) and FEC class 3 (>1500 Epg). Akpagher is shown in stippled columns and Gboko in open columns. The predominance of low FEC (strong responder) phenotypes is apparent. For further details see Behnke et al. [6].
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Figure 3: Distribution of FEC phenotypes in naturally acquired infections. Overall percentage of high, intermediate and low infection levels with GI nematodes in savannah WAD goats, based on faecal egg counts (FECs), as reflected in the percentage of goats at two markets (Akpagher and Gboko), classified in FEC class 0 (no eggs detected), FEC class 1 (1–50 Epg), FEC class 2 (51–1500 Epg) and FEC class 3 (>1500 Epg). Akpagher is shown in stippled columns and Gboko in open columns. The predominance of low FEC (strong responder) phenotypes is apparent. For further details see Behnke et al. [6].

Mentions: A similar picture emerged from our studies of naturally acquired infections in both humid [7] and savannah [6] zones of the country with respect to (i) extremely low infection intensities/worm burdens (Wb), which were dominated by H. contortus; (ii) the preponderance of this strong haemonchotolerant phenotype in the goat population; and (iii) the high variability in worm burdens. Approximately 80% of the WAD goat population had Wb < 100, even during the peak of the rainy season when environmental conditions are most favourable for the transmission of infection in the area [22]. In one of our field studies [6], less than 5% of the goat population (equivalent to Class 3 phenotype in Fig. 3), the Haemonchus susceptible phenotype, had Wb > 1000. An individual goat in this category had a very heavy Wb of 9610, which consisted of mostly H. contortus and Trichostrongylus colubriformis.Figure 3.


Haemonchotolerance in West African Dwarf goats: contribution to sustainable, anthelmintics-free helminth control in traditionally managed Nigerian dwarf goats.

Chiejina SN, Behnke JM, Fakae BB - Parasite (2015)

Distribution of FEC phenotypes in naturally acquired infections. Overall percentage of high, intermediate and low infection levels with GI nematodes in savannah WAD goats, based on faecal egg counts (FECs), as reflected in the percentage of goats at two markets (Akpagher and Gboko), classified in FEC class 0 (no eggs detected), FEC class 1 (1–50 Epg), FEC class 2 (51–1500 Epg) and FEC class 3 (>1500 Epg). Akpagher is shown in stippled columns and Gboko in open columns. The predominance of low FEC (strong responder) phenotypes is apparent. For further details see Behnke et al. [6].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4321401&req=5

Figure 3: Distribution of FEC phenotypes in naturally acquired infections. Overall percentage of high, intermediate and low infection levels with GI nematodes in savannah WAD goats, based on faecal egg counts (FECs), as reflected in the percentage of goats at two markets (Akpagher and Gboko), classified in FEC class 0 (no eggs detected), FEC class 1 (1–50 Epg), FEC class 2 (51–1500 Epg) and FEC class 3 (>1500 Epg). Akpagher is shown in stippled columns and Gboko in open columns. The predominance of low FEC (strong responder) phenotypes is apparent. For further details see Behnke et al. [6].
Mentions: A similar picture emerged from our studies of naturally acquired infections in both humid [7] and savannah [6] zones of the country with respect to (i) extremely low infection intensities/worm burdens (Wb), which were dominated by H. contortus; (ii) the preponderance of this strong haemonchotolerant phenotype in the goat population; and (iii) the high variability in worm burdens. Approximately 80% of the WAD goat population had Wb < 100, even during the peak of the rainy season when environmental conditions are most favourable for the transmission of infection in the area [22]. In one of our field studies [6], less than 5% of the goat population (equivalent to Class 3 phenotype in Fig. 3), the Haemonchus susceptible phenotype, had Wb > 1000. An individual goat in this category had a very heavy Wb of 9610, which consisted of mostly H. contortus and Trichostrongylus colubriformis.Figure 3.

Bottom Line: Here, we summarise the history of this breed and explain its economic importance in rural West Africa.If haemonchotolerance can be shown to be genetically controlled, it should be possible to exploit the underlying genes to improve GIN resistance among productive fibre and milk producing breeds of goats, most of which are highly susceptible to nematode infections.Either introgression of resistance alleles into susceptible breeds by conventional breeding, or transgenesis could be used to develop novel parasite-resistant, but highly productive breeds, or to improve the resistance of existing breeds, benefitting the local West African rural economy as well as global caprine livestock agriculture.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.

Show MeSH
Related in: MedlinePlus