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The neurophysiology of biological motion perception in schizophrenia.

Jahshan C, Wynn JK, Mathis KI, Green MF - Brain Behav (2014)

Bottom Line: At the neural level, P1 was reduced in the schizophrenia group but did not differ among conditions in either group.There were no group differences in N1 but both groups had the largest N1 in the 70% condition.The EEG results showed that biological motion did not influence the earliest stage of visual processing (P1).

View Article: PubMed Central - PubMed

Affiliation: Mental Illness Research, Education and Clinical Center (MIRECC), VA Greater Los Angeles Healthcare System Los Angeles, California ; Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, California.

ABSTRACT

Introduction: The ability to recognize human biological motion is a fundamental aspect of social cognition that is impaired in people with schizophrenia. However, little is known about the neural substrates of impaired biological motion perception in schizophrenia. In the current study, we assessed event-related potentials (ERPs) to human and nonhuman movement in schizophrenia.

Methods: Twenty-four subjects with schizophrenia and 18 healthy controls completed a biological motion task while their electroencephalography (EEG) was simultaneously recorded. Subjects watched clips of point-light animations containing 100%, 85%, or 70% biological motion, and were asked to decide whether the clip resembled human or nonhuman movement. Three ERPs were examined: P1, N1, and the late positive potential (LPP).

Results: Behaviorally, schizophrenia subjects identified significantly fewer stimuli as human movement compared to healthy controls in the 100% and 85% conditions. At the neural level, P1 was reduced in the schizophrenia group but did not differ among conditions in either group. There were no group differences in N1 but both groups had the largest N1 in the 70% condition. There was a condition × group interaction for the LPP: Healthy controls had a larger LPP to 100% versus 85% and 70% biological motion; there was no difference among conditions in schizophrenia subjects.

Conclusions: Consistent with previous findings, schizophrenia subjects were impaired in their ability to recognize biological motion. The EEG results showed that biological motion did not influence the earliest stage of visual processing (P1). Although schizophrenia subjects showed the same pattern of N1 results relative to healthy controls, they were impaired at a later stage (LPP), reflecting a dysfunction in the identification of human form in biological versus nonbiological motion stimuli.

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Related in: MedlinePlus

Grand average P1/N1 event-related potentials in response to 100% (black line), 85% (red line), and 70% (blue line) biological motion for controls (upper panel) and schizophrenia individuals (lower panel). The waveforms are shown at pooled electrodes P6, P8, PO8, and O2 over the right hemisphere and P5, P7, PO7, and O1 over the left hemisphere.
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fig05: Grand average P1/N1 event-related potentials in response to 100% (black line), 85% (red line), and 70% (blue line) biological motion for controls (upper panel) and schizophrenia individuals (lower panel). The waveforms are shown at pooled electrodes P6, P8, PO8, and O2 over the right hemisphere and P5, P7, PO7, and O1 over the left hemisphere.

Mentions: For the N1, there was a significant main effect of condition, F(2, 80) = 7.88, P = 0.001, ε = 0.96, main effect of hemisphere, F(1, 80) = 4.97, P = 0.03, and condition × hemisphere interaction, F(2, 80) = 26.11, P < 0.001, ε = 0.86. The main effect of group was not significant. N1 was significantly larger in the 70% condition (−2.82 (3.45) μV) compared to the 100% (−2.09 (3.08) μV, P < 0.05) and 85% conditions (−1.84 (2.90) μV, P < 0.001). N1 was significantly larger in the left compared to the right hemisphere, −2.64 (3.58) μV versus −1.86 (2.78) μV, respectively. The interaction was due to N1 being significantly larger in the left compared to the right hemisphere for the 100% (P = 0.001) and 85% (P = 0.005) conditions only. Figure5 shows grand average P1/N1 waveforms for each group and condition.


The neurophysiology of biological motion perception in schizophrenia.

Jahshan C, Wynn JK, Mathis KI, Green MF - Brain Behav (2014)

Grand average P1/N1 event-related potentials in response to 100% (black line), 85% (red line), and 70% (blue line) biological motion for controls (upper panel) and schizophrenia individuals (lower panel). The waveforms are shown at pooled electrodes P6, P8, PO8, and O2 over the right hemisphere and P5, P7, PO7, and O1 over the left hemisphere.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4321396&req=5

fig05: Grand average P1/N1 event-related potentials in response to 100% (black line), 85% (red line), and 70% (blue line) biological motion for controls (upper panel) and schizophrenia individuals (lower panel). The waveforms are shown at pooled electrodes P6, P8, PO8, and O2 over the right hemisphere and P5, P7, PO7, and O1 over the left hemisphere.
Mentions: For the N1, there was a significant main effect of condition, F(2, 80) = 7.88, P = 0.001, ε = 0.96, main effect of hemisphere, F(1, 80) = 4.97, P = 0.03, and condition × hemisphere interaction, F(2, 80) = 26.11, P < 0.001, ε = 0.86. The main effect of group was not significant. N1 was significantly larger in the 70% condition (−2.82 (3.45) μV) compared to the 100% (−2.09 (3.08) μV, P < 0.05) and 85% conditions (−1.84 (2.90) μV, P < 0.001). N1 was significantly larger in the left compared to the right hemisphere, −2.64 (3.58) μV versus −1.86 (2.78) μV, respectively. The interaction was due to N1 being significantly larger in the left compared to the right hemisphere for the 100% (P = 0.001) and 85% (P = 0.005) conditions only. Figure5 shows grand average P1/N1 waveforms for each group and condition.

Bottom Line: At the neural level, P1 was reduced in the schizophrenia group but did not differ among conditions in either group.There were no group differences in N1 but both groups had the largest N1 in the 70% condition.The EEG results showed that biological motion did not influence the earliest stage of visual processing (P1).

View Article: PubMed Central - PubMed

Affiliation: Mental Illness Research, Education and Clinical Center (MIRECC), VA Greater Los Angeles Healthcare System Los Angeles, California ; Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, California.

ABSTRACT

Introduction: The ability to recognize human biological motion is a fundamental aspect of social cognition that is impaired in people with schizophrenia. However, little is known about the neural substrates of impaired biological motion perception in schizophrenia. In the current study, we assessed event-related potentials (ERPs) to human and nonhuman movement in schizophrenia.

Methods: Twenty-four subjects with schizophrenia and 18 healthy controls completed a biological motion task while their electroencephalography (EEG) was simultaneously recorded. Subjects watched clips of point-light animations containing 100%, 85%, or 70% biological motion, and were asked to decide whether the clip resembled human or nonhuman movement. Three ERPs were examined: P1, N1, and the late positive potential (LPP).

Results: Behaviorally, schizophrenia subjects identified significantly fewer stimuli as human movement compared to healthy controls in the 100% and 85% conditions. At the neural level, P1 was reduced in the schizophrenia group but did not differ among conditions in either group. There were no group differences in N1 but both groups had the largest N1 in the 70% condition. There was a condition × group interaction for the LPP: Healthy controls had a larger LPP to 100% versus 85% and 70% biological motion; there was no difference among conditions in schizophrenia subjects.

Conclusions: Consistent with previous findings, schizophrenia subjects were impaired in their ability to recognize biological motion. The EEG results showed that biological motion did not influence the earliest stage of visual processing (P1). Although schizophrenia subjects showed the same pattern of N1 results relative to healthy controls, they were impaired at a later stage (LPP), reflecting a dysfunction in the identification of human form in biological versus nonbiological motion stimuli.

Show MeSH
Related in: MedlinePlus