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Role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism.

Zhong ZX, Li B, Li CR, Zhang QF, Liu ZD, Zhang PF, Gu XF, Luo H, Li MJ, Luo HS, Ye GH, Wen FL - Braz. J. Med. Biol. Res. (2014)

Bottom Line: Compared with the SAP group, the plaque burden and vascular remodeling index in the UAP group were significantly greater than in the SAP group (P<0.01).Chemotactic activity and the number of mobile monocytes in the UAP group were significantly greater than in the SAP group (P<0.01).Concentrations of hs-CRP, MCP-1, RANTES, and fractalkine in the serum of the UAP group were significantly higher than in the serum of the SAP group (P<0.05 or P<0.01), and expression of MCP-1, RANTES, and fractalkine mRNA was significantly higher than in the SAP group (P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, Meizhou, Guangdong, China.

ABSTRACT
Our aim was to investigate the role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism. Coronary angiography and intravascular ultrasound (IVUS) were performed in 60 stable angina pectoris (SAP) patients and 60 unstable angina pectoris (UAP) patients. The chemotactic activity of monocytes in the 2 groups of patients was examined in Transwell chambers. High-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1), regulated on activation in normal T-cell expressed and secreted (RANTES), and fractalkine in serum were examined with ELISA kits, and expression of MCP-1, RANTES, and fractalkine mRNA was examined with real-time PCR. In the SAP group, 92 plaques were detected with IVUS. In the UAP group, 96 plaques were detected with IVUS. The plaques in the UAP group were mainly lipid 51.04% (49/96) and the plaques in the SAP group were mainly fibrous 52.17% (48/92). Compared with the SAP group, the plaque burden and vascular remodeling index in the UAP group were significantly greater than in the SAP group (P<0.01). Chemotactic activity and the number of mobile monocytes in the UAP group were significantly greater than in the SAP group (P<0.01). Concentrations of hs-CRP, MCP-1, RANTES, and fractalkine in the serum of the UAP group were significantly higher than in the serum of the SAP group (P<0.05 or P<0.01), and expression of MCP-1, RANTES, and fractalkine mRNA was significantly higher than in the SAP group (P<0.05). MCP-1, RANTES, and fractalkine probably promote instability of coronary atherosclerotic plaque.

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Related in: MedlinePlus

Intravascular ultrasound imaging of the stable (SAP) and unstable (UAP)angina pectoris groups. A, SAP group.Eccentrically-distributed fibrous plaques appeared with enhanced echo.B, UAP group. Eccentrically-distributed lipid plaquesappeared with low echo.
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f01: Intravascular ultrasound imaging of the stable (SAP) and unstable (UAP)angina pectoris groups. A, SAP group.Eccentrically-distributed fibrous plaques appeared with enhanced echo.B, UAP group. Eccentrically-distributed lipid plaquesappeared with low echo.

Mentions: In the SAP group, 92 plaques were detected. In the UAP group, 90 plaques weredetected. The lesions of the SAP patients were mainly fibrous plaques (52.17%) whilethose of the UAP group were mainly lipid plaques (51.04%). Comparison between the twogroups was statistically different (Figure 1,Table 1). Comparison of EEMA, PA, EI, andPB between the two groups was statistically different (P<0.05 or P<0.01), butthe comparison of LA was not statistically different. Comparison of RI between thetwo groups was statistically different. The SAP group appeared as negative remodelingwhile the UAP group appeared as positive remodeling (Table 2). The ratio of ruptured plaques in the UAP group was about 70.83%,which was statistically different when compared with the SAP group (P<0.01; Table 1).


Role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism.

Zhong ZX, Li B, Li CR, Zhang QF, Liu ZD, Zhang PF, Gu XF, Luo H, Li MJ, Luo HS, Ye GH, Wen FL - Braz. J. Med. Biol. Res. (2014)

Intravascular ultrasound imaging of the stable (SAP) and unstable (UAP)angina pectoris groups. A, SAP group.Eccentrically-distributed fibrous plaques appeared with enhanced echo.B, UAP group. Eccentrically-distributed lipid plaquesappeared with low echo.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4321222&req=5

f01: Intravascular ultrasound imaging of the stable (SAP) and unstable (UAP)angina pectoris groups. A, SAP group.Eccentrically-distributed fibrous plaques appeared with enhanced echo.B, UAP group. Eccentrically-distributed lipid plaquesappeared with low echo.
Mentions: In the SAP group, 92 plaques were detected. In the UAP group, 90 plaques weredetected. The lesions of the SAP patients were mainly fibrous plaques (52.17%) whilethose of the UAP group were mainly lipid plaques (51.04%). Comparison between the twogroups was statistically different (Figure 1,Table 1). Comparison of EEMA, PA, EI, andPB between the two groups was statistically different (P<0.05 or P<0.01), butthe comparison of LA was not statistically different. Comparison of RI between thetwo groups was statistically different. The SAP group appeared as negative remodelingwhile the UAP group appeared as positive remodeling (Table 2). The ratio of ruptured plaques in the UAP group was about 70.83%,which was statistically different when compared with the SAP group (P<0.01; Table 1).

Bottom Line: Compared with the SAP group, the plaque burden and vascular remodeling index in the UAP group were significantly greater than in the SAP group (P<0.01).Chemotactic activity and the number of mobile monocytes in the UAP group were significantly greater than in the SAP group (P<0.01).Concentrations of hs-CRP, MCP-1, RANTES, and fractalkine in the serum of the UAP group were significantly higher than in the serum of the SAP group (P<0.05 or P<0.01), and expression of MCP-1, RANTES, and fractalkine mRNA was significantly higher than in the SAP group (P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Meizhou Hospital Affiliated to Zhongshan University, Meizhou, Guangdong, China.

ABSTRACT
Our aim was to investigate the role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism. Coronary angiography and intravascular ultrasound (IVUS) were performed in 60 stable angina pectoris (SAP) patients and 60 unstable angina pectoris (UAP) patients. The chemotactic activity of monocytes in the 2 groups of patients was examined in Transwell chambers. High-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1), regulated on activation in normal T-cell expressed and secreted (RANTES), and fractalkine in serum were examined with ELISA kits, and expression of MCP-1, RANTES, and fractalkine mRNA was examined with real-time PCR. In the SAP group, 92 plaques were detected with IVUS. In the UAP group, 96 plaques were detected with IVUS. The plaques in the UAP group were mainly lipid 51.04% (49/96) and the plaques in the SAP group were mainly fibrous 52.17% (48/92). Compared with the SAP group, the plaque burden and vascular remodeling index in the UAP group were significantly greater than in the SAP group (P<0.01). Chemotactic activity and the number of mobile monocytes in the UAP group were significantly greater than in the SAP group (P<0.01). Concentrations of hs-CRP, MCP-1, RANTES, and fractalkine in the serum of the UAP group were significantly higher than in the serum of the SAP group (P<0.05 or P<0.01), and expression of MCP-1, RANTES, and fractalkine mRNA was significantly higher than in the SAP group (P<0.05). MCP-1, RANTES, and fractalkine probably promote instability of coronary atherosclerotic plaque.

Show MeSH
Related in: MedlinePlus