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Zinc, aging, and immunosenescence: an overview.

Cabrera ÁJ - Pathobiol Aging Age Relat Dis (2015)

Bottom Line: Zinc plays an essential role in many biochemical pathways and participates in several cell functions, including the immune response.This review describes the role of zinc in human health, aging, and immunosenescence.The possible benefits of zinc supplementation to enhance immune function are discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine and Geriatrics, Academic Hospital "Dr. Gustavo Aldereguía Lima", Cienfuegos, Cuba; jromero@gal.sld.cu.

ABSTRACT
Zinc plays an essential role in many biochemical pathways and participates in several cell functions, including the immune response. This review describes the role of zinc in human health, aging, and immunosenescence. Zinc deficiency is frequent in the elderly and leads to changes similar to those that occur in oxidative inflammatory aging (oxi-inflamm-aging) and immunosenescence. The possible benefits of zinc supplementation to enhance immune function are discussed.

No MeSH data available.


Related in: MedlinePlus

Zinc, through the activation of protein A-20 inhibits (discontinuous arrow) the IkB kinase (IKK) causing inhibition of the inflammatory cascade. In zinc deficiency, the protein A-20 is ‘free’, and the activation of NF-κB and the generation of inflammatory cytokines are induced.
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Figure 0002: Zinc, through the activation of protein A-20 inhibits (discontinuous arrow) the IkB kinase (IKK) causing inhibition of the inflammatory cascade. In zinc deficiency, the protein A-20 is ‘free’, and the activation of NF-κB and the generation of inflammatory cytokines are induced.

Mentions: A system of signals has been described in monocytes where a complex interaction occurs among Zn, nitric oxide, cyclic nucleotide signaling, and the IL-1 receptor associated with kinase-1. These act against the production of inflammatory cytokines (84). Also, the function of dendritic cells is affected by disorders in the homeostasis of Zn implicating the transporting proteins (ZIP) during the upregulation induced by lipopolysaccharides and stimulating molecules (85). A study on the effect of Zn ions in the promonocytic leukemia HL-CZ cell line showed that treatment with Zn caused the release of chemokine and inflammatory cytokines through activation of multiple transcription factors related to the immune response (86). Figure 2 illustrates the role of Zn as a signal molecule in the immune system.


Zinc, aging, and immunosenescence: an overview.

Cabrera ÁJ - Pathobiol Aging Age Relat Dis (2015)

Zinc, through the activation of protein A-20 inhibits (discontinuous arrow) the IkB kinase (IKK) causing inhibition of the inflammatory cascade. In zinc deficiency, the protein A-20 is ‘free’, and the activation of NF-κB and the generation of inflammatory cytokines are induced.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4321209&req=5

Figure 0002: Zinc, through the activation of protein A-20 inhibits (discontinuous arrow) the IkB kinase (IKK) causing inhibition of the inflammatory cascade. In zinc deficiency, the protein A-20 is ‘free’, and the activation of NF-κB and the generation of inflammatory cytokines are induced.
Mentions: A system of signals has been described in monocytes where a complex interaction occurs among Zn, nitric oxide, cyclic nucleotide signaling, and the IL-1 receptor associated with kinase-1. These act against the production of inflammatory cytokines (84). Also, the function of dendritic cells is affected by disorders in the homeostasis of Zn implicating the transporting proteins (ZIP) during the upregulation induced by lipopolysaccharides and stimulating molecules (85). A study on the effect of Zn ions in the promonocytic leukemia HL-CZ cell line showed that treatment with Zn caused the release of chemokine and inflammatory cytokines through activation of multiple transcription factors related to the immune response (86). Figure 2 illustrates the role of Zn as a signal molecule in the immune system.

Bottom Line: Zinc plays an essential role in many biochemical pathways and participates in several cell functions, including the immune response.This review describes the role of zinc in human health, aging, and immunosenescence.The possible benefits of zinc supplementation to enhance immune function are discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine and Geriatrics, Academic Hospital "Dr. Gustavo Aldereguía Lima", Cienfuegos, Cuba; jromero@gal.sld.cu.

ABSTRACT
Zinc plays an essential role in many biochemical pathways and participates in several cell functions, including the immune response. This review describes the role of zinc in human health, aging, and immunosenescence. Zinc deficiency is frequent in the elderly and leads to changes similar to those that occur in oxidative inflammatory aging (oxi-inflamm-aging) and immunosenescence. The possible benefits of zinc supplementation to enhance immune function are discussed.

No MeSH data available.


Related in: MedlinePlus