Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of split vs single dose.
Bottom Line: Ingestion of 1 and 2 L PEG electrolyte solution caused a rapid increase in the small bowel and colonic volumes and a robust rise in colonic motility.The increase in both volumes and motility was dose dependent.Such a challenge, being well-tolerated, could be a useful way of assessing colonic motility in future studies.
Affiliation: Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals, University of Nottingham, Nottingham, UK.Show MeSH
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Mentions: The baseline ascending colon motility index (Fig.5) was close to zero for most subjects. Both dosing regimens induced marked increases in ascending colon motility in all subjects. After treatment, the motility index was twofold higher for the single 2 L dose compared with the 1 L split dose group (p = 0.0103). The scores were numerically higher for the single dose throughout the study day though the difference in AUC4h was not statistically significant (Table S3). The peak change from baseline values in ascending colonic motility index correlated positively and significantly with change from baseline values in ascending colon volume, Spearman's r = 0.53, p = 0.0128 (Fig.6). Removing the outlier at 800 mL change in ascending colon volume from baseline does not change the Spearman's correlation r = 0.53, p = 0.0161. Two ascending colon motility MRI movies are shown in Supporting Information (Movie S1 and S2).
Affiliation: Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals, University of Nottingham, Nottingham, UK.