Altered DNA methylation status of human brain derived neurotrophis factor gene could be useful as biomarker of depression.
Bottom Line: The average DNA methylation rate was significantly decreased in the highest K6 score group compared to the lowest group (methylated signals, 14.2% vs. 16.5%, P = 2 · 16 × 10(-198)).Regarding the job-strain score, there was a slight increase in the methylation level of the whole gene in the group with the highest score compared to that with the lowest score; however, these groups showed no difference in the promoter region.Our results revealed significant changes in the DNA methylation status of the complete human BDNF gene in persons with depression compared to normal individuals, especially in the promoter region of exon 1.
Affiliation: Department of Clinical Research and Informatics, National Center for Global Health and Medicine, Tokyo, Japan.Show MeSH
Related in: MedlinePlus
Mentions: As shown in Figure 2, the average methylation level of the 97 loci included in the Q4 group was 14.2%, which was significantly lower than that observed in the Q1 group (16.5%, P = 2.16 × 10−198, chi-squared test) (Fig. 2). On the CpG island located in exon 1, the average methylation level for CpGs No. 85–94 of the Q4 group was only half of that for these CpGs of the Q1 group (5.8% and 10.4%, respectively); the difference between the two groups was significant (P = 3.67 × 10−133, chi-squared test).
Affiliation: Department of Clinical Research and Informatics, National Center for Global Health and Medicine, Tokyo, Japan.