Limits...
Metaplastic breast carcinoma; melanocytic variant, a very rare tumour.

Nzegwu MA, Sule E, Uzoigwe J, Achi F - J Surg Case Rep (2015)

Bottom Line: No palpable axillary nodes were seen.Chest X-ray and abdominal ultrasound scan showed no involvement.Breast biopsy revealed an invasive metaplastic ductal carcinoma with melanocytic differentiation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pathology Department, University of Nigeria Medical School, Enugu, Nigeria martin_nze@yahoo.com.

No MeSH data available.


Related in: MedlinePlus

Tyrosinase positivity in keeping with melanocytic differentiation.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4321043&req=5

RJU158F8: Tyrosinase positivity in keeping with melanocytic differentiation.

Mentions: A 57-year-old woman presented with 5/12 history of left breast lump which gradually increase in size and became painful. Menarche was at 13 years without oral contraception. She had four confinements, the first being 20 years. Each child was breastfed for 8 months. No family history of breast cancer. Clinical examination showed breast asymmetry. Left breast was oedematous, shiny with extensive peau d'orange. Patient applied herbal preparations with multiple superficial skin excoriations. Outer quadrant breast mass was 8 cm, hard, with attachment to skin and underlying structures. No palpable axillary lymph node was felt and axillary ultrasonography, though desirable, was not done. Liver was not enlarged. Chest X-ray and abdominal ultrasound scan showed no involvement. Initial breast biopsy revealed an infiltrating atypical spindled tumour with hyperchromatic nuclei, which was both S100 and tyrosinase-positive. Tumour fungated with a darkly pigmented surface despite two cycles of neoadjuvant doxorubicin-based chemotherapy. Left simple mastectomy (Fig. 1) and axillary sampling (Fig. 2) of the sentinel and another slightly enlarged node were done, revealed a triple-negative invasive ductal carcinoma (Figs 3–6), with melanocytic differentiation (Figs 7 and 8), positivity for S-100 and patchy positivity for tyrosinase, an enzyme involved in melanin formation from dihydroxyl phenyl alanine. Only the sentinel node was involved, with the other showing reactive changes. Core biopsy of the tumour had ductal elements and was triple-negative.Figure 1:


Metaplastic breast carcinoma; melanocytic variant, a very rare tumour.

Nzegwu MA, Sule E, Uzoigwe J, Achi F - J Surg Case Rep (2015)

Tyrosinase positivity in keeping with melanocytic differentiation.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4321043&req=5

RJU158F8: Tyrosinase positivity in keeping with melanocytic differentiation.
Mentions: A 57-year-old woman presented with 5/12 history of left breast lump which gradually increase in size and became painful. Menarche was at 13 years without oral contraception. She had four confinements, the first being 20 years. Each child was breastfed for 8 months. No family history of breast cancer. Clinical examination showed breast asymmetry. Left breast was oedematous, shiny with extensive peau d'orange. Patient applied herbal preparations with multiple superficial skin excoriations. Outer quadrant breast mass was 8 cm, hard, with attachment to skin and underlying structures. No palpable axillary lymph node was felt and axillary ultrasonography, though desirable, was not done. Liver was not enlarged. Chest X-ray and abdominal ultrasound scan showed no involvement. Initial breast biopsy revealed an infiltrating atypical spindled tumour with hyperchromatic nuclei, which was both S100 and tyrosinase-positive. Tumour fungated with a darkly pigmented surface despite two cycles of neoadjuvant doxorubicin-based chemotherapy. Left simple mastectomy (Fig. 1) and axillary sampling (Fig. 2) of the sentinel and another slightly enlarged node were done, revealed a triple-negative invasive ductal carcinoma (Figs 3–6), with melanocytic differentiation (Figs 7 and 8), positivity for S-100 and patchy positivity for tyrosinase, an enzyme involved in melanin formation from dihydroxyl phenyl alanine. Only the sentinel node was involved, with the other showing reactive changes. Core biopsy of the tumour had ductal elements and was triple-negative.Figure 1:

Bottom Line: No palpable axillary nodes were seen.Chest X-ray and abdominal ultrasound scan showed no involvement.Breast biopsy revealed an invasive metaplastic ductal carcinoma with melanocytic differentiation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pathology Department, University of Nigeria Medical School, Enugu, Nigeria martin_nze@yahoo.com.

No MeSH data available.


Related in: MedlinePlus