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A hybrid IMRT/VMAT technique for the treatment of nasopharyngeal cancer.

Zhao N, Yang R, Jiang Y, Tian S, Guo F, Wang J - Biomed Res Int (2015)

Bottom Line: It can reduce the dose delivered to the TMJ, mandible, temporal lobe, and unspecified tissue with fewer MUs compared with 9F-IMRT and dose delivered to parotids, brainstem, and spinal cord compared with 2ARC-VMAT technique.The mean delivery time of Hybrid plans was shorter than that of 9F-IMRT plans (408 s versus 812 s; P=0.00) and longer than that of 2ARC-VMAT plans (408 s versus 179 s; P=0.00).Hybrid IMRT/VMAT technique could be a viable radiotherapy technique with better plan quality.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.

ABSTRACT
Hybrid IMRT/VMAT technique which combined intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) was developed for the treatment of nasopharyngeal cancer (NPC). Two-full-arc VMAT (2ARC-VMAT), 9-field IMRT (9F-IMRT), and Hybrid IMRT/VMAT plans for NPC were compared in terms of the dosimetric quality, sparing of organs at risk (OARs), and delivery efficiency. The Hybrid IMRT/VMAT technique can improve the target dose homogeneity and conformity compared with 9F-IMRT and 2ARC-VMAT. It can reduce the dose delivered to the TMJ, mandible, temporal lobe, and unspecified tissue with fewer MUs compared with 9F-IMRT and dose delivered to parotids, brainstem, and spinal cord compared with 2ARC-VMAT technique. The mean delivery time of Hybrid plans was shorter than that of 9F-IMRT plans (408 s versus 812 s; P=0.00) and longer than that of 2ARC-VMAT plans (408 s versus 179 s; P=0.00). Hybrid IMRT/VMAT technique could be a viable radiotherapy technique with better plan quality.

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Related in: MedlinePlus

Dose distributions on axial, coronal, and sagittal views for one representative case: (a) 9F-IMRT, (b) 2ARC-VMAT, and (c) Hybrid IMRT/VMAT.
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Related In: Results  -  Collection


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fig1: Dose distributions on axial, coronal, and sagittal views for one representative case: (a) 9F-IMRT, (b) 2ARC-VMAT, and (c) Hybrid IMRT/VMAT.

Mentions: The mean volumes of the PTV70, PTV59.4, and PTV54 were 82.11 cm3 (27.84 cm3 to 196.64 cm3), 445.10 cm3 (209.40 cm3 to 777.80 cm3), and 264.01 cm3 (121.78 cm3 to 549.21 cm3), respectively. For all 10 cases, all the plans were clinically acceptable, with at least 98% PTV receiving 95% of the prescribed dose. The typical isodose distribution and DVH comparison were given from Figures 1, 2, 3, and 4.


A hybrid IMRT/VMAT technique for the treatment of nasopharyngeal cancer.

Zhao N, Yang R, Jiang Y, Tian S, Guo F, Wang J - Biomed Res Int (2015)

Dose distributions on axial, coronal, and sagittal views for one representative case: (a) 9F-IMRT, (b) 2ARC-VMAT, and (c) Hybrid IMRT/VMAT.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4320861&req=5

fig1: Dose distributions on axial, coronal, and sagittal views for one representative case: (a) 9F-IMRT, (b) 2ARC-VMAT, and (c) Hybrid IMRT/VMAT.
Mentions: The mean volumes of the PTV70, PTV59.4, and PTV54 were 82.11 cm3 (27.84 cm3 to 196.64 cm3), 445.10 cm3 (209.40 cm3 to 777.80 cm3), and 264.01 cm3 (121.78 cm3 to 549.21 cm3), respectively. For all 10 cases, all the plans were clinically acceptable, with at least 98% PTV receiving 95% of the prescribed dose. The typical isodose distribution and DVH comparison were given from Figures 1, 2, 3, and 4.

Bottom Line: It can reduce the dose delivered to the TMJ, mandible, temporal lobe, and unspecified tissue with fewer MUs compared with 9F-IMRT and dose delivered to parotids, brainstem, and spinal cord compared with 2ARC-VMAT technique.The mean delivery time of Hybrid plans was shorter than that of 9F-IMRT plans (408 s versus 812 s; P=0.00) and longer than that of 2ARC-VMAT plans (408 s versus 179 s; P=0.00).Hybrid IMRT/VMAT technique could be a viable radiotherapy technique with better plan quality.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.

ABSTRACT
Hybrid IMRT/VMAT technique which combined intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) was developed for the treatment of nasopharyngeal cancer (NPC). Two-full-arc VMAT (2ARC-VMAT), 9-field IMRT (9F-IMRT), and Hybrid IMRT/VMAT plans for NPC were compared in terms of the dosimetric quality, sparing of organs at risk (OARs), and delivery efficiency. The Hybrid IMRT/VMAT technique can improve the target dose homogeneity and conformity compared with 9F-IMRT and 2ARC-VMAT. It can reduce the dose delivered to the TMJ, mandible, temporal lobe, and unspecified tissue with fewer MUs compared with 9F-IMRT and dose delivered to parotids, brainstem, and spinal cord compared with 2ARC-VMAT technique. The mean delivery time of Hybrid plans was shorter than that of 9F-IMRT plans (408 s versus 812 s; P=0.00) and longer than that of 2ARC-VMAT plans (408 s versus 179 s; P=0.00). Hybrid IMRT/VMAT technique could be a viable radiotherapy technique with better plan quality.

Show MeSH
Related in: MedlinePlus