Limits...
Repetitive transcranial magnetic stimulation ameliorates anxiety-like behavior and impaired sensorimotor gating in a rat model of post-traumatic stress disorder.

Wang HN, Bai YH, Chen YC, Zhang RG, Wang HH, Zhang YH, Gan JL, Peng ZW, Tan QR - PLoS ONE (2015)

Bottom Line: To assess the benefit of rTMS in a rat model of PTSD.Interestingly, rTMS administered immediately after stress prevented those impairment.Stress-induced anxiety-like behavior, increased plasma level of cortisol and impaired PPI occur after stress and high-frequency rTMS has the potential to ameliorate this behavior, suggesting that high frequency rTMS should be further evaluated for its use as a method for preventing PTSD.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.

ABSTRACT

Background: Repetitive transcranial magnetic stimulation (rTMS) has been employed for decades as a non-pharmacologic treatment for post-traumatic stress disorder (PTSD). Although a link has been suggested between PTSD and impaired sensorimotor gating (SG), studies assessing the effects of rTMS against PTSD or PTSD with impaired SG are scarce.

Aim: To assess the benefit of rTMS in a rat model of PTSD.

Methods: Using a modified single prolonged stress (SPS&S) rat model of PTSD, behavioral parameters were acquired using open field test (OFT), elevated plus maze test (EPMT), and prepulse inhibition trial (PPI), with or without 7 days of high frequency (10Hz) rTMS treatment of SPS&S rats.

Results: Anxiety-like behavior, impaired SG and increased plasma level of cortisol were observed in SPS&S animals after stress for a prolonged time. Interestingly, rTMS administered immediately after stress prevented those impairment.

Conclusion: Stress-induced anxiety-like behavior, increased plasma level of cortisol and impaired PPI occur after stress and high-frequency rTMS has the potential to ameliorate this behavior, suggesting that high frequency rTMS should be further evaluated for its use as a method for preventing PTSD.

Show MeSH

Related in: MedlinePlus

Behavior of approach-avoidance conflict in a rat model of PTSD.Time spent in open arms (A), number of entries into open arms (B) and their relative to overall levels (%) values (C, D) tested in the elevated plus maze. Data are expressed as mean ± SEM (n = 12 per group). *P < 0.05 vs. control.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4320076&req=5

pone.0117189.g003: Behavior of approach-avoidance conflict in a rat model of PTSD.Time spent in open arms (A), number of entries into open arms (B) and their relative to overall levels (%) values (C, D) tested in the elevated plus maze. Data are expressed as mean ± SEM (n = 12 per group). *P < 0.05 vs. control.

Mentions: As shown in Fig. 3, significant differences were found among the four groups in time spent in open arms (F3, 44 = 3.204, P = 0.032), with 77.93 ± 13.44, 36.62 ± 13.42, 26.43 ± 9.59, and 46.33 ± 14.66 s obtained for controls, and rats evaluated at 1, 7, and 14 days after SPS&S, respectively. Similar results were obtained for percent time spent in open arms, with 25.98 ± 4.48, 12.21 ± 4.47, 8.81 ± 3.2, and 15.44 ± 4.89% (F3, 44 = 3.204, P = 0.032) and percent numbers of entry into the open arms, with 32.19 ± 4.63, 16.51 ± 5.23, 12.55 ± 5.46, and 16.38 ± 4.88% (F3, 44 = 2.968, P = 0.042) for control animals and rats evaluated at 1, 7, and 14 days after SPS&S, respectively. However no significant difference was obtained for absolute numbers of entry into the open arms (F3, 44 = 2.392, P = 0.081). These data indicated that rats submitted to SPS&S and evaluated 1 and 7 and 14 days showed a reduction in time spent in the open arms and percent time spent in the open arms compared to the control group (all P < 0.05), although the SPS&S 14 day group showed a slight increase compared with other SPS&S 7 animals. Each SPS&S group also showed a reduction in percent number of entries into the open arms (all P < 0.05).


Repetitive transcranial magnetic stimulation ameliorates anxiety-like behavior and impaired sensorimotor gating in a rat model of post-traumatic stress disorder.

Wang HN, Bai YH, Chen YC, Zhang RG, Wang HH, Zhang YH, Gan JL, Peng ZW, Tan QR - PLoS ONE (2015)

Behavior of approach-avoidance conflict in a rat model of PTSD.Time spent in open arms (A), number of entries into open arms (B) and their relative to overall levels (%) values (C, D) tested in the elevated plus maze. Data are expressed as mean ± SEM (n = 12 per group). *P < 0.05 vs. control.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4320076&req=5

pone.0117189.g003: Behavior of approach-avoidance conflict in a rat model of PTSD.Time spent in open arms (A), number of entries into open arms (B) and their relative to overall levels (%) values (C, D) tested in the elevated plus maze. Data are expressed as mean ± SEM (n = 12 per group). *P < 0.05 vs. control.
Mentions: As shown in Fig. 3, significant differences were found among the four groups in time spent in open arms (F3, 44 = 3.204, P = 0.032), with 77.93 ± 13.44, 36.62 ± 13.42, 26.43 ± 9.59, and 46.33 ± 14.66 s obtained for controls, and rats evaluated at 1, 7, and 14 days after SPS&S, respectively. Similar results were obtained for percent time spent in open arms, with 25.98 ± 4.48, 12.21 ± 4.47, 8.81 ± 3.2, and 15.44 ± 4.89% (F3, 44 = 3.204, P = 0.032) and percent numbers of entry into the open arms, with 32.19 ± 4.63, 16.51 ± 5.23, 12.55 ± 5.46, and 16.38 ± 4.88% (F3, 44 = 2.968, P = 0.042) for control animals and rats evaluated at 1, 7, and 14 days after SPS&S, respectively. However no significant difference was obtained for absolute numbers of entry into the open arms (F3, 44 = 2.392, P = 0.081). These data indicated that rats submitted to SPS&S and evaluated 1 and 7 and 14 days showed a reduction in time spent in the open arms and percent time spent in the open arms compared to the control group (all P < 0.05), although the SPS&S 14 day group showed a slight increase compared with other SPS&S 7 animals. Each SPS&S group also showed a reduction in percent number of entries into the open arms (all P < 0.05).

Bottom Line: To assess the benefit of rTMS in a rat model of PTSD.Interestingly, rTMS administered immediately after stress prevented those impairment.Stress-induced anxiety-like behavior, increased plasma level of cortisol and impaired PPI occur after stress and high-frequency rTMS has the potential to ameliorate this behavior, suggesting that high frequency rTMS should be further evaluated for its use as a method for preventing PTSD.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.

ABSTRACT

Background: Repetitive transcranial magnetic stimulation (rTMS) has been employed for decades as a non-pharmacologic treatment for post-traumatic stress disorder (PTSD). Although a link has been suggested between PTSD and impaired sensorimotor gating (SG), studies assessing the effects of rTMS against PTSD or PTSD with impaired SG are scarce.

Aim: To assess the benefit of rTMS in a rat model of PTSD.

Methods: Using a modified single prolonged stress (SPS&S) rat model of PTSD, behavioral parameters were acquired using open field test (OFT), elevated plus maze test (EPMT), and prepulse inhibition trial (PPI), with or without 7 days of high frequency (10Hz) rTMS treatment of SPS&S rats.

Results: Anxiety-like behavior, impaired SG and increased plasma level of cortisol were observed in SPS&S animals after stress for a prolonged time. Interestingly, rTMS administered immediately after stress prevented those impairment.

Conclusion: Stress-induced anxiety-like behavior, increased plasma level of cortisol and impaired PPI occur after stress and high-frequency rTMS has the potential to ameliorate this behavior, suggesting that high frequency rTMS should be further evaluated for its use as a method for preventing PTSD.

Show MeSH
Related in: MedlinePlus