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Low maternal vitamin D status during the second trimester of pregnancy: a cross-sectional study in Wuxi, China.

Xiao JP, Zang J, Pei JJ, Xu F, Zhu Y, Liao XP - PLoS ONE (2015)

Bottom Line: Serum 25-hydroxyvitamin D [25(OH)D] concentration was measured in samples from 5823 pregnant women in Wuxi City, China (latitude: 31.5o N), from January 2011 to June 2012.The median serum 25(OH)D concentration was 34.0 nmol/L [2.5 nmol/L 25(OH)D = 1 ng/mL 25(OH)D].Only 0.9% had a 25(OH)D level ≥ 80.0 nmol/L, which is the concentration recommended as adequate by the Endocrine Society (Washington, D.C., USA).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics, Wuxi Maternity and Child Health Hospital, Nanjing Medical University, Jiangsu, China; Perinatal Biology Center, Soochow University School of Medicine, Jiangsu, China.

ABSTRACT

Background: Vitamin D deficiency is common in pregnant women, but an optimal serum vitamin D level during pregnancy has not been determined and remains an area of active research. Vitamin D data from large populations of pregnant Chinese women are still limited.

Objective: To evaluate the vitamin D status of women in Eastern China during the second trimester of pregnancy.

Methods: A hospital-based, cross-sectional, observational study. Serum 25-hydroxyvitamin D [25(OH)D] concentration was measured in samples from 5823 pregnant women in Wuxi City, China (latitude: 31.5o N), from January 2011 to June 2012.

Results: The median serum 25(OH)D concentration was 34.0 nmol/L [2.5 nmol/L 25(OH)D = 1 ng/mL 25(OH)D]. Vitamin D deficiency [defined as 25(OH)D < 30 nmol/L according to the Institute of Medicine (National Academy of Sciences, Washington, D.C., USA)] or inadequacy [25(OH)D of 30-49.9 nmol/L] was identified in 40.7% and 38.0% of the women, respectively. Only 0.9% had a 25(OH)D level ≥ 80.0 nmol/L, which is the concentration recommended as adequate by the Endocrine Society (Washington, D.C., USA). Compared with older women, younger women were more likely to be deficient in vitamin D. There were significant differences in the 25(OH)D levels according to season. The 25(OH)D levels reached peak values in September and were correlated with (r = 0.337, P < 0.001), and fluctuated with, average monthly air temperatures.

Conclusions: There is a high prevalence of Vitamin D deficiency among pregnant Chinese women, and 25(OH)D levels varied according to season and air temperature. The results of this study also suggest that currently there is a big gap between the levels of Vitamin D detected in pregnant Chinese women and the levels recommended by the Endocrine Society.

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Proportions of different vitamin D categories in the study population.
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pone.0117748.g002: Proportions of different vitamin D categories in the study population.

Mentions: The median serum 25(OH)D concentration was 34.0 nmol/L (range, 10.1–108.7 nmol/L). Vitamin D deficiency and inadequacy were present in 40.7% and 38.0% of the women, respectively. Only 0.9% of the study population had 25(OH)D concentrations ≥ 80.0 nmol/L. During the winter season, most (57.3%) of the women were deficient in vitamin D, and only 6.8% of them had adequate vitamin D levels (Table 1 and Fig. 2).


Low maternal vitamin D status during the second trimester of pregnancy: a cross-sectional study in Wuxi, China.

Xiao JP, Zang J, Pei JJ, Xu F, Zhu Y, Liao XP - PLoS ONE (2015)

Proportions of different vitamin D categories in the study population.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4320063&req=5

pone.0117748.g002: Proportions of different vitamin D categories in the study population.
Mentions: The median serum 25(OH)D concentration was 34.0 nmol/L (range, 10.1–108.7 nmol/L). Vitamin D deficiency and inadequacy were present in 40.7% and 38.0% of the women, respectively. Only 0.9% of the study population had 25(OH)D concentrations ≥ 80.0 nmol/L. During the winter season, most (57.3%) of the women were deficient in vitamin D, and only 6.8% of them had adequate vitamin D levels (Table 1 and Fig. 2).

Bottom Line: Serum 25-hydroxyvitamin D [25(OH)D] concentration was measured in samples from 5823 pregnant women in Wuxi City, China (latitude: 31.5o N), from January 2011 to June 2012.The median serum 25(OH)D concentration was 34.0 nmol/L [2.5 nmol/L 25(OH)D = 1 ng/mL 25(OH)D].Only 0.9% had a 25(OH)D level ≥ 80.0 nmol/L, which is the concentration recommended as adequate by the Endocrine Society (Washington, D.C., USA).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics, Wuxi Maternity and Child Health Hospital, Nanjing Medical University, Jiangsu, China; Perinatal Biology Center, Soochow University School of Medicine, Jiangsu, China.

ABSTRACT

Background: Vitamin D deficiency is common in pregnant women, but an optimal serum vitamin D level during pregnancy has not been determined and remains an area of active research. Vitamin D data from large populations of pregnant Chinese women are still limited.

Objective: To evaluate the vitamin D status of women in Eastern China during the second trimester of pregnancy.

Methods: A hospital-based, cross-sectional, observational study. Serum 25-hydroxyvitamin D [25(OH)D] concentration was measured in samples from 5823 pregnant women in Wuxi City, China (latitude: 31.5o N), from January 2011 to June 2012.

Results: The median serum 25(OH)D concentration was 34.0 nmol/L [2.5 nmol/L 25(OH)D = 1 ng/mL 25(OH)D]. Vitamin D deficiency [defined as 25(OH)D < 30 nmol/L according to the Institute of Medicine (National Academy of Sciences, Washington, D.C., USA)] or inadequacy [25(OH)D of 30-49.9 nmol/L] was identified in 40.7% and 38.0% of the women, respectively. Only 0.9% had a 25(OH)D level ≥ 80.0 nmol/L, which is the concentration recommended as adequate by the Endocrine Society (Washington, D.C., USA). Compared with older women, younger women were more likely to be deficient in vitamin D. There were significant differences in the 25(OH)D levels according to season. The 25(OH)D levels reached peak values in September and were correlated with (r = 0.337, P < 0.001), and fluctuated with, average monthly air temperatures.

Conclusions: There is a high prevalence of Vitamin D deficiency among pregnant Chinese women, and 25(OH)D levels varied according to season and air temperature. The results of this study also suggest that currently there is a big gap between the levels of Vitamin D detected in pregnant Chinese women and the levels recommended by the Endocrine Society.

Show MeSH
Related in: MedlinePlus