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C-reactive protein and cardiovascular disease in East asians: a systematic review.

Saito I, Maruyama K, Eguchi E - Clin Med Insights Cardiol (2015)

Bottom Line: PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models.For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96-3.19, P = 0.07) and 1.76 (95% CI, 1.29-2.40, P < 0.001), respectively.Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.

View Article: PubMed Central - PubMed

Affiliation: Department of Basic Nursing and Health Science, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.

ABSTRACT
Elevated C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular disease (CVD) in Caucasians; however, evidence is lacking for East Asians, who have low CRP levels. PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models. The overall association between CRP levels and stroke was significant in six studies (risk ratio = 1.40 [95% confidence interval {CI}, 1.10-1.77], P = 0.008). The association with ischemic stroke was more evident in subgroup analyses. For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96-3.19, P = 0.07) and 1.76 (95% CI, 1.29-2.40, P < 0.001), respectively. Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.

No MeSH data available.


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Risk ratios for stroke, CHD, and CVD with increased CRP levels.
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f3-cmc-suppl.3-2014-035: Risk ratios for stroke, CHD, and CVD with increased CRP levels.

Mentions: The overall association between elevated CRP levels and stroke was significant using the random-effects model with the six stroke studies (risk ratio = 1.39 [95% CI, 1.09–1.77], P = 0.008) (Fig. 3). We did not find significant heterogeneity of effect among the studies (I2 = 32%, P = 0.19). Only one study measured mortality as an outcome, but the association was unchanged if the study was excluded from the analysis. Regarding CHD, the random-effects association was not significant, with wide CIs, when including four studies (risk ratio = 1.75 [95% CI, 0.96–3.19], P = 0.07). There was significant heterogeneity of effect (I2 = 72%, P = 0.01). The risk ratio for CVD was 1.76 (95% CI, 1.29–2.40, P < 0.001), and we found no heterogeneity of effect (I2 = 49%, P = 0.14) among studies.


C-reactive protein and cardiovascular disease in East asians: a systematic review.

Saito I, Maruyama K, Eguchi E - Clin Med Insights Cardiol (2015)

Risk ratios for stroke, CHD, and CVD with increased CRP levels.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4319655&req=5

f3-cmc-suppl.3-2014-035: Risk ratios for stroke, CHD, and CVD with increased CRP levels.
Mentions: The overall association between elevated CRP levels and stroke was significant using the random-effects model with the six stroke studies (risk ratio = 1.39 [95% CI, 1.09–1.77], P = 0.008) (Fig. 3). We did not find significant heterogeneity of effect among the studies (I2 = 32%, P = 0.19). Only one study measured mortality as an outcome, but the association was unchanged if the study was excluded from the analysis. Regarding CHD, the random-effects association was not significant, with wide CIs, when including four studies (risk ratio = 1.75 [95% CI, 0.96–3.19], P = 0.07). There was significant heterogeneity of effect (I2 = 72%, P = 0.01). The risk ratio for CVD was 1.76 (95% CI, 1.29–2.40, P < 0.001), and we found no heterogeneity of effect (I2 = 49%, P = 0.14) among studies.

Bottom Line: PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models.For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96-3.19, P = 0.07) and 1.76 (95% CI, 1.29-2.40, P < 0.001), respectively.Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.

View Article: PubMed Central - PubMed

Affiliation: Department of Basic Nursing and Health Science, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.

ABSTRACT
Elevated C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular disease (CVD) in Caucasians; however, evidence is lacking for East Asians, who have low CRP levels. PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models. The overall association between CRP levels and stroke was significant in six studies (risk ratio = 1.40 [95% confidence interval {CI}, 1.10-1.77], P = 0.008). The association with ischemic stroke was more evident in subgroup analyses. For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96-3.19, P = 0.07) and 1.76 (95% CI, 1.29-2.40, P < 0.001), respectively. Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.

No MeSH data available.


Related in: MedlinePlus