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C-reactive protein and cardiovascular disease in East asians: a systematic review.

Saito I, Maruyama K, Eguchi E - Clin Med Insights Cardiol (2015)

Bottom Line: PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models.For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96-3.19, P = 0.07) and 1.76 (95% CI, 1.29-2.40, P < 0.001), respectively.Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.

View Article: PubMed Central - PubMed

Affiliation: Department of Basic Nursing and Health Science, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.

ABSTRACT
Elevated C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular disease (CVD) in Caucasians; however, evidence is lacking for East Asians, who have low CRP levels. PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models. The overall association between CRP levels and stroke was significant in six studies (risk ratio = 1.40 [95% confidence interval {CI}, 1.10-1.77], P = 0.008). The association with ischemic stroke was more evident in subgroup analyses. For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96-3.19, P = 0.07) and 1.76 (95% CI, 1.29-2.40, P < 0.001), respectively. Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.

No MeSH data available.


Related in: MedlinePlus

Flow of study selection.
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f1-cmc-suppl.3-2014-035: Flow of study selection.

Mentions: Our searches retrieved 208 PubMed citations and 2 Google Scholar citations. In all, 22 of them met our inclusion criteria without duplicates (Fig. 1). We excluded 14 articles after a more detailed evaluation, and finally, 8 articles were acceptable for the meta-analysis.9–16


C-reactive protein and cardiovascular disease in East asians: a systematic review.

Saito I, Maruyama K, Eguchi E - Clin Med Insights Cardiol (2015)

Flow of study selection.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4319655&req=5

f1-cmc-suppl.3-2014-035: Flow of study selection.
Mentions: Our searches retrieved 208 PubMed citations and 2 Google Scholar citations. In all, 22 of them met our inclusion criteria without duplicates (Fig. 1). We excluded 14 articles after a more detailed evaluation, and finally, 8 articles were acceptable for the meta-analysis.9–16

Bottom Line: PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models.For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96-3.19, P = 0.07) and 1.76 (95% CI, 1.29-2.40, P < 0.001), respectively.Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.

View Article: PubMed Central - PubMed

Affiliation: Department of Basic Nursing and Health Science, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.

ABSTRACT
Elevated C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular disease (CVD) in Caucasians; however, evidence is lacking for East Asians, who have low CRP levels. PubMed and Google Scholar searches were conducted (1966 through September 2014), and eight prospective studies in East Asian countries (China, Hong Kong, Japan, Korea, Macao, Mongolia, and Taiwan) that documented risk ratios of elevated CRP for CVD were included for meta-analysis with random-effects models. The overall association between CRP levels and stroke was significant in six studies (risk ratio = 1.40 [95% confidence interval {CI}, 1.10-1.77], P = 0.008). The association with ischemic stroke was more evident in subgroup analyses. For coronary heart disease (CHD) and CVD, the risk ratio was 1.75 (95% CI, 0.96-3.19, P = 0.07) and 1.76 (95% CI, 1.29-2.40, P < 0.001), respectively. Although East Asians have low CRP levels, this meta-analysis shows that elevated CRP levels were significantly associated with an increased risk of stroke, primarily ischemic stroke.

No MeSH data available.


Related in: MedlinePlus