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Efficacy and Tolerability of Steroid-Free, Over-the-Counter Treatment Formulations in Infants and Children With Atopic Dermatitis.

Weber TM, Herndon JH, Ewer M, Stephens TJ, Flick I, Filbry A, Neufang G, Schoelermann AM - J Dermatol Nurses Assoc (2015)

Bottom Line: Body Cream significantly improved skin hydration and reduced itching, burning/stinging, erythema, and tactile roughness.Both products were safe and well tolerated.These products provide steroid-free, nonprescription therapy for the maintenance and treatment of acute eczema and were proven effective and safe in infants as young as 3 months.

View Article: PubMed Central - PubMed

Affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.

ABSTRACT

Background: Two steroid-free, over-the-counter skin protectant products have been developed for the care and treatment of atopic dermatitis (AD)-Eucerin Eczema Relief Body Crème (Body Cream) for daily skin moisturization and Eucerin Eczema Relief Instant Therapy cream (Instant Therapy) for treatment of AD flare-ups. We tested the efficacy and tolerability of these formulations in infants and children with AD.

Methods: Study 1: Body Cream was applied twice daily to the lower legs of 64 children with a history of AD (aged 3 months to 12 years) for 14 days. Study 2: Instant Therapy was applied to active lesions and surrounding skin of 29 children (aged 3 months to 12 years) with active atopic lesions. Assessments were performed at baseline and Days 7 and 14. Symptoms were assessed using the Atopic Dermatitis Severity Index in Study 2.

Results: Body Cream significantly improved skin hydration and reduced itching, burning/stinging, erythema, and tactile roughness. Instant Therapy significantly improved skin hydration and AD symptoms, notably pruritus, erythema, and lichenification. Both products were safe and well tolerated.

Discussion: Body Cream and Instant Therapy were effective and well tolerated in the treatment of AD in children. These products provide steroid-free, nonprescription therapy for the maintenance and treatment of acute eczema and were proven effective and safe in infants as young as 3 months.

No MeSH data available.


Related in: MedlinePlus

Improvement in active lesions after 2 weeks of Instant Therapy treatment. Improvements seen at Day 14 in erythema and exudation of the lower lateral leg (A), lichenification of the lower leg (B), and erythema and scaling on the back of the neck (C).
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Figure 7: Improvement in active lesions after 2 weeks of Instant Therapy treatment. Improvements seen at Day 14 in erythema and exudation of the lower lateral leg (A), lichenification of the lower leg (B), and erythema and scaling on the back of the neck (C).

Mentions: Instant Therapy application significantly improved AD severity, decreasing total ADSI scores by 41.8% and 58.4% at Days 7 and 14, respectively (p < .001; Figure 6). Improvement in overall score was observed in 93.1% of subjects at Week 2. Treatment with Instant Therapy significantly improved the individual symptoms of AD, with the greatest improvements observed for pruritus (64.9%), erythema (54.0%), and lichenification (57.1%) at Day 14 (p < .001) and excoriation (73.6%) at Day 7 (p = .004; Figure 6). The visible improvement in the appearance of active lesions and the surrounding skin after 2 weeks of Instant Therapy can be seen in Figure 7; before and after photographs show examples of improvements in erythema, excoriation, lichenification, and lesion intensity after 2 weeks of treatment.


Efficacy and Tolerability of Steroid-Free, Over-the-Counter Treatment Formulations in Infants and Children With Atopic Dermatitis.

Weber TM, Herndon JH, Ewer M, Stephens TJ, Flick I, Filbry A, Neufang G, Schoelermann AM - J Dermatol Nurses Assoc (2015)

Improvement in active lesions after 2 weeks of Instant Therapy treatment. Improvements seen at Day 14 in erythema and exudation of the lower lateral leg (A), lichenification of the lower leg (B), and erythema and scaling on the back of the neck (C).
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4318661&req=5

Figure 7: Improvement in active lesions after 2 weeks of Instant Therapy treatment. Improvements seen at Day 14 in erythema and exudation of the lower lateral leg (A), lichenification of the lower leg (B), and erythema and scaling on the back of the neck (C).
Mentions: Instant Therapy application significantly improved AD severity, decreasing total ADSI scores by 41.8% and 58.4% at Days 7 and 14, respectively (p < .001; Figure 6). Improvement in overall score was observed in 93.1% of subjects at Week 2. Treatment with Instant Therapy significantly improved the individual symptoms of AD, with the greatest improvements observed for pruritus (64.9%), erythema (54.0%), and lichenification (57.1%) at Day 14 (p < .001) and excoriation (73.6%) at Day 7 (p = .004; Figure 6). The visible improvement in the appearance of active lesions and the surrounding skin after 2 weeks of Instant Therapy can be seen in Figure 7; before and after photographs show examples of improvements in erythema, excoriation, lichenification, and lesion intensity after 2 weeks of treatment.

Bottom Line: Body Cream significantly improved skin hydration and reduced itching, burning/stinging, erythema, and tactile roughness.Both products were safe and well tolerated.These products provide steroid-free, nonprescription therapy for the maintenance and treatment of acute eczema and were proven effective and safe in infants as young as 3 months.

View Article: PubMed Central - PubMed

Affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.

ABSTRACT

Background: Two steroid-free, over-the-counter skin protectant products have been developed for the care and treatment of atopic dermatitis (AD)-Eucerin Eczema Relief Body Crème (Body Cream) for daily skin moisturization and Eucerin Eczema Relief Instant Therapy cream (Instant Therapy) for treatment of AD flare-ups. We tested the efficacy and tolerability of these formulations in infants and children with AD.

Methods: Study 1: Body Cream was applied twice daily to the lower legs of 64 children with a history of AD (aged 3 months to 12 years) for 14 days. Study 2: Instant Therapy was applied to active lesions and surrounding skin of 29 children (aged 3 months to 12 years) with active atopic lesions. Assessments were performed at baseline and Days 7 and 14. Symptoms were assessed using the Atopic Dermatitis Severity Index in Study 2.

Results: Body Cream significantly improved skin hydration and reduced itching, burning/stinging, erythema, and tactile roughness. Instant Therapy significantly improved skin hydration and AD symptoms, notably pruritus, erythema, and lichenification. Both products were safe and well tolerated.

Discussion: Body Cream and Instant Therapy were effective and well tolerated in the treatment of AD in children. These products provide steroid-free, nonprescription therapy for the maintenance and treatment of acute eczema and were proven effective and safe in infants as young as 3 months.

No MeSH data available.


Related in: MedlinePlus