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Efficacy and Tolerability of Steroid-Free, Over-the-Counter Treatment Formulations in Infants and Children With Atopic Dermatitis.

Weber TM, Herndon JH, Ewer M, Stephens TJ, Flick I, Filbry A, Neufang G, Schoelermann AM - J Dermatol Nurses Assoc (2015)

Bottom Line: Body Cream significantly improved skin hydration and reduced itching, burning/stinging, erythema, and tactile roughness.Both products were safe and well tolerated.These products provide steroid-free, nonprescription therapy for the maintenance and treatment of acute eczema and were proven effective and safe in infants as young as 3 months.

View Article: PubMed Central - PubMed

Affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.

ABSTRACT

Background: Two steroid-free, over-the-counter skin protectant products have been developed for the care and treatment of atopic dermatitis (AD)-Eucerin Eczema Relief Body Crème (Body Cream) for daily skin moisturization and Eucerin Eczema Relief Instant Therapy cream (Instant Therapy) for treatment of AD flare-ups. We tested the efficacy and tolerability of these formulations in infants and children with AD.

Methods: Study 1: Body Cream was applied twice daily to the lower legs of 64 children with a history of AD (aged 3 months to 12 years) for 14 days. Study 2: Instant Therapy was applied to active lesions and surrounding skin of 29 children (aged 3 months to 12 years) with active atopic lesions. Assessments were performed at baseline and Days 7 and 14. Symptoms were assessed using the Atopic Dermatitis Severity Index in Study 2.

Results: Body Cream significantly improved skin hydration and reduced itching, burning/stinging, erythema, and tactile roughness. Instant Therapy significantly improved skin hydration and AD symptoms, notably pruritus, erythema, and lichenification. Both products were safe and well tolerated.

Discussion: Body Cream and Instant Therapy were effective and well tolerated in the treatment of AD in children. These products provide steroid-free, nonprescription therapy for the maintenance and treatment of acute eczema and were proven effective and safe in infants as young as 3 months.

No MeSH data available.


Related in: MedlinePlus

Product assessment questionnaire of Body Cream. Parents completed a questionnaire on the qualities of Body Cream at Day 14. Percentages show the combined responses that agreed or strongly agreed with the statements; <5% disagreed with any statement, and the remainder neither agreed nor disagreed. The proportion of all responses indicating agreement was statistically significant.
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Figure 4: Product assessment questionnaire of Body Cream. Parents completed a questionnaire on the qualities of Body Cream at Day 14. Percentages show the combined responses that agreed or strongly agreed with the statements; <5% disagreed with any statement, and the remainder neither agreed nor disagreed. The proportion of all responses indicating agreement was statistically significant.

Mentions: The questionnaire analysis showed that a statistically significant proportion of parents indicated agreement (strongly agree or agree) with statements supporting the efficacy and tolerability of Body Cream (Figure 4). Overall, 94% of parents/guardians confirmed that the product effectively moisturized their child’s skin, 94% stated that it did not irritate skin, 91% reported that it soothed skin, 88% thought that it protected their child’s skin from dryness, and 100% agreed that it was gentle enough to use every day.


Efficacy and Tolerability of Steroid-Free, Over-the-Counter Treatment Formulations in Infants and Children With Atopic Dermatitis.

Weber TM, Herndon JH, Ewer M, Stephens TJ, Flick I, Filbry A, Neufang G, Schoelermann AM - J Dermatol Nurses Assoc (2015)

Product assessment questionnaire of Body Cream. Parents completed a questionnaire on the qualities of Body Cream at Day 14. Percentages show the combined responses that agreed or strongly agreed with the statements; <5% disagreed with any statement, and the remainder neither agreed nor disagreed. The proportion of all responses indicating agreement was statistically significant.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4318661&req=5

Figure 4: Product assessment questionnaire of Body Cream. Parents completed a questionnaire on the qualities of Body Cream at Day 14. Percentages show the combined responses that agreed or strongly agreed with the statements; <5% disagreed with any statement, and the remainder neither agreed nor disagreed. The proportion of all responses indicating agreement was statistically significant.
Mentions: The questionnaire analysis showed that a statistically significant proportion of parents indicated agreement (strongly agree or agree) with statements supporting the efficacy and tolerability of Body Cream (Figure 4). Overall, 94% of parents/guardians confirmed that the product effectively moisturized their child’s skin, 94% stated that it did not irritate skin, 91% reported that it soothed skin, 88% thought that it protected their child’s skin from dryness, and 100% agreed that it was gentle enough to use every day.

Bottom Line: Body Cream significantly improved skin hydration and reduced itching, burning/stinging, erythema, and tactile roughness.Both products were safe and well tolerated.These products provide steroid-free, nonprescription therapy for the maintenance and treatment of acute eczema and were proven effective and safe in infants as young as 3 months.

View Article: PubMed Central - PubMed

Affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.

ABSTRACT

Background: Two steroid-free, over-the-counter skin protectant products have been developed for the care and treatment of atopic dermatitis (AD)-Eucerin Eczema Relief Body Crème (Body Cream) for daily skin moisturization and Eucerin Eczema Relief Instant Therapy cream (Instant Therapy) for treatment of AD flare-ups. We tested the efficacy and tolerability of these formulations in infants and children with AD.

Methods: Study 1: Body Cream was applied twice daily to the lower legs of 64 children with a history of AD (aged 3 months to 12 years) for 14 days. Study 2: Instant Therapy was applied to active lesions and surrounding skin of 29 children (aged 3 months to 12 years) with active atopic lesions. Assessments were performed at baseline and Days 7 and 14. Symptoms were assessed using the Atopic Dermatitis Severity Index in Study 2.

Results: Body Cream significantly improved skin hydration and reduced itching, burning/stinging, erythema, and tactile roughness. Instant Therapy significantly improved skin hydration and AD symptoms, notably pruritus, erythema, and lichenification. Both products were safe and well tolerated.

Discussion: Body Cream and Instant Therapy were effective and well tolerated in the treatment of AD in children. These products provide steroid-free, nonprescription therapy for the maintenance and treatment of acute eczema and were proven effective and safe in infants as young as 3 months.

No MeSH data available.


Related in: MedlinePlus