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Multidrug-resistant tuberculosis around the world: what progress has been made?

Falzon D, Mirzayev F, Wares F, Baena IG, Zignol M, Linh N, Weyer K, Jaramillo E, Floyd K, Raviglione M - Eur. Respir. J. (2014)

Bottom Line: Multidrug-resistant tuberculosis (MDR-TB) (resistance to at least isoniazid and rifampicin) will influence the future of global TB control. 88% of estimated MDR-TB cases occur in middle- or high-income countries, and 60% occur in Brazil, China, India, the Russian Federation and South Africa.Notification, treatment enrolment and outcome data were summarised for 30 countries, accounting for >90% of the estimated MDR-TB cases among notified TB cases worldwide.Median treatment success was 53% (interquartile range 40-70%) in the 25 countries reporting data for 30 021 MDR-TB cases who started treatment in 2010.

View Article: PubMed Central - PubMed

Affiliation: Global TB Programme, World Health Organization, Geneva, Switzerland falzond@who.int.

No MeSH data available.


Related in: MedlinePlus

Multidrug-resistant tuberculosis (MDR-TB) cases and additional rifampicin-resistant TB cases detected, compared with TB cases enrolled on MDR-TB treatment, trend in target countries, 2009−2012.
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Figure 2: Multidrug-resistant tuberculosis (MDR-TB) cases and additional rifampicin-resistant TB cases detected, compared with TB cases enrolled on MDR-TB treatment, trend in target countries, 2009−2012.

Mentions: In 2012, the case detection of MDR-TB varied between countries from <1% and >100% of the estimated caseload (median 14.4% (IQR 5.8–50.2%)) (fig. S2 of the online supplementary material). Eight countries (Belarus, Kazakhstan, Kyrgyzstan, Peru, the Republic of Korea, the Republic of Moldova, South Africa and the Ukraine) detected >50% of their estimated cases, which is the target threshold for all countries by 2015. In 2012, a total of 77 956 MDR-TB cases was detected plus an additional 8986 rifampicin-resistant TB cases detected using Xpert MTB/RIF alone, a doubling in reported cases in the 30 countries studied compared with 2009 (table 2 and fig. 2). Overall, the mean annual percentage increase was 27% during 2010–2012, but exceeded 100% in Angola, India, Myanmar, Nigeria, Pakistan and Viet Nam. However, MDR-TB case detection in 2012 was <10% of the estimated number in Angola, Nigeria and Viet Nam. 15 of the 30 countries reported at least one XDR-TB case in 2012; out of the total 2077 XDR-TB cases reported, 1596 (77%) were reported by South Africa alone (data by country not shown).


Multidrug-resistant tuberculosis around the world: what progress has been made?

Falzon D, Mirzayev F, Wares F, Baena IG, Zignol M, Linh N, Weyer K, Jaramillo E, Floyd K, Raviglione M - Eur. Respir. J. (2014)

Multidrug-resistant tuberculosis (MDR-TB) cases and additional rifampicin-resistant TB cases detected, compared with TB cases enrolled on MDR-TB treatment, trend in target countries, 2009−2012.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318660&req=5

Figure 2: Multidrug-resistant tuberculosis (MDR-TB) cases and additional rifampicin-resistant TB cases detected, compared with TB cases enrolled on MDR-TB treatment, trend in target countries, 2009−2012.
Mentions: In 2012, the case detection of MDR-TB varied between countries from <1% and >100% of the estimated caseload (median 14.4% (IQR 5.8–50.2%)) (fig. S2 of the online supplementary material). Eight countries (Belarus, Kazakhstan, Kyrgyzstan, Peru, the Republic of Korea, the Republic of Moldova, South Africa and the Ukraine) detected >50% of their estimated cases, which is the target threshold for all countries by 2015. In 2012, a total of 77 956 MDR-TB cases was detected plus an additional 8986 rifampicin-resistant TB cases detected using Xpert MTB/RIF alone, a doubling in reported cases in the 30 countries studied compared with 2009 (table 2 and fig. 2). Overall, the mean annual percentage increase was 27% during 2010–2012, but exceeded 100% in Angola, India, Myanmar, Nigeria, Pakistan and Viet Nam. However, MDR-TB case detection in 2012 was <10% of the estimated number in Angola, Nigeria and Viet Nam. 15 of the 30 countries reported at least one XDR-TB case in 2012; out of the total 2077 XDR-TB cases reported, 1596 (77%) were reported by South Africa alone (data by country not shown).

Bottom Line: Multidrug-resistant tuberculosis (MDR-TB) (resistance to at least isoniazid and rifampicin) will influence the future of global TB control. 88% of estimated MDR-TB cases occur in middle- or high-income countries, and 60% occur in Brazil, China, India, the Russian Federation and South Africa.Notification, treatment enrolment and outcome data were summarised for 30 countries, accounting for >90% of the estimated MDR-TB cases among notified TB cases worldwide.Median treatment success was 53% (interquartile range 40-70%) in the 25 countries reporting data for 30 021 MDR-TB cases who started treatment in 2010.

View Article: PubMed Central - PubMed

Affiliation: Global TB Programme, World Health Organization, Geneva, Switzerland falzond@who.int.

No MeSH data available.


Related in: MedlinePlus