Limits...
Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis.

Torres M, García-García L, Cruz-Hervert P, Guio H, Carranza C, Ferreyra-Reyes L, Canizales S, Molina S, Ferreira-Guerrero E, Téllez N, Montero-Campos R, Delgado-Sánchez G, Mongua-Rodriguez N, Sifuentes-Osornio J, Ponce-de Leon A, Sada E, Young DB, Wilkinson RJ - Eur. Respir. J. (2014)

Bottom Line: We designed a two-group, two-arm, randomised clinical study of tuberculin skin test-positive participants: 26 with documented contact with TB patients and 34 with non-documented contact.During isoniazid therapy, a significant increase from baseline in the proportion of IFN-γ responders to the 10-kDa culture filtrate protein, Rv2031, Rv0849, Rv1986, Rv2659c, Rv2693c and the recombinant Rv1737 protein was observed (p⩽0.05).The peptide pool of Rv0849 and Rv1737 recombinant proteins induced the highest percentage of IFN-γ responders after isoniazid therapy.

View Article: PubMed Central - PubMed

Affiliation: Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of study population. a) Documented contacts. b) Non-documented contacts.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4318657&req=5

Figure 1: Flow diagram of study population. a) Documented contacts. b) Non-documented contacts.

Mentions: We analysed information on 60 individuals who provided all blood samples. A flow diagram displaying the numbers of individuals at enrolment, intervention allocation, follow-up and analysis is shown in figure 1. Most of the characteristics of participants were similar between groups (table 2), but a significantly higher proportion of women were allocated to group C. Non-documented contacts were older and with greater TST induration than documented contacts. 56 individuals ingested 80% or more of the indicated pills, and four individuals ingested between 50% and 79%. Measurements of isoniazid metabolites in urine were positive in >90% of the determinations.


Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis.

Torres M, García-García L, Cruz-Hervert P, Guio H, Carranza C, Ferreyra-Reyes L, Canizales S, Molina S, Ferreira-Guerrero E, Téllez N, Montero-Campos R, Delgado-Sánchez G, Mongua-Rodriguez N, Sifuentes-Osornio J, Ponce-de Leon A, Sada E, Young DB, Wilkinson RJ - Eur. Respir. J. (2014)

Flow diagram of study population. a) Documented contacts. b) Non-documented contacts.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318657&req=5

Figure 1: Flow diagram of study population. a) Documented contacts. b) Non-documented contacts.
Mentions: We analysed information on 60 individuals who provided all blood samples. A flow diagram displaying the numbers of individuals at enrolment, intervention allocation, follow-up and analysis is shown in figure 1. Most of the characteristics of participants were similar between groups (table 2), but a significantly higher proportion of women were allocated to group C. Non-documented contacts were older and with greater TST induration than documented contacts. 56 individuals ingested 80% or more of the indicated pills, and four individuals ingested between 50% and 79%. Measurements of isoniazid metabolites in urine were positive in >90% of the determinations.

Bottom Line: We designed a two-group, two-arm, randomised clinical study of tuberculin skin test-positive participants: 26 with documented contact with TB patients and 34 with non-documented contact.During isoniazid therapy, a significant increase from baseline in the proportion of IFN-γ responders to the 10-kDa culture filtrate protein, Rv2031, Rv0849, Rv1986, Rv2659c, Rv2693c and the recombinant Rv1737 protein was observed (p⩽0.05).The peptide pool of Rv0849 and Rv1737 recombinant proteins induced the highest percentage of IFN-γ responders after isoniazid therapy.

View Article: PubMed Central - PubMed

Affiliation: Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.

No MeSH data available.


Related in: MedlinePlus