Cell type-specific effects of adenosine on cortical neurons.
Bottom Line: Although the effect of adenosine on subcortical areas has been previously described, the effects on cortical neurons have not been addressed systematically to date.We found that adenosine, via the A1 receptor, exerts differential effects depending on neuronal cell type and laminar location.These studies of the action of adenosine at the postsynaptic level may contribute to the understanding of the changes in cortical circuit functioning that take place between sleep and awakening.
Affiliation: Forschungszentrum Jülich, Institute of Neuroscience and Medicine, INM-2, D-52425 Jülich, Germany Current address: Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Science, 1105 BA Amsterdam, The Netherlands.Show MeSH
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Mentions: The present study demonstrates that the neuromodulator adenosine, which plays an important role in sleep homeostasis, does not exercise a general inhibitory tone on the cortical network as previously hypothesized, but rather specifically modulates each pyramidal neuron subtype in a distinct fashion (Fig. 10). Our results from interneurons and pyramidal neurons in the rat mPFC are likely to apply to neurons in other cortical areas, as we obtained similar results for the rat somatosensory cortex. Adenosine decreased cellular excitability of most pyramidal neuron subtypes via adenosine A1 receptors that lead to the opening of potassium channels. Furthermore, passive properties like cellular input resistance, membrane time constant, RMP, and cellular excitability were correlated with the size of the adenosine response, as well as the relative field span of the apical dendritic tuft.Figure 10.
Affiliation: Forschungszentrum Jülich, Institute of Neuroscience and Medicine, INM-2, D-52425 Jülich, Germany Current address: Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Science, 1105 BA Amsterdam, The Netherlands.