Cell type-specific effects of adenosine on cortical neurons.
Bottom Line: Although the effect of adenosine on subcortical areas has been previously described, the effects on cortical neurons have not been addressed systematically to date.We found that adenosine, via the A1 receptor, exerts differential effects depending on neuronal cell type and laminar location.These studies of the action of adenosine at the postsynaptic level may contribute to the understanding of the changes in cortical circuit functioning that take place between sleep and awakening.
Affiliation: Forschungszentrum Jülich, Institute of Neuroscience and Medicine, INM-2, D-52425 Jülich, Germany Current address: Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Science, 1105 BA Amsterdam, The Netherlands.Show MeSH
Mentions: In the rat mPFC, layer 2 is clearly distinguishable from layer 3 as a thin dark band that is densely packed with neuron somata; it is located directly beneath layer 1 (Fig. 2A). Layer 2 is the thinnest layer of the prefrontal cortex containing only a few “rows” of pyramidal neurons. On a qualitative level, the density of neuron somata is lower in layer 3 than in layer 2 as can be seen at both the microscopic and macroscopic levels (Fig. 2A). Morphologically, L2 pyramidal neurons differ from L3 pyramidal neurons in the field span of their apical and basal dendrites: The apical dendritic tree of L2 pyramidal neurons has typically a much larger field span than the basal dendritic tree, whereas this ratio is smaller or reversed for L3 pyramidal neurons (Fig. 2B, see accompanying paper for more details; Van Aerde and Feldmeyer 2013).Figure 2.
Affiliation: Forschungszentrum Jülich, Institute of Neuroscience and Medicine, INM-2, D-52425 Jülich, Germany Current address: Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Science, 1105 BA Amsterdam, The Netherlands.