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New Chemometrics Mode Based on Adjacent Data Points' Differences for the Simultaneous Determination of Clopidogrel, Atorvastatin, and Aspirin in their Combined Ternary Drug Formulation.

Nejem RM, Issa MM, Shanab AA, Stefan-Van Staden RI, Aboul-Enein HY - Sci Pharm (2014)

Bottom Line: The method has been successfully applied to the simultaneous determination of ternary mixtures of aspirin, clopidogrel bisulphate, and atorvastatin calcium.The analytical characteristics of the method were calculated.The results showed that the new method is simple, rapid, accurate, and precise.

View Article: PubMed Central - PubMed

Affiliation: Analytical Chemistry, Department of Chemistry, Alaqsa University, P.O.Box 4051, Gaza, Palestine.

ABSTRACT
A new method is proposed for the analysis of a ternary mixture composed of clopidogrel, atorvastatin, and aspirin without prior separation steps. The method combines the advantages of the mean centering of ratio spectra and derivative spectrophotometric methods. It is based on using the difference between adjacent data points in the absorbance spectra. The principal advantage of this method is the use of absorbance data, and not derivative data; hence the signal-to-noise ratio is not diminished. The mathematical explanation of the procedure is illustrated. Beer's law was valid in the concentration range 0.3-35 μg.mL(-1) for CLOP, 0.5-30 μg.mL(-1) for ATOR, and 1-40 μg.mL(-1) for ASP. Mean recoveries were obtained as 100.2, 100.1, and 100.2% for CLOP, ATOR, and ASP, respectively, in the prepared synthetic mixtures. The method has been successfully applied to the simultaneous determination of ternary mixtures of aspirin, clopidogrel bisulphate, and atorvastatin calcium. The analytical characteristics of the method were calculated. The results showed that the new method is simple, rapid, accurate, and precise.

No MeSH data available.


Related in: MedlinePlus

The zero-order spectra (5 μg.mL-1) of (1) CLOP; (2) ATOR; (3) ASP in methanol
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Figure 1: The zero-order spectra (5 μg.mL-1) of (1) CLOP; (2) ATOR; (3) ASP in methanol

Mentions: As Fig. 1 shows, the absorption spectra of CLOP, ATOR, and ASP in methanol overlapped in the region 200–340 nm. The focus of this work was to develop a new method to resolve this overlapping and furthermore, to develop the MCR method for the resolution of these drugs in their ternary mixtures.


New Chemometrics Mode Based on Adjacent Data Points' Differences for the Simultaneous Determination of Clopidogrel, Atorvastatin, and Aspirin in their Combined Ternary Drug Formulation.

Nejem RM, Issa MM, Shanab AA, Stefan-Van Staden RI, Aboul-Enein HY - Sci Pharm (2014)

The zero-order spectra (5 μg.mL-1) of (1) CLOP; (2) ATOR; (3) ASP in methanol
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318198&req=5

Figure 1: The zero-order spectra (5 μg.mL-1) of (1) CLOP; (2) ATOR; (3) ASP in methanol
Mentions: As Fig. 1 shows, the absorption spectra of CLOP, ATOR, and ASP in methanol overlapped in the region 200–340 nm. The focus of this work was to develop a new method to resolve this overlapping and furthermore, to develop the MCR method for the resolution of these drugs in their ternary mixtures.

Bottom Line: The method has been successfully applied to the simultaneous determination of ternary mixtures of aspirin, clopidogrel bisulphate, and atorvastatin calcium.The analytical characteristics of the method were calculated.The results showed that the new method is simple, rapid, accurate, and precise.

View Article: PubMed Central - PubMed

Affiliation: Analytical Chemistry, Department of Chemistry, Alaqsa University, P.O.Box 4051, Gaza, Palestine.

ABSTRACT
A new method is proposed for the analysis of a ternary mixture composed of clopidogrel, atorvastatin, and aspirin without prior separation steps. The method combines the advantages of the mean centering of ratio spectra and derivative spectrophotometric methods. It is based on using the difference between adjacent data points in the absorbance spectra. The principal advantage of this method is the use of absorbance data, and not derivative data; hence the signal-to-noise ratio is not diminished. The mathematical explanation of the procedure is illustrated. Beer's law was valid in the concentration range 0.3-35 μg.mL(-1) for CLOP, 0.5-30 μg.mL(-1) for ATOR, and 1-40 μg.mL(-1) for ASP. Mean recoveries were obtained as 100.2, 100.1, and 100.2% for CLOP, ATOR, and ASP, respectively, in the prepared synthetic mixtures. The method has been successfully applied to the simultaneous determination of ternary mixtures of aspirin, clopidogrel bisulphate, and atorvastatin calcium. The analytical characteristics of the method were calculated. The results showed that the new method is simple, rapid, accurate, and precise.

No MeSH data available.


Related in: MedlinePlus