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Paraneoplastic optic neuritis as the first manifestation of periampullary carcinoma.

Paul R, Ghosh AK, Sinha A, Bhattacharya R - Int J Appl Basic Med Res (2015 Jan-Apr)

Bottom Line: Prompt treatment of the malignancy is the only effective therapy for the condition.Visual loss, once established usually becomes irreversible.This is probably the first report of this association in the medical literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Medical College Kolkata, Kolkata, West Bengal, India.

ABSTRACT
Paraneoplastic optic neuritis is a rare phenomenon that often presents as a diagnostic challenge. It has been mostly reported with small cell cancers or thymoma. Prompt treatment of the malignancy is the only effective therapy for the condition. Visual loss, once established usually becomes irreversible. We here report a case of paraneoplastic optic neuritis in a 40-year-old female with periampullary carcinoma. This is probably the first report of this association in the medical literature.

No MeSH data available.


Related in: MedlinePlus

Fundus photography of left eye of the patient shows edematous disc with blurred margins (green arrow) and tortuous vessels, suggestive of optic neuritis
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Figure 1: Fundus photography of left eye of the patient shows edematous disc with blurred margins (green arrow) and tortuous vessels, suggestive of optic neuritis

Mentions: A 40-year-old female housewife presented with sudden onset painless dimness of vision of left eye for 1-month. She had no redness of the eye and no restriction of ocular movement. However, on moving the eye there was mild retro-orbital pain. The left pupil was sluggishly reactive to light. The right eye was completely normal. Ophthalmoscopy of the left eye revealed swelling of the optic disc [Figure 1]. This, along with other clinical features, was suggestive of optic neuritis. The patient was started on oral steroids and her visual dimness slightly improved. Magnetic resonance imaging of the brain did not reveal any other lesion. There was no mass in the cavernous sinus or the orbit. The patient had no nystagmus or proptosis.


Paraneoplastic optic neuritis as the first manifestation of periampullary carcinoma.

Paul R, Ghosh AK, Sinha A, Bhattacharya R - Int J Appl Basic Med Res (2015 Jan-Apr)

Fundus photography of left eye of the patient shows edematous disc with blurred margins (green arrow) and tortuous vessels, suggestive of optic neuritis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318110&req=5

Figure 1: Fundus photography of left eye of the patient shows edematous disc with blurred margins (green arrow) and tortuous vessels, suggestive of optic neuritis
Mentions: A 40-year-old female housewife presented with sudden onset painless dimness of vision of left eye for 1-month. She had no redness of the eye and no restriction of ocular movement. However, on moving the eye there was mild retro-orbital pain. The left pupil was sluggishly reactive to light. The right eye was completely normal. Ophthalmoscopy of the left eye revealed swelling of the optic disc [Figure 1]. This, along with other clinical features, was suggestive of optic neuritis. The patient was started on oral steroids and her visual dimness slightly improved. Magnetic resonance imaging of the brain did not reveal any other lesion. There was no mass in the cavernous sinus or the orbit. The patient had no nystagmus or proptosis.

Bottom Line: Prompt treatment of the malignancy is the only effective therapy for the condition.Visual loss, once established usually becomes irreversible.This is probably the first report of this association in the medical literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Medical College Kolkata, Kolkata, West Bengal, India.

ABSTRACT
Paraneoplastic optic neuritis is a rare phenomenon that often presents as a diagnostic challenge. It has been mostly reported with small cell cancers or thymoma. Prompt treatment of the malignancy is the only effective therapy for the condition. Visual loss, once established usually becomes irreversible. We here report a case of paraneoplastic optic neuritis in a 40-year-old female with periampullary carcinoma. This is probably the first report of this association in the medical literature.

No MeSH data available.


Related in: MedlinePlus