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Leukemic gingival enlargement: Report of a rare case with review of literature.

Hasan S, Khan NI, Reddy LB - Int J Appl Basic Med Res (2015 Jan-Apr)

Bottom Line: Although gingival changes may be related to local factors in the oral cavity, it can also be an expression of systemic conditions such as blood dyscrasias, endocrinal imbalance, and nutritional deficiencies.Oral changes may be the first and only presenting signs in leukemic patients.This paper aims to throw light on an interesting case of acute leukemia diagnosed on the basis of oral signs and emphasizes the importance of thorough oral examination to identify the threatening condition.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, Okhla, New Delhi, India.

ABSTRACT
Oral cavity functions as an early indicator for a variety of systemic diseases. Early and accurate diagnosis of these underlying systemic disorders entails thorough examination of the oral mucosa, gingiva, teeth, tongue and other oral tissues. Although gingival changes may be related to local factors in the oral cavity, it can also be an expression of systemic conditions such as blood dyscrasias, endocrinal imbalance, and nutritional deficiencies. Leukemia, a malignancy of white blood cells is a dreadful disease, which, if not diagnosed properly and treated early may result in significant morbidity and mortality. Oral changes may be the first and only presenting signs in leukemic patients. This paper aims to throw light on an interesting case of acute leukemia diagnosed on the basis of oral signs and emphasizes the importance of thorough oral examination to identify the threatening condition.

No MeSH data available.


Related in: MedlinePlus

Peripheral blood smear showing numerous monoblasts and promonocytes and scarcity of platelets
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Figure 2: Peripheral blood smear showing numerous monoblasts and promonocytes and scarcity of platelets

Mentions: Complete blood count was performed, and it revealed features of leukocytosis, anemia and thrombocytopenia [Table 1]. Peripheral blood smear reveals numerous monoblasts (60%) and promonocytes. Monoblasts are having moderate to severe basophilic cytoplasm with large, round nuclei and lacy chromatin. Scarcity of platelets can be appreciated with a nucleated red blood cell (RBC) in the background [Figure 2]. Based on the blood parameters and peripheral blood smear, a final diagnosis of gingival enlargement due to acute myeloid leukemia (AML) was made. The patient was advised to maintain proper oral hygiene by use of soft bristle toothbrush and 0.2% oral chlorhexidine rinses. The patient was referred to oncology center for bone marrow aspiration and chemotherapy. However, the patient could not respond to the treatment and died 4 days later due to multi organ failure.


Leukemic gingival enlargement: Report of a rare case with review of literature.

Hasan S, Khan NI, Reddy LB - Int J Appl Basic Med Res (2015 Jan-Apr)

Peripheral blood smear showing numerous monoblasts and promonocytes and scarcity of platelets
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318106&req=5

Figure 2: Peripheral blood smear showing numerous monoblasts and promonocytes and scarcity of platelets
Mentions: Complete blood count was performed, and it revealed features of leukocytosis, anemia and thrombocytopenia [Table 1]. Peripheral blood smear reveals numerous monoblasts (60%) and promonocytes. Monoblasts are having moderate to severe basophilic cytoplasm with large, round nuclei and lacy chromatin. Scarcity of platelets can be appreciated with a nucleated red blood cell (RBC) in the background [Figure 2]. Based on the blood parameters and peripheral blood smear, a final diagnosis of gingival enlargement due to acute myeloid leukemia (AML) was made. The patient was advised to maintain proper oral hygiene by use of soft bristle toothbrush and 0.2% oral chlorhexidine rinses. The patient was referred to oncology center for bone marrow aspiration and chemotherapy. However, the patient could not respond to the treatment and died 4 days later due to multi organ failure.

Bottom Line: Although gingival changes may be related to local factors in the oral cavity, it can also be an expression of systemic conditions such as blood dyscrasias, endocrinal imbalance, and nutritional deficiencies.Oral changes may be the first and only presenting signs in leukemic patients.This paper aims to throw light on an interesting case of acute leukemia diagnosed on the basis of oral signs and emphasizes the importance of thorough oral examination to identify the threatening condition.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, Okhla, New Delhi, India.

ABSTRACT
Oral cavity functions as an early indicator for a variety of systemic diseases. Early and accurate diagnosis of these underlying systemic disorders entails thorough examination of the oral mucosa, gingiva, teeth, tongue and other oral tissues. Although gingival changes may be related to local factors in the oral cavity, it can also be an expression of systemic conditions such as blood dyscrasias, endocrinal imbalance, and nutritional deficiencies. Leukemia, a malignancy of white blood cells is a dreadful disease, which, if not diagnosed properly and treated early may result in significant morbidity and mortality. Oral changes may be the first and only presenting signs in leukemic patients. This paper aims to throw light on an interesting case of acute leukemia diagnosed on the basis of oral signs and emphasizes the importance of thorough oral examination to identify the threatening condition.

No MeSH data available.


Related in: MedlinePlus