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Improvement in nutrient handling in STZ induced diabetic rats treated with Ocimum gratissimum.

Okon UA, Davies KG, Olubobokun TH - Int J Appl Basic Med Res (2015 Jan-Apr)

Bottom Line: Fecal glucose was significantly (P < 0.001) lower in the DM group compared to the control and DMT groups, with the DMT groups significantly (P < 0.001) lower than the control.Fecal cholesterol was significantly (P < 0.001) higher in the DM than the DMT and control groups with DMT significantly (P < 0.01) higher than the control.This result indicates the propensity of OG to reverse impairment of nutrient digestion and absorption in DM.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo, Akwa Ibom State, Nigeria.

ABSTRACT

Objective: Alteration in digestive and absorptive enzymatic activities has been reported in diabetes mellitus (DM), but not with Ocimum gratissimum (OG) treatment. This study was, therefore, designed to indirectly assess the effect of DM and treatment with OG on nutrient digestion and absorption, through estimation of their fecal excretion.

Materials and methods: Animals were randomly assigned into three groups of six per group for control, DM and diabetic mellitus treated (DMT). Diabetes was induced by single intraperitoneal injection of 65 mg/kg streptozotocin in the test groups. OG was administered to the DMT group at dose of 1500 mg/kg once daily for 28 days. Fecal glucose, protein and cholesterol were determined.

Results: Fecal glucose was significantly (P < 0.001) lower in the DM group compared to the control and DMT groups, with the DMT groups significantly (P < 0.001) lower than the control. Fecal protein was significantly (P < 0.001) lower in the DM group than the control whereas it was significantly lower in the DMT groups than the DM. Fecal cholesterol was significantly (P < 0.001) higher in the DM than the DMT and control groups with DMT significantly (P < 0.01) higher than the control.

Conclusion: This result indicates the propensity of OG to reverse impairment of nutrient digestion and absorption in DM.

No MeSH data available.


Related in: MedlinePlus

Comparison of fecal glucose level in the different experimental groups n = 6. ***P < 0.001 versus control, c = P < 0.001 versus diabetes mellitus
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Figure 1: Comparison of fecal glucose level in the different experimental groups n = 6. ***P < 0.001 versus control, c = P < 0.001 versus diabetes mellitus

Mentions: The mean values were: 0.68 ± 0.018, 0.356 ± 0.021 and 0.505 ± 0.013 mmol/L in control, DM and DMT groups, respectively. The DM values was significantly lower (P < 0.001) than the control and the DMT groups, with the DMT significantly (P < 0.001) lower than the control as shown in Figure 1.


Improvement in nutrient handling in STZ induced diabetic rats treated with Ocimum gratissimum.

Okon UA, Davies KG, Olubobokun TH - Int J Appl Basic Med Res (2015 Jan-Apr)

Comparison of fecal glucose level in the different experimental groups n = 6. ***P < 0.001 versus control, c = P < 0.001 versus diabetes mellitus
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318102&req=5

Figure 1: Comparison of fecal glucose level in the different experimental groups n = 6. ***P < 0.001 versus control, c = P < 0.001 versus diabetes mellitus
Mentions: The mean values were: 0.68 ± 0.018, 0.356 ± 0.021 and 0.505 ± 0.013 mmol/L in control, DM and DMT groups, respectively. The DM values was significantly lower (P < 0.001) than the control and the DMT groups, with the DMT significantly (P < 0.001) lower than the control as shown in Figure 1.

Bottom Line: Fecal glucose was significantly (P < 0.001) lower in the DM group compared to the control and DMT groups, with the DMT groups significantly (P < 0.001) lower than the control.Fecal cholesterol was significantly (P < 0.001) higher in the DM than the DMT and control groups with DMT significantly (P < 0.01) higher than the control.This result indicates the propensity of OG to reverse impairment of nutrient digestion and absorption in DM.

View Article: PubMed Central - PubMed

Affiliation: Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Uyo, Uyo, Akwa Ibom State, Nigeria.

ABSTRACT

Objective: Alteration in digestive and absorptive enzymatic activities has been reported in diabetes mellitus (DM), but not with Ocimum gratissimum (OG) treatment. This study was, therefore, designed to indirectly assess the effect of DM and treatment with OG on nutrient digestion and absorption, through estimation of their fecal excretion.

Materials and methods: Animals were randomly assigned into three groups of six per group for control, DM and diabetic mellitus treated (DMT). Diabetes was induced by single intraperitoneal injection of 65 mg/kg streptozotocin in the test groups. OG was administered to the DMT group at dose of 1500 mg/kg once daily for 28 days. Fecal glucose, protein and cholesterol were determined.

Results: Fecal glucose was significantly (P < 0.001) lower in the DM group compared to the control and DMT groups, with the DMT groups significantly (P < 0.001) lower than the control. Fecal protein was significantly (P < 0.001) lower in the DM group than the control whereas it was significantly lower in the DMT groups than the DM. Fecal cholesterol was significantly (P < 0.001) higher in the DM than the DMT and control groups with DMT significantly (P < 0.01) higher than the control.

Conclusion: This result indicates the propensity of OG to reverse impairment of nutrient digestion and absorption in DM.

No MeSH data available.


Related in: MedlinePlus