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Vitiligo delimiting dermatophyte infection.

Parimalam K, Dinesh DK, Thomas J - Indian J Dermatol (2015 Jan-Feb)

View Article: PubMed Central - PubMed

Affiliation: Prof and Head, Department of Dermatology, Villupuram Medical College, Villupuram, Tamil Nadu, India.

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Sir, Dermatophyte infection, a common superficial fungal disease is precipitated by many factors such as advanced age, collagen vascular disease, systemic corticosteroid therapy or Cushing's disease, hematologic malignancy, chronic mucocutaneous candidiasis, diabetes mellitus, atopy, underlying peripheral vascular disease, and disorders of keratinization... Langerhans cells can act as antigen-presenting cells for dermatophyte antigens... Vitiligo is documented to be associated with many autoimmune diseases... There is enough evidence that epidermal dendritic cells (Langerhans cells and intermediate cells) are absent in patients with vitiligo... The epidermal cells derived from vitiliginous skin, show a lower stimulatory effect in the allogeneic mixed skin cell lymphocyte culture reaction than those from normal skin suggesting a possibility of functional impairment of Langerhans cells in vitiliginous skin... A 70-year-old hypothyroid, diabetic woman presented with huge patch of vitiligo over the trunk which showed erythematous scaly plaque that was strictly limited to the depigmented patch... She responded well to clotrimazole cream and griseofulvin... Psoriasis and lichen planus have been reported to occur over vitiligo patch... Absence of melanin may play a role in inflammatory reactions following sun exposure according to Baghestani et al., who have reported familial colocalization of lichen planus and vitiligo on sun-exposed areas where lichen planus began from depigmented areas and then extended to normal skin... The altered expression of antigens identified by infiltrating T-cells due to photo damage over a vitiliginous patch, has been suggested as a factor in colocalization of lichen planus and vitiligo... Chhabra et al., have described pleomorphic cutaneous sarcoidosis confined to lesions of vitiligo vulgaris... The occurrence of dermatophyte infection limiting to the vitiliginous patch may be due to the local immune defect either directly to reduced or absent melanocyte or indirectly to the reduced number of Langerhans cells in a vitiligo patch.

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Related in: MedlinePlus

Same patient showing tinea corporis delimited by vitiligo over the back
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Figure 2: Same patient showing tinea corporis delimited by vitiligo over the back

Mentions: We report a female in whom tinea corporis was limited to the patch of vitiligo. A 70-year-old hypothyroid, diabetic woman presented with huge patch of vitiligo over the trunk which showed erythematous scaly plaque that was strictly limited to the depigmented patch. There was no sign of scaling over the pigmented skin [Figures 1 and 2]. Scraping for fungus was positive over the depigmented skin. All the three consecutive specimens from the pigmented, normal-appearing skin close to the scaly margin and culture on Sabouraud dextrose phosphate (SDP) agar were negative. She responded well to clotrimazole cream and griseofulvin.


Vitiligo delimiting dermatophyte infection.

Parimalam K, Dinesh DK, Thomas J - Indian J Dermatol (2015 Jan-Feb)

Same patient showing tinea corporis delimited by vitiligo over the back
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318075&req=5

Figure 2: Same patient showing tinea corporis delimited by vitiligo over the back
Mentions: We report a female in whom tinea corporis was limited to the patch of vitiligo. A 70-year-old hypothyroid, diabetic woman presented with huge patch of vitiligo over the trunk which showed erythematous scaly plaque that was strictly limited to the depigmented patch. There was no sign of scaling over the pigmented skin [Figures 1 and 2]. Scraping for fungus was positive over the depigmented skin. All the three consecutive specimens from the pigmented, normal-appearing skin close to the scaly margin and culture on Sabouraud dextrose phosphate (SDP) agar were negative. She responded well to clotrimazole cream and griseofulvin.

View Article: PubMed Central - PubMed

Affiliation: Prof and Head, Department of Dermatology, Villupuram Medical College, Villupuram, Tamil Nadu, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Dermatophyte infection, a common superficial fungal disease is precipitated by many factors such as advanced age, collagen vascular disease, systemic corticosteroid therapy or Cushing's disease, hematologic malignancy, chronic mucocutaneous candidiasis, diabetes mellitus, atopy, underlying peripheral vascular disease, and disorders of keratinization... Langerhans cells can act as antigen-presenting cells for dermatophyte antigens... Vitiligo is documented to be associated with many autoimmune diseases... There is enough evidence that epidermal dendritic cells (Langerhans cells and intermediate cells) are absent in patients with vitiligo... The epidermal cells derived from vitiliginous skin, show a lower stimulatory effect in the allogeneic mixed skin cell lymphocyte culture reaction than those from normal skin suggesting a possibility of functional impairment of Langerhans cells in vitiliginous skin... A 70-year-old hypothyroid, diabetic woman presented with huge patch of vitiligo over the trunk which showed erythematous scaly plaque that was strictly limited to the depigmented patch... She responded well to clotrimazole cream and griseofulvin... Psoriasis and lichen planus have been reported to occur over vitiligo patch... Absence of melanin may play a role in inflammatory reactions following sun exposure according to Baghestani et al., who have reported familial colocalization of lichen planus and vitiligo on sun-exposed areas where lichen planus began from depigmented areas and then extended to normal skin... The altered expression of antigens identified by infiltrating T-cells due to photo damage over a vitiliginous patch, has been suggested as a factor in colocalization of lichen planus and vitiligo... Chhabra et al., have described pleomorphic cutaneous sarcoidosis confined to lesions of vitiligo vulgaris... The occurrence of dermatophyte infection limiting to the vitiliginous patch may be due to the local immune defect either directly to reduced or absent melanocyte or indirectly to the reduced number of Langerhans cells in a vitiligo patch.

No MeSH data available.


Related in: MedlinePlus