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Atypical post kala azar dermal leishmaniasis with "muzzle area" swelling.

Arora S, Bal AS, Baveja S, Sood A, Rathi KR, Patil P - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: A 50-year-old male presented with recurrent swelling of the muzzle area of the face with history of low-grade intermittent fever of 3 year duration managed variously with antibiotics, systemic steroids, and antituberculous therapy.Immunochromatography test for rK 39 antigen and polymerase chain reaction for leishmania was positive.He was diagnosed as a case of post kala azar dermal leishmaniasis, managed with injection sodium stibogluconate and followed-up thereafter.

View Article: PubMed Central - PubMed

Affiliation: Department of Skin, Army College of Medical Sciences and Base Hospital, Cantt, New Delhi, India.

ABSTRACT
A 50-year-old male presented with recurrent swelling of the muzzle area of the face with history of low-grade intermittent fever of 3 year duration managed variously with antibiotics, systemic steroids, and antituberculous therapy. Skin biopsy revealed a granulomatous infiltration negative for acid-fast bacilli and leishmania donovan bodies. Immunochromatography test for rK 39 antigen and polymerase chain reaction for leishmania was positive. He was diagnosed as a case of post kala azar dermal leishmaniasis, managed with injection sodium stibogluconate and followed-up thereafter.

No MeSH data available.


Related in: MedlinePlus

Photomicrograph revealing granulomatous infiltration (H and E, ×10) (left) and (H and E, ×40) right
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Figure 2: Photomicrograph revealing granulomatous infiltration (H and E, ×10) (left) and (H and E, ×40) right

Mentions: Investigations revealed a normal hemogram and biochemical profile. X-ray chest and ultrasound scan abdomen did not reveal any abnormality. Enzyme-linked immunosorbent assay for human immunodeficiency virus infection was negative. Skin biopsy revealed a granulomatous infiltration negative for acid-fast bacilli as well as leishmania donovan bodies [Figure 2]. Immunochromatography test for rK39 was persistently positive. Polymerase chain reaction (PCR) for leishmania from the tissue sample was also positive. He was diagnosed as a case of PKDL, based on his clinical profile, skin histopathology of a granulomatous infiltration, positive rK39, and a positive PCR for leishmania.


Atypical post kala azar dermal leishmaniasis with "muzzle area" swelling.

Arora S, Bal AS, Baveja S, Sood A, Rathi KR, Patil P - Indian J Dermatol (2015 Jan-Feb)

Photomicrograph revealing granulomatous infiltration (H and E, ×10) (left) and (H and E, ×40) right
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318072&req=5

Figure 2: Photomicrograph revealing granulomatous infiltration (H and E, ×10) (left) and (H and E, ×40) right
Mentions: Investigations revealed a normal hemogram and biochemical profile. X-ray chest and ultrasound scan abdomen did not reveal any abnormality. Enzyme-linked immunosorbent assay for human immunodeficiency virus infection was negative. Skin biopsy revealed a granulomatous infiltration negative for acid-fast bacilli as well as leishmania donovan bodies [Figure 2]. Immunochromatography test for rK39 was persistently positive. Polymerase chain reaction (PCR) for leishmania from the tissue sample was also positive. He was diagnosed as a case of PKDL, based on his clinical profile, skin histopathology of a granulomatous infiltration, positive rK39, and a positive PCR for leishmania.

Bottom Line: A 50-year-old male presented with recurrent swelling of the muzzle area of the face with history of low-grade intermittent fever of 3 year duration managed variously with antibiotics, systemic steroids, and antituberculous therapy.Immunochromatography test for rK 39 antigen and polymerase chain reaction for leishmania was positive.He was diagnosed as a case of post kala azar dermal leishmaniasis, managed with injection sodium stibogluconate and followed-up thereafter.

View Article: PubMed Central - PubMed

Affiliation: Department of Skin, Army College of Medical Sciences and Base Hospital, Cantt, New Delhi, India.

ABSTRACT
A 50-year-old male presented with recurrent swelling of the muzzle area of the face with history of low-grade intermittent fever of 3 year duration managed variously with antibiotics, systemic steroids, and antituberculous therapy. Skin biopsy revealed a granulomatous infiltration negative for acid-fast bacilli and leishmania donovan bodies. Immunochromatography test for rK 39 antigen and polymerase chain reaction for leishmania was positive. He was diagnosed as a case of post kala azar dermal leishmaniasis, managed with injection sodium stibogluconate and followed-up thereafter.

No MeSH data available.


Related in: MedlinePlus