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Paraganglioma-like dermal melanocytic tumor.

Thyvalappil A, Sudhamani B, Kizhakkethara G, Sridharan R, Kunjan R - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: It has a benign course, although a lesion of low malignant potential cannot be excluded.We describe a case of 60-year-old female who presented with three PDMT lesions on her right leg.To the best of our knowledge this is the first case reported from India.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Pariyaram Medical College, Kannur, Kerala, India.

ABSTRACT
Paraganglioma-like dermal melanocytic tumor (PDMT) is a rare subtype of benign dermal melanocytic tumor, first described in 2004. Its histopathologic features resemble those of paraganglioma, showing presence of a distinctive partitioning of the tumor into small and large packets, nests, or short cords by delicate fibrous septa (zellballen pattern). But the immunostaining characteristics are those of melanocytic lesions, as PDMT express S-100, melan A, HMB 45 and lack pancytokeratin markers. It has a benign course, although a lesion of low malignant potential cannot be excluded. We describe a case of 60-year-old female who presented with three PDMT lesions on her right leg. To the best of our knowledge this is the first case reported from India.

No MeSH data available.


Related in: MedlinePlus

Erythematous polypoidal fleshy nodules over the leg (taken after excision biopsy of one lesion)
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Figure 1: Erythematous polypoidal fleshy nodules over the leg (taken after excision biopsy of one lesion)

Mentions: A 60-year-old female presented with one year history of three asymptomatic slowly growing lesions on her right lower leg. It started as a single raised lesion near medial aspect of right ankle, which slowly increased in size. Three months later patient developed two more similar slow growing lesions nearby. On examination, patient had three linearly arranged erythematous polypoidal fleshy nodules of size ranging from 1 × 1 to 3 × 2 cm, with the larger lesion showing ulcerations and crusting on the surface [Figure 1]. Lesions were firm and nonindurated. There was no pallor or lymph node enlargement. Systemic examination did not show any abnormality.


Paraganglioma-like dermal melanocytic tumor.

Thyvalappil A, Sudhamani B, Kizhakkethara G, Sridharan R, Kunjan R - Indian J Dermatol (2015 Jan-Feb)

Erythematous polypoidal fleshy nodules over the leg (taken after excision biopsy of one lesion)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318069&req=5

Figure 1: Erythematous polypoidal fleshy nodules over the leg (taken after excision biopsy of one lesion)
Mentions: A 60-year-old female presented with one year history of three asymptomatic slowly growing lesions on her right lower leg. It started as a single raised lesion near medial aspect of right ankle, which slowly increased in size. Three months later patient developed two more similar slow growing lesions nearby. On examination, patient had three linearly arranged erythematous polypoidal fleshy nodules of size ranging from 1 × 1 to 3 × 2 cm, with the larger lesion showing ulcerations and crusting on the surface [Figure 1]. Lesions were firm and nonindurated. There was no pallor or lymph node enlargement. Systemic examination did not show any abnormality.

Bottom Line: It has a benign course, although a lesion of low malignant potential cannot be excluded.We describe a case of 60-year-old female who presented with three PDMT lesions on her right leg.To the best of our knowledge this is the first case reported from India.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Pariyaram Medical College, Kannur, Kerala, India.

ABSTRACT
Paraganglioma-like dermal melanocytic tumor (PDMT) is a rare subtype of benign dermal melanocytic tumor, first described in 2004. Its histopathologic features resemble those of paraganglioma, showing presence of a distinctive partitioning of the tumor into small and large packets, nests, or short cords by delicate fibrous septa (zellballen pattern). But the immunostaining characteristics are those of melanocytic lesions, as PDMT express S-100, melan A, HMB 45 and lack pancytokeratin markers. It has a benign course, although a lesion of low malignant potential cannot be excluded. We describe a case of 60-year-old female who presented with three PDMT lesions on her right leg. To the best of our knowledge this is the first case reported from India.

No MeSH data available.


Related in: MedlinePlus