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Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus.

Ibrahim ZA, El Ashmawy AA, Abd El-Naby NM, Ghoraba HM - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: Elevated expression of cathepsin L has been found in many inflammatory and neoplastic diseases.Highly significant increase was found in cathepsin L expression in AD and LP patients compared to controls [P = 0.001].It could be a useful marker for assessing AD severity.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.

ABSTRACT

Background: Cathepsin L is a member of papain superfamily. It seems to promote T-cell survival, selection maturation in the thymus and enhance the antigen presentation. Cathepsin L plays an important role in tumor necrosis factors (TNF-α) induced cell death. Also it degrades the tight junction between cornedesomses in the epidermis. Elevated expression of cathepsin L has been found in many inflammatory and neoplastic diseases.

Objective: The aim of this study was to determine immunohistochemical expression of cathepsin L in atopic dermatitis (AD) and lichen planus (LP) patients in order to evaluate its role in the pathogenesis of both diseases.

Materials and methods: This study included 15 patients with AD (Group I), 15 patients with LP (Group II), in addition to 10 healthy skin specimens served as controls (Group III). Punch biopsies were taken from lesional skin of the patients and controls for immunohistochemical detection of cathepsin L expression.

Results: Highly significant increase was found in cathepsin L expression in AD and LP patients compared to controls [P = 0.001].

Conclusion: Cathepsin L could be implicated as an important protease in the pathogenesis of AD and LP. It could be a useful marker for assessing AD severity.

No MeSH data available.


Related in: MedlinePlus

(a and b) Atopic dermatitis showing acanthosis [black line] and aggregates of mononuclear cells mainly lymphocytes in the upper dermis [white arrow] mainly perivascular [black arrow] (H and E, ×100 and ×400, scale bar 10 μm)
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Figure 1: (a and b) Atopic dermatitis showing acanthosis [black line] and aggregates of mononuclear cells mainly lymphocytes in the upper dermis [white arrow] mainly perivascular [black arrow] (H and E, ×100 and ×400, scale bar 10 μm)

Mentions: The histopathologic picture of AD is characterized by hyperplasia and hyperkeratosis of the epidermis, spongiosis secondary to intracellular edema in acute lesions, and in chronic lesions, there is moderate to marked hyperplasia of the epidermis, elongation of the rete ridges and prominent hyperkeratosis and areas of parakeratosis, marked infiltrate of lymphocytes, rare monocytes and macrophages is present around the venous plexus in the dermis. [Figure 1a and b].


Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus.

Ibrahim ZA, El Ashmawy AA, Abd El-Naby NM, Ghoraba HM - Indian J Dermatol (2015 Jan-Feb)

(a and b) Atopic dermatitis showing acanthosis [black line] and aggregates of mononuclear cells mainly lymphocytes in the upper dermis [white arrow] mainly perivascular [black arrow] (H and E, ×100 and ×400, scale bar 10 μm)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318056&req=5

Figure 1: (a and b) Atopic dermatitis showing acanthosis [black line] and aggregates of mononuclear cells mainly lymphocytes in the upper dermis [white arrow] mainly perivascular [black arrow] (H and E, ×100 and ×400, scale bar 10 μm)
Mentions: The histopathologic picture of AD is characterized by hyperplasia and hyperkeratosis of the epidermis, spongiosis secondary to intracellular edema in acute lesions, and in chronic lesions, there is moderate to marked hyperplasia of the epidermis, elongation of the rete ridges and prominent hyperkeratosis and areas of parakeratosis, marked infiltrate of lymphocytes, rare monocytes and macrophages is present around the venous plexus in the dermis. [Figure 1a and b].

Bottom Line: Elevated expression of cathepsin L has been found in many inflammatory and neoplastic diseases.Highly significant increase was found in cathepsin L expression in AD and LP patients compared to controls [P = 0.001].It could be a useful marker for assessing AD severity.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.

ABSTRACT

Background: Cathepsin L is a member of papain superfamily. It seems to promote T-cell survival, selection maturation in the thymus and enhance the antigen presentation. Cathepsin L plays an important role in tumor necrosis factors (TNF-α) induced cell death. Also it degrades the tight junction between cornedesomses in the epidermis. Elevated expression of cathepsin L has been found in many inflammatory and neoplastic diseases.

Objective: The aim of this study was to determine immunohistochemical expression of cathepsin L in atopic dermatitis (AD) and lichen planus (LP) patients in order to evaluate its role in the pathogenesis of both diseases.

Materials and methods: This study included 15 patients with AD (Group I), 15 patients with LP (Group II), in addition to 10 healthy skin specimens served as controls (Group III). Punch biopsies were taken from lesional skin of the patients and controls for immunohistochemical detection of cathepsin L expression.

Results: Highly significant increase was found in cathepsin L expression in AD and LP patients compared to controls [P = 0.001].

Conclusion: Cathepsin L could be implicated as an important protease in the pathogenesis of AD and LP. It could be a useful marker for assessing AD severity.

No MeSH data available.


Related in: MedlinePlus