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Squamous cell carcinoma arising from a giant cutaneous horn: a rare presentation.

Leelavathy B, Kemparaj T, Sathish S, Khadri SI - Indian J Dermatol (2015 Jan-Feb)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Bangalore Medical College, Bangalore, Karnataka, India.

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Cutaneous horns are horny plugs or outgrowths that may be caused by various epidermal changes, such as epidermal naevus, viral wart, molluscum contagiosum, keratoacanthoma, seborrheic keratosis, marsupialized trichilemmal cyst and squamous cell carcinoma... A 62-year-old man presented to us with 6 months history of growth on the left angle of the mouth, which was insidious in onset, initially measuring the size of a pea and progressively increasing in size... There was no history of any other dermatological illness... Local examination revealed a single conical, projection measuring 7 × 3 cm in size, hard in consistency, beginning over the left side of the angle of the mouth, growing downwards and laterally up to the level of upper one-third of the neck; base of the lesion showed crusting and purulent material [Figures 1a and b]... Oral cavity did not show any lesion... Systemic examination was normal... Routine blood investigations were within normal limits... The lesion was excised and sent for histopathological examination, which showed marked hyperkeratosis, striking acanthosis, elongated bulbous rete ridges, breach in basement membrane with broad-based islands of keratinocytes invading the stroma, numerous keratin pearls seen in the dermis, minimal cytological atypia with lymphocytic infiltrate... The findings were consistent with squamous cell carcinoma of verrucous variant [Figures 2a and b]... Several cases of giant cutaneous horns have been reported... Another case of giant cutaneous horn in a young female of five year duration arising from a burn scar from right parietal region measuring 6 × 3 cm in size was reported in an African woman.

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(a) Low power view (×10) of H and E stain showing marked hyperkeratosis, striking acanthosis, elongated bulbous rete ridges, broad-based islands of keratinocytes invading the stroma, numerous keratin pearls seen in the dermis. (b) High power view (×40) of H and E stain of keratin pearl showing minimal cytological atypia
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Figure 2: (a) Low power view (×10) of H and E stain showing marked hyperkeratosis, striking acanthosis, elongated bulbous rete ridges, broad-based islands of keratinocytes invading the stroma, numerous keratin pearls seen in the dermis. (b) High power view (×40) of H and E stain of keratin pearl showing minimal cytological atypia

Mentions: Routine blood investigations were within normal limits. The lesion was excised and sent for histopathological examination, which showed marked hyperkeratosis, striking acanthosis, elongated bulbous rete ridges, breach in basement membrane with broad-based islands of keratinocytes invading the stroma, numerous keratin pearls seen in the dermis, minimal cytological atypia with lymphocytic infiltrate. The findings were consistent with squamous cell carcinoma of verrucous variant [Figures 2a and b].


Squamous cell carcinoma arising from a giant cutaneous horn: a rare presentation.

Leelavathy B, Kemparaj T, Sathish S, Khadri SI - Indian J Dermatol (2015 Jan-Feb)

(a) Low power view (×10) of H and E stain showing marked hyperkeratosis, striking acanthosis, elongated bulbous rete ridges, broad-based islands of keratinocytes invading the stroma, numerous keratin pearls seen in the dermis. (b) High power view (×40) of H and E stain of keratin pearl showing minimal cytological atypia
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318052&req=5

Figure 2: (a) Low power view (×10) of H and E stain showing marked hyperkeratosis, striking acanthosis, elongated bulbous rete ridges, broad-based islands of keratinocytes invading the stroma, numerous keratin pearls seen in the dermis. (b) High power view (×40) of H and E stain of keratin pearl showing minimal cytological atypia
Mentions: Routine blood investigations were within normal limits. The lesion was excised and sent for histopathological examination, which showed marked hyperkeratosis, striking acanthosis, elongated bulbous rete ridges, breach in basement membrane with broad-based islands of keratinocytes invading the stroma, numerous keratin pearls seen in the dermis, minimal cytological atypia with lymphocytic infiltrate. The findings were consistent with squamous cell carcinoma of verrucous variant [Figures 2a and b].

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Bangalore Medical College, Bangalore, Karnataka, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Cutaneous horns are horny plugs or outgrowths that may be caused by various epidermal changes, such as epidermal naevus, viral wart, molluscum contagiosum, keratoacanthoma, seborrheic keratosis, marsupialized trichilemmal cyst and squamous cell carcinoma... A 62-year-old man presented to us with 6 months history of growth on the left angle of the mouth, which was insidious in onset, initially measuring the size of a pea and progressively increasing in size... There was no history of any other dermatological illness... Local examination revealed a single conical, projection measuring 7 × 3 cm in size, hard in consistency, beginning over the left side of the angle of the mouth, growing downwards and laterally up to the level of upper one-third of the neck; base of the lesion showed crusting and purulent material [Figures 1a and b]... Oral cavity did not show any lesion... Systemic examination was normal... Routine blood investigations were within normal limits... The lesion was excised and sent for histopathological examination, which showed marked hyperkeratosis, striking acanthosis, elongated bulbous rete ridges, breach in basement membrane with broad-based islands of keratinocytes invading the stroma, numerous keratin pearls seen in the dermis, minimal cytological atypia with lymphocytic infiltrate... The findings were consistent with squamous cell carcinoma of verrucous variant [Figures 2a and b]... Several cases of giant cutaneous horns have been reported... Another case of giant cutaneous horn in a young female of five year duration arising from a burn scar from right parietal region measuring 6 × 3 cm in size was reported in an African woman.

No MeSH data available.


Related in: MedlinePlus