Limits...
Papular mycosis fungoides: a case report and review in the literature.

Balta I, Akbay G, Eksioglu M, Astarc─▒ M, Ekiz O - Indian J Dermatol (2015 Jan-Feb)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Ministry of Health, Kecioren Training and Research Hospital, Ankara, Turkey.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, A 35-year-old male patient presented with skin eruptions on his trunk and upper and lower extremities, which had appeared 2 years ago... The lesions were persistent and did not show any tendency for spontaneous resolution... Dermatological examination revealed a great number of slightly scaly erythematous papules on his trunk and upper and lower extremities, clustered together or scattered, and varying in sizes between 2-3 mm and 8-9 mm [Figure 1]... The same lesions can also occur at the onset of the disease without any evidence or history of preceding patches... PLEVA is frequently characterized by eruptions of pink, orange, or purpuric papules that undergo central vesiculation, may ulcerate, and resolve with hemorrhagic crusts... The etiopathogenesis of MF is not exactly known... In early stage MF lesions, T helper 1 and CD8 cells are intensively found and they control malignant clonal proliferation... In advanced stage MF, T-helper 2 cytokine such as IL-4 and IL-10 increase... CD8 cells decreases and thus neoplastic cells increase... CD8 positive staining was also determined only in one of the cases previously reported in the literature... The diagnosis of papular MF was made in our case, by the presence of only erythematous papules, by absence of patch and plaque lesions before these lesions, and upon confirmation with histopathologic and immunohistochemical methods... This case is presented in order to keep in mind papular MF, which is a new and very rare variant of early stage MF, in evaluating patients presenting with pruritic, erythematous papules.

No MeSH data available.


Erythematous papules on the left scapular region
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4318050&req=5

Figure 1: Erythematous papules on the left scapular region

Mentions: A 35-year-old male patient presented with skin eruptions on his trunk and upper and lower extremities, which had appeared 2 years ago. The lesions were persistent and did not show any tendency for spontaneous resolution. There was no history of any other dermatological disease or drug intake. Dermatological examination revealed a great number of slightly scaly erythematous papules on his trunk and upper and lower extremities, clustered together or scattered, and varying in sizes between 2-3 mm and 8-9 mm [Figure 1]. Histopathological examination revealed mild acanthosis in the epidermis and exocytosis of lymphocytes with hyperchromatic convoluted nuclei exhibiting apparent epidermotropism. There were small collections of lymphocytes (Pautrier's microabscesses) within the epidermis in some areas [Figure 2]. Immunohistochemical examination revealed CD8 positive staining in the intraepithelial focal regions; CD3 positive staining in the perivascular lymphocytes and intraepithelial focal regions; CD45RO positive staining in the perivascular lymphocytes and CD4 and CD30 negative staining. Molecular analyses of the T-cell receptor gene rearrangement showed the presence of a monoclonal band. With these findings, the patient was diagnosed with mycosis fungoides (MF) and psoralen + ultraviolet A (PUVA) treatment was started. Complete regression was achieved after 2 months. The patient had no recurrence during a period of 10 months after first diagnosis. Common patches of MF were not observed during the follow-up visit.


Papular mycosis fungoides: a case report and review in the literature.

Balta I, Akbay G, Eksioglu M, Astarc─▒ M, Ekiz O - Indian J Dermatol (2015 Jan-Feb)

Erythematous papules on the left scapular region
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318050&req=5

Figure 1: Erythematous papules on the left scapular region
Mentions: A 35-year-old male patient presented with skin eruptions on his trunk and upper and lower extremities, which had appeared 2 years ago. The lesions were persistent and did not show any tendency for spontaneous resolution. There was no history of any other dermatological disease or drug intake. Dermatological examination revealed a great number of slightly scaly erythematous papules on his trunk and upper and lower extremities, clustered together or scattered, and varying in sizes between 2-3 mm and 8-9 mm [Figure 1]. Histopathological examination revealed mild acanthosis in the epidermis and exocytosis of lymphocytes with hyperchromatic convoluted nuclei exhibiting apparent epidermotropism. There were small collections of lymphocytes (Pautrier's microabscesses) within the epidermis in some areas [Figure 2]. Immunohistochemical examination revealed CD8 positive staining in the intraepithelial focal regions; CD3 positive staining in the perivascular lymphocytes and intraepithelial focal regions; CD45RO positive staining in the perivascular lymphocytes and CD4 and CD30 negative staining. Molecular analyses of the T-cell receptor gene rearrangement showed the presence of a monoclonal band. With these findings, the patient was diagnosed with mycosis fungoides (MF) and psoralen + ultraviolet A (PUVA) treatment was started. Complete regression was achieved after 2 months. The patient had no recurrence during a period of 10 months after first diagnosis. Common patches of MF were not observed during the follow-up visit.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Ministry of Health, Kecioren Training and Research Hospital, Ankara, Turkey.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, A 35-year-old male patient presented with skin eruptions on his trunk and upper and lower extremities, which had appeared 2 years ago... The lesions were persistent and did not show any tendency for spontaneous resolution... Dermatological examination revealed a great number of slightly scaly erythematous papules on his trunk and upper and lower extremities, clustered together or scattered, and varying in sizes between 2-3 mm and 8-9 mm [Figure 1]... The same lesions can also occur at the onset of the disease without any evidence or history of preceding patches... PLEVA is frequently characterized by eruptions of pink, orange, or purpuric papules that undergo central vesiculation, may ulcerate, and resolve with hemorrhagic crusts... The etiopathogenesis of MF is not exactly known... In early stage MF lesions, T helper 1 and CD8 cells are intensively found and they control malignant clonal proliferation... In advanced stage MF, T-helper 2 cytokine such as IL-4 and IL-10 increase... CD8 cells decreases and thus neoplastic cells increase... CD8 positive staining was also determined only in one of the cases previously reported in the literature... The diagnosis of papular MF was made in our case, by the presence of only erythematous papules, by absence of patch and plaque lesions before these lesions, and upon confirmation with histopathologic and immunohistochemical methods... This case is presented in order to keep in mind papular MF, which is a new and very rare variant of early stage MF, in evaluating patients presenting with pruritic, erythematous papules.

No MeSH data available.