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Unusual presentation of atrichia with papular lesions.

Robati RM, Posh FB, Sakoei S, Ranjbar M - Indian J Dermatol (2015 Jan-Feb)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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Sir, Atrichia with papular lesions (APL) is a rare form of total alopecia followed by eruptions of papular lesions on the skin... Patients with this form of alopecia show normal hairs at birth but hair loss occurred soon after birth... Papules extended to her trunk and arms gradually [Figure 2]... She revealed no history of hyperhidrosis, decrease in vision, hearing loss or seizure... Her palms and soles were also normal... She did not have any systemic involvement or dysmorphic features... Based on the clinical and pathological findings a diagnosis of APL was made... APL is an autosomal recessive inheritance disease with irreversible alopecia of the scalp and body associated by development of papular lesions of keratin cysts over of the body... APL is frequently misdiagnosed as alopecia universalis... This may be due to several factors such as the rarity of the diseases and the lack of specific criteria for diagnosis... In our patient, the papular lesions showed an adult onset in contrast to the other studies that indicated a childhood onset... In presenting case, the papular lesions was mistakenly diagnosed and treated as genital wart for a long period of time... Therefore, it would better to keep in mind the diagnosis of atrichia with papular lesion in adult patients with generalized alopecia to avoid wrong diagnosis such as viral wart.

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Multiple mid-dermal keratin cysts with granular layer and laminated keratin in the mid-dermis with sparse peri-follicular lymphocytic infiltrate (H and E, ×40)
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Figure 3: Multiple mid-dermal keratin cysts with granular layer and laminated keratin in the mid-dermis with sparse peri-follicular lymphocytic infiltrate (H and E, ×40)

Mentions: The skin biopsy from a papule on the elbow revealed multiple mid-dermal keratin cysts with granular layer and laminated keratin in the mid-dermis with sparse peri-follicular lymphocytic infiltrate [Figure 3]. Based on the clinical and pathological findings a diagnosis of APL was made.


Unusual presentation of atrichia with papular lesions.

Robati RM, Posh FB, Sakoei S, Ranjbar M - Indian J Dermatol (2015 Jan-Feb)

Multiple mid-dermal keratin cysts with granular layer and laminated keratin in the mid-dermis with sparse peri-follicular lymphocytic infiltrate (H and E, ×40)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318049&req=5

Figure 3: Multiple mid-dermal keratin cysts with granular layer and laminated keratin in the mid-dermis with sparse peri-follicular lymphocytic infiltrate (H and E, ×40)
Mentions: The skin biopsy from a papule on the elbow revealed multiple mid-dermal keratin cysts with granular layer and laminated keratin in the mid-dermis with sparse peri-follicular lymphocytic infiltrate [Figure 3]. Based on the clinical and pathological findings a diagnosis of APL was made.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, Atrichia with papular lesions (APL) is a rare form of total alopecia followed by eruptions of papular lesions on the skin... Patients with this form of alopecia show normal hairs at birth but hair loss occurred soon after birth... Papules extended to her trunk and arms gradually [Figure 2]... She revealed no history of hyperhidrosis, decrease in vision, hearing loss or seizure... Her palms and soles were also normal... She did not have any systemic involvement or dysmorphic features... Based on the clinical and pathological findings a diagnosis of APL was made... APL is an autosomal recessive inheritance disease with irreversible alopecia of the scalp and body associated by development of papular lesions of keratin cysts over of the body... APL is frequently misdiagnosed as alopecia universalis... This may be due to several factors such as the rarity of the diseases and the lack of specific criteria for diagnosis... In our patient, the papular lesions showed an adult onset in contrast to the other studies that indicated a childhood onset... In presenting case, the papular lesions was mistakenly diagnosed and treated as genital wart for a long period of time... Therefore, it would better to keep in mind the diagnosis of atrichia with papular lesion in adult patients with generalized alopecia to avoid wrong diagnosis such as viral wart.

No MeSH data available.


Related in: MedlinePlus