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Immune reconstitution inflammatory syndrome unmasking erythema nodosum leprosum: a rare case report.

Arakkal GK, Damarla SV, Chanda GM - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: Immune reconstitution inflammatory syndrome (IRIS) occurs as an acute symptomatic expression of a latent infection during the recovery of immune system in response to antiretroviral therapy in HIV patients.IRIS triggers both opportunistic and non-opportunistic infections.We report a case of IRIS in a patient with HIV, presenting as erythema nodosum leprosum (ENL), which led to unmasking of lepromatous leprosy following anti-retroviral therapy (ART).

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Venereology and Leprosy, Gandhi Medical College, Secunderabad, Andhra Pradesh, India.

ABSTRACT
Immune reconstitution inflammatory syndrome (IRIS) occurs as an acute symptomatic expression of a latent infection during the recovery of immune system in response to antiretroviral therapy in HIV patients. IRIS triggers both opportunistic and non-opportunistic infections. We report a case of IRIS in a patient with HIV, presenting as erythema nodosum leprosum (ENL), which led to unmasking of lepromatous leprosy following anti-retroviral therapy (ART).

No MeSH data available.


Related in: MedlinePlus

Multiple erythematous papules and nodules (ENL lesions) over face (a) and forehead (b)
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Figure 2: Multiple erythematous papules and nodules (ENL lesions) over face (a) and forehead (b)

Mentions: On general examination, he was pale, thin built, ill nourished and febrile. On examination, there was no generalized lymphadenopathy. There was diffuse infiltration of ear lobe [Figure 1]. Multiple erythematous, tender papules, and nodules were present on the face [Figure 2] and also on trunk and extremities [Figure 3]. Sensations of pain and touch were reduced over both the feet. Ulnar, radial cutaneous, lateral popliteal, and posterior tibial nerves on both sides were thickened and tender. Hair, nails and mucous membranes were normal. Systemic Examination revealed no abnormalities.


Immune reconstitution inflammatory syndrome unmasking erythema nodosum leprosum: a rare case report.

Arakkal GK, Damarla SV, Chanda GM - Indian J Dermatol (2015 Jan-Feb)

Multiple erythematous papules and nodules (ENL lesions) over face (a) and forehead (b)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318046&req=5

Figure 2: Multiple erythematous papules and nodules (ENL lesions) over face (a) and forehead (b)
Mentions: On general examination, he was pale, thin built, ill nourished and febrile. On examination, there was no generalized lymphadenopathy. There was diffuse infiltration of ear lobe [Figure 1]. Multiple erythematous, tender papules, and nodules were present on the face [Figure 2] and also on trunk and extremities [Figure 3]. Sensations of pain and touch were reduced over both the feet. Ulnar, radial cutaneous, lateral popliteal, and posterior tibial nerves on both sides were thickened and tender. Hair, nails and mucous membranes were normal. Systemic Examination revealed no abnormalities.

Bottom Line: Immune reconstitution inflammatory syndrome (IRIS) occurs as an acute symptomatic expression of a latent infection during the recovery of immune system in response to antiretroviral therapy in HIV patients.IRIS triggers both opportunistic and non-opportunistic infections.We report a case of IRIS in a patient with HIV, presenting as erythema nodosum leprosum (ENL), which led to unmasking of lepromatous leprosy following anti-retroviral therapy (ART).

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Venereology and Leprosy, Gandhi Medical College, Secunderabad, Andhra Pradesh, India.

ABSTRACT
Immune reconstitution inflammatory syndrome (IRIS) occurs as an acute symptomatic expression of a latent infection during the recovery of immune system in response to antiretroviral therapy in HIV patients. IRIS triggers both opportunistic and non-opportunistic infections. We report a case of IRIS in a patient with HIV, presenting as erythema nodosum leprosum (ENL), which led to unmasking of lepromatous leprosy following anti-retroviral therapy (ART).

No MeSH data available.


Related in: MedlinePlus