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Extra Mammary Paget's Disease: A Rare Case Report.

Sardesai VR, Agarwal TD, Sakhalkar SP - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which progressed gradually over 3 years and did not respond to any topical/systemic steroids, antibiotics, and antifungals.Biopsy showed Paget's cells which were positive for Periodic Acid Schiff and alcian blue stain.Surgical excision was done considering the premalignant potential.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, STD and Leprosy, Bharati Vidyapeeth Medical College, Pune, India.

ABSTRACT
Extramammary Paget's disease is a marginated plaque resembling Paget's disease but occurring in anogenital area, axilla or most commonly on the vulva. A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which progressed gradually over 3 years and did not respond to any topical/systemic steroids, antibiotics, and antifungals. Examination revealed 7 × 8 cm. hypertrophic, verrucous plaque with erosions, and crusts at places. There was no evidence of visceral malignancy. Biopsy showed Paget's cells which were positive for Periodic Acid Schiff and alcian blue stain. Surgical excision was done considering the premalignant potential.

No MeSH data available.


Related in: MedlinePlus

Paget's cells in PAS stain ×40
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Figure 4: Paget's cells in PAS stain ×40

Mentions: A part of the plaque was excised for histopathological evaluation. Hematoxylin and eosin staining of the biopsy from the lesion showed large round cells with ample pale-staining cytoplasm, pleomorphic nuclei, and occasional prominent nucleoli, indicative of Paget cells. Inflammatory infiltrate with invasion of Paget's cells into the dermis at places was seen [Figure 3]. Cells were positive for PAS lying singly and in clusters also seen infiltrating along the skin appendages [Figure 4].


Extra Mammary Paget's Disease: A Rare Case Report.

Sardesai VR, Agarwal TD, Sakhalkar SP - Indian J Dermatol (2015 Jan-Feb)

Paget's cells in PAS stain ×40
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318038&req=5

Figure 4: Paget's cells in PAS stain ×40
Mentions: A part of the plaque was excised for histopathological evaluation. Hematoxylin and eosin staining of the biopsy from the lesion showed large round cells with ample pale-staining cytoplasm, pleomorphic nuclei, and occasional prominent nucleoli, indicative of Paget cells. Inflammatory infiltrate with invasion of Paget's cells into the dermis at places was seen [Figure 3]. Cells were positive for PAS lying singly and in clusters also seen infiltrating along the skin appendages [Figure 4].

Bottom Line: A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which progressed gradually over 3 years and did not respond to any topical/systemic steroids, antibiotics, and antifungals.Biopsy showed Paget's cells which were positive for Periodic Acid Schiff and alcian blue stain.Surgical excision was done considering the premalignant potential.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, STD and Leprosy, Bharati Vidyapeeth Medical College, Pune, India.

ABSTRACT
Extramammary Paget's disease is a marginated plaque resembling Paget's disease but occurring in anogenital area, axilla or most commonly on the vulva. A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which progressed gradually over 3 years and did not respond to any topical/systemic steroids, antibiotics, and antifungals. Examination revealed 7 × 8 cm. hypertrophic, verrucous plaque with erosions, and crusts at places. There was no evidence of visceral malignancy. Biopsy showed Paget's cells which were positive for Periodic Acid Schiff and alcian blue stain. Surgical excision was done considering the premalignant potential.

No MeSH data available.


Related in: MedlinePlus