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Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations.

Suranagi VV, Siddramappa B, Bannur HB, Patil PV, Davangeri RS - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions.Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence.We report a case with a rare combination of biphasic, bullous variant of familial LA.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, J N Medical College, Belgaum, Karnataka, India.

ABSTRACT
A 55-year-old man presented with multiple, itchy papules and macules on the trunk and extremities. Histopathologic examination of biopsy specimens taken from three different lesions showed a subepidermal blister with amyloid deposits in the dermal papillae. No systemic disease or involvement of other organs was detected. The clinical and histological findings were compatible with a bullous variant of lichen amyloidosis (LA). Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions. Bullous lesions associated with LA are very rare. Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence. We report a case with a rare combination of biphasic, bullous variant of familial LA.

No MeSH data available.


Related in: MedlinePlus

(a and b) Subepidermal blister with deposits of eosinophilic, homogenous amyloid (arrows) in the dermal papillae (H and E, ×100). (c) Amyloid in dermal papilla (Congo red stain, ×400)
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Figure 3: (a and b) Subepidermal blister with deposits of eosinophilic, homogenous amyloid (arrows) in the dermal papillae (H and E, ×100). (c) Amyloid in dermal papilla (Congo red stain, ×400)

Mentions: Histopathologic examination of skin biopsy specimens showed a subepidermal blister with irregular acanthosis and hyperkeratosis of the overlying epidermis. A few eosinophils were found in the blister. Deposits of eosinophilic, homogenous amyloid were visible in the dermal papillae, which were confirmed on Congo red staining. The deposits were not seen around blood vessels or adnexal structures [Figure 3].


Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations.

Suranagi VV, Siddramappa B, Bannur HB, Patil PV, Davangeri RS - Indian J Dermatol (2015 Jan-Feb)

(a and b) Subepidermal blister with deposits of eosinophilic, homogenous amyloid (arrows) in the dermal papillae (H and E, ×100). (c) Amyloid in dermal papilla (Congo red stain, ×400)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318037&req=5

Figure 3: (a and b) Subepidermal blister with deposits of eosinophilic, homogenous amyloid (arrows) in the dermal papillae (H and E, ×100). (c) Amyloid in dermal papilla (Congo red stain, ×400)
Mentions: Histopathologic examination of skin biopsy specimens showed a subepidermal blister with irregular acanthosis and hyperkeratosis of the overlying epidermis. A few eosinophils were found in the blister. Deposits of eosinophilic, homogenous amyloid were visible in the dermal papillae, which were confirmed on Congo red staining. The deposits were not seen around blood vessels or adnexal structures [Figure 3].

Bottom Line: Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions.Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence.We report a case with a rare combination of biphasic, bullous variant of familial LA.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, J N Medical College, Belgaum, Karnataka, India.

ABSTRACT
A 55-year-old man presented with multiple, itchy papules and macules on the trunk and extremities. Histopathologic examination of biopsy specimens taken from three different lesions showed a subepidermal blister with amyloid deposits in the dermal papillae. No systemic disease or involvement of other organs was detected. The clinical and histological findings were compatible with a bullous variant of lichen amyloidosis (LA). Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions. Bullous lesions associated with LA are very rare. Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence. We report a case with a rare combination of biphasic, bullous variant of familial LA.

No MeSH data available.


Related in: MedlinePlus