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Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations.

Suranagi VV, Siddramappa B, Bannur HB, Patil PV, Davangeri RS - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions.Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence.We report a case with a rare combination of biphasic, bullous variant of familial LA.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, J N Medical College, Belgaum, Karnataka, India.

ABSTRACT
A 55-year-old man presented with multiple, itchy papules and macules on the trunk and extremities. Histopathologic examination of biopsy specimens taken from three different lesions showed a subepidermal blister with amyloid deposits in the dermal papillae. No systemic disease or involvement of other organs was detected. The clinical and histological findings were compatible with a bullous variant of lichen amyloidosis (LA). Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions. Bullous lesions associated with LA are very rare. Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence. We report a case with a rare combination of biphasic, bullous variant of familial LA.

No MeSH data available.


Related in: MedlinePlus

Pedigree chart: Eight members of the same family were affected. Blue square-male affected, blue circle-female affected, white circle-female unaffected, M: Mother, F: Father, Pt: Patient
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Figure 2: Pedigree chart: Eight members of the same family were affected. Blue square-male affected, blue circle-female affected, white circle-female unaffected, M: Mother, F: Father, Pt: Patient

Mentions: A strong family history was obtained. Both of his parents, one sister, two brothers and two of his father's brothers had a history of similar lesions. Eight members of the same family were affected [Figure 2].


Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations.

Suranagi VV, Siddramappa B, Bannur HB, Patil PV, Davangeri RS - Indian J Dermatol (2015 Jan-Feb)

Pedigree chart: Eight members of the same family were affected. Blue square-male affected, blue circle-female affected, white circle-female unaffected, M: Mother, F: Father, Pt: Patient
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318037&req=5

Figure 2: Pedigree chart: Eight members of the same family were affected. Blue square-male affected, blue circle-female affected, white circle-female unaffected, M: Mother, F: Father, Pt: Patient
Mentions: A strong family history was obtained. Both of his parents, one sister, two brothers and two of his father's brothers had a history of similar lesions. Eight members of the same family were affected [Figure 2].

Bottom Line: Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions.Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence.We report a case with a rare combination of biphasic, bullous variant of familial LA.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, J N Medical College, Belgaum, Karnataka, India.

ABSTRACT
A 55-year-old man presented with multiple, itchy papules and macules on the trunk and extremities. Histopathologic examination of biopsy specimens taken from three different lesions showed a subepidermal blister with amyloid deposits in the dermal papillae. No systemic disease or involvement of other organs was detected. The clinical and histological findings were compatible with a bullous variant of lichen amyloidosis (LA). Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions. Bullous lesions associated with LA are very rare. Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence. We report a case with a rare combination of biphasic, bullous variant of familial LA.

No MeSH data available.


Related in: MedlinePlus