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Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations.

Suranagi VV, Siddramappa B, Bannur HB, Patil PV, Davangeri RS - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions.Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence.We report a case with a rare combination of biphasic, bullous variant of familial LA.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, J N Medical College, Belgaum, Karnataka, India.

ABSTRACT
A 55-year-old man presented with multiple, itchy papules and macules on the trunk and extremities. Histopathologic examination of biopsy specimens taken from three different lesions showed a subepidermal blister with amyloid deposits in the dermal papillae. No systemic disease or involvement of other organs was detected. The clinical and histological findings were compatible with a bullous variant of lichen amyloidosis (LA). Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions. Bullous lesions associated with LA are very rare. Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence. We report a case with a rare combination of biphasic, bullous variant of familial LA.

No MeSH data available.


Related in: MedlinePlus

(a) Multiple, discrete, waxy papules on an erythematous base on the leg, with few vesicles. (b) Irregular, reddish-brown, lace-like macules on the arm
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Figure 1: (a) Multiple, discrete, waxy papules on an erythematous base on the leg, with few vesicles. (b) Irregular, reddish-brown, lace-like macules on the arm

Mentions: A 55-year-old male, presented with 10-year history of persistent itchy lesions all over the body. Physical examination revealed the presence of multiple, discrete waxy papules on an erythematous base on the lower back, thighs, legs and few on the arms. Irregular, reddish-brown, lace-like macules were seen on the outer surface of the arms, back of the neck and around the knees. Erosions and vesicles with hyperkeratosis were intermingled with the lesions on the extremities [Figure 1]. No oral lesions were present. There was no other medical history of note. There was no clinical evidence of systemic infiltration such as organomegaly or macroglossia.


Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations.

Suranagi VV, Siddramappa B, Bannur HB, Patil PV, Davangeri RS - Indian J Dermatol (2015 Jan-Feb)

(a) Multiple, discrete, waxy papules on an erythematous base on the leg, with few vesicles. (b) Irregular, reddish-brown, lace-like macules on the arm
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318037&req=5

Figure 1: (a) Multiple, discrete, waxy papules on an erythematous base on the leg, with few vesicles. (b) Irregular, reddish-brown, lace-like macules on the arm
Mentions: A 55-year-old male, presented with 10-year history of persistent itchy lesions all over the body. Physical examination revealed the presence of multiple, discrete waxy papules on an erythematous base on the lower back, thighs, legs and few on the arms. Irregular, reddish-brown, lace-like macules were seen on the outer surface of the arms, back of the neck and around the knees. Erosions and vesicles with hyperkeratosis were intermingled with the lesions on the extremities [Figure 1]. No oral lesions were present. There was no other medical history of note. There was no clinical evidence of systemic infiltration such as organomegaly or macroglossia.

Bottom Line: Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions.Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence.We report a case with a rare combination of biphasic, bullous variant of familial LA.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, J N Medical College, Belgaum, Karnataka, India.

ABSTRACT
A 55-year-old man presented with multiple, itchy papules and macules on the trunk and extremities. Histopathologic examination of biopsy specimens taken from three different lesions showed a subepidermal blister with amyloid deposits in the dermal papillae. No systemic disease or involvement of other organs was detected. The clinical and histological findings were compatible with a bullous variant of lichen amyloidosis (LA). Primary cutaneous localized amyloidosis usually presents with papular, macular or nodular lesions. Bullous lesions associated with LA are very rare. Furthermore, patient had seven other members in the family with similar lesions, which is also a rare occurrence. We report a case with a rare combination of biphasic, bullous variant of familial LA.

No MeSH data available.


Related in: MedlinePlus