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Genital Ulcerative Pyoderma Gangrenosum in Behçet's Disease: A Case Report and Review of the Literature.

Ozuguz P, Kacar SD, Manav V, Karaca S, Aktepe F, Ulu S - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: Behçet's disease (BD), first described by Hulusi Behcet, is a multisystemic disease characterized by recurrent oral and genital ulcerations, ocular and cutaneous lesions, arthritis and vascular disease.A 33-year-old woman complained a severe genital ulcer.She had a purulent oozing and stinky ulceration on the right side of labium minor measuring 5-8 cm.

View Article: PubMed Central - PubMed

Affiliation: Afyon Kocatepe University Department of Dermatology, Afyon, Turkey.

ABSTRACT
Behçet's disease (BD), first described by Hulusi Behcet, is a multisystemic disease characterized by recurrent oral and genital ulcerations, ocular and cutaneous lesions, arthritis and vascular disease. Pyoderma gangrenosum (PG) is a rare, chronic, sterile pustular and progressive ulcerative process of unknown cause; sometimes can participate in the differential diagnosis of Behcet's ulceration. A 33-year-old woman complained a severe genital ulcer. She had a purulent oozing and stinky ulceration on the right side of labium minor measuring 5-8 cm. A punch biopsy at ulcer margin showed that the lymphocytic panniculitis was extending to the subcutaneous fat tissue without fibrin deposition or necrotic changes in the vessel wall. Based on the clinical and histological findings, she was diagnosed as genital ulcerative PG, which occurred during the exacerbation of BD.

No MeSH data available.


Related in: MedlinePlus

The purulent oozing and stinky ulceration on the right side of labium minor measuring 5-8 cm
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Figure 1: The purulent oozing and stinky ulceration on the right side of labium minor measuring 5-8 cm

Mentions: A 33-year-old woman complained of severe genital ulcer in January 2012. On admission, the patient had painful ulcer on the genital area for the past 10 days with purulent discharge [Figure 1]. She was diagnosed as BD based on criteria of International study group[1] by the presence of pathergy together with oral and genital ulcers in 2004 and treated with colchicine 0.5 mg orally 3 times/day. In 2009, she had diplopia as a result of neurological manifestations of BD and was successfully treated with systemic steroids. There was no evidence for a systemic disease or malignancy. Her family history was positive for BD.


Genital Ulcerative Pyoderma Gangrenosum in Behçet's Disease: A Case Report and Review of the Literature.

Ozuguz P, Kacar SD, Manav V, Karaca S, Aktepe F, Ulu S - Indian J Dermatol (2015 Jan-Feb)

The purulent oozing and stinky ulceration on the right side of labium minor measuring 5-8 cm
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318036&req=5

Figure 1: The purulent oozing and stinky ulceration on the right side of labium minor measuring 5-8 cm
Mentions: A 33-year-old woman complained of severe genital ulcer in January 2012. On admission, the patient had painful ulcer on the genital area for the past 10 days with purulent discharge [Figure 1]. She was diagnosed as BD based on criteria of International study group[1] by the presence of pathergy together with oral and genital ulcers in 2004 and treated with colchicine 0.5 mg orally 3 times/day. In 2009, she had diplopia as a result of neurological manifestations of BD and was successfully treated with systemic steroids. There was no evidence for a systemic disease or malignancy. Her family history was positive for BD.

Bottom Line: Behçet's disease (BD), first described by Hulusi Behcet, is a multisystemic disease characterized by recurrent oral and genital ulcerations, ocular and cutaneous lesions, arthritis and vascular disease.A 33-year-old woman complained a severe genital ulcer.She had a purulent oozing and stinky ulceration on the right side of labium minor measuring 5-8 cm.

View Article: PubMed Central - PubMed

Affiliation: Afyon Kocatepe University Department of Dermatology, Afyon, Turkey.

ABSTRACT
Behçet's disease (BD), first described by Hulusi Behcet, is a multisystemic disease characterized by recurrent oral and genital ulcerations, ocular and cutaneous lesions, arthritis and vascular disease. Pyoderma gangrenosum (PG) is a rare, chronic, sterile pustular and progressive ulcerative process of unknown cause; sometimes can participate in the differential diagnosis of Behcet's ulceration. A 33-year-old woman complained a severe genital ulcer. She had a purulent oozing and stinky ulceration on the right side of labium minor measuring 5-8 cm. A punch biopsy at ulcer margin showed that the lymphocytic panniculitis was extending to the subcutaneous fat tissue without fibrin deposition or necrotic changes in the vessel wall. Based on the clinical and histological findings, she was diagnosed as genital ulcerative PG, which occurred during the exacerbation of BD.

No MeSH data available.


Related in: MedlinePlus