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The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study.

Treesirichod A, Chaithirayanon S, Wongjitrat N, Wattanapan P - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects.The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%.The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Nakhonnayok, Thailand.

ABSTRACT

Aims: To assess the degree of improvement of neck hyperpigmentation in childhood acanthosis nigricans (AN) after treatment with topical 0.1% adapalene gel and the assessment of localized tissue tolerance to the gel.

Subjects and methods: A split comparison study of the hyperpigmentation on the neck was conducted in patients diagnosed with childhood AN. Patients were treated with topical 0.1% adapalene gel for a period of 4 weeks. The skin color of their neck was evaluated at baseline, 2 weeks and 4 weeks using a skin color chart. Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects. The investigator's global evaluation (IGE) scale and the parent's global evaluation (PGE) scale were used to assess the efficacy of the patients' treatment at the end of the 4(th) week.

Results: The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%. The percentage of changes of skin color ratio was consistent with the efficacy evaluations as performed by the IGE and PGE scales. Treatment-related cutaneous irritation was minimal, predominantly in the first 2 weeks of treatment and was shown to be well-tolerated at week 4 following a modification of the treatment regimen.

Conclusions: The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation.

No MeSH data available.


Related in: MedlinePlus

Cutaneous irritation grading scales in the patients (erythema, dryness, peeling, burning, and itching)-0: None, 1: Slight, 2: Mild, 3: Moderate, and 4: Severe
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Figure 3: Cutaneous irritation grading scales in the patients (erythema, dryness, peeling, burning, and itching)-0: None, 1: Slight, 2: Mild, 3: Moderate, and 4: Severe

Mentions: Overall, topical 0.1% adapalene gel was well-tolerated. A total of eight patients (50.0%) experienced cutaneous irritation at week 2 and the incidence decreased to four patients (25%) at week 4 [Table 3] and it was scored as a mild reaction by the end of study on therapeutic side [Figure 3]. There was no cutaneous irritation on the neck applying the placebo. Treatment-related cutaneous irritation was minimal, with signs of slight skin dryness, peeling, erythema, and burning sensation. The highest irritation scores were recorded during the 1st week and subsequently declined throughout the treatment. There was no discontinuation related to cutaneous irritation. One patient had experienced erythema and a burning sensation. The patient was instructed to change the application regimen of the topical 0.1% adapalene to every other day. As a result, the cutaneous irritation gradually improved.


The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study.

Treesirichod A, Chaithirayanon S, Wongjitrat N, Wattanapan P - Indian J Dermatol (2015 Jan-Feb)

Cutaneous irritation grading scales in the patients (erythema, dryness, peeling, burning, and itching)-0: None, 1: Slight, 2: Mild, 3: Moderate, and 4: Severe
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318025&req=5

Figure 3: Cutaneous irritation grading scales in the patients (erythema, dryness, peeling, burning, and itching)-0: None, 1: Slight, 2: Mild, 3: Moderate, and 4: Severe
Mentions: Overall, topical 0.1% adapalene gel was well-tolerated. A total of eight patients (50.0%) experienced cutaneous irritation at week 2 and the incidence decreased to four patients (25%) at week 4 [Table 3] and it was scored as a mild reaction by the end of study on therapeutic side [Figure 3]. There was no cutaneous irritation on the neck applying the placebo. Treatment-related cutaneous irritation was minimal, with signs of slight skin dryness, peeling, erythema, and burning sensation. The highest irritation scores were recorded during the 1st week and subsequently declined throughout the treatment. There was no discontinuation related to cutaneous irritation. One patient had experienced erythema and a burning sensation. The patient was instructed to change the application regimen of the topical 0.1% adapalene to every other day. As a result, the cutaneous irritation gradually improved.

Bottom Line: Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects.The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%.The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Nakhonnayok, Thailand.

ABSTRACT

Aims: To assess the degree of improvement of neck hyperpigmentation in childhood acanthosis nigricans (AN) after treatment with topical 0.1% adapalene gel and the assessment of localized tissue tolerance to the gel.

Subjects and methods: A split comparison study of the hyperpigmentation on the neck was conducted in patients diagnosed with childhood AN. Patients were treated with topical 0.1% adapalene gel for a period of 4 weeks. The skin color of their neck was evaluated at baseline, 2 weeks and 4 weeks using a skin color chart. Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects. The investigator's global evaluation (IGE) scale and the parent's global evaluation (PGE) scale were used to assess the efficacy of the patients' treatment at the end of the 4(th) week.

Results: The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%. The percentage of changes of skin color ratio was consistent with the efficacy evaluations as performed by the IGE and PGE scales. Treatment-related cutaneous irritation was minimal, predominantly in the first 2 weeks of treatment and was shown to be well-tolerated at week 4 following a modification of the treatment regimen.

Conclusions: The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation.

No MeSH data available.


Related in: MedlinePlus