Limits...
The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study.

Treesirichod A, Chaithirayanon S, Wongjitrat N, Wattanapan P - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects.The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%.The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Nakhonnayok, Thailand.

ABSTRACT

Aims: To assess the degree of improvement of neck hyperpigmentation in childhood acanthosis nigricans (AN) after treatment with topical 0.1% adapalene gel and the assessment of localized tissue tolerance to the gel.

Subjects and methods: A split comparison study of the hyperpigmentation on the neck was conducted in patients diagnosed with childhood AN. Patients were treated with topical 0.1% adapalene gel for a period of 4 weeks. The skin color of their neck was evaluated at baseline, 2 weeks and 4 weeks using a skin color chart. Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects. The investigator's global evaluation (IGE) scale and the parent's global evaluation (PGE) scale were used to assess the efficacy of the patients' treatment at the end of the 4(th) week.

Results: The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%. The percentage of changes of skin color ratio was consistent with the efficacy evaluations as performed by the IGE and PGE scales. Treatment-related cutaneous irritation was minimal, predominantly in the first 2 weeks of treatment and was shown to be well-tolerated at week 4 following a modification of the treatment regimen.

Conclusions: The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation.

No MeSH data available.


Related in: MedlinePlus

Felix von Luschan skin color chart
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4318025&req=5

Figure 1: Felix von Luschan skin color chart

Mentions: The skin color at the neck and interscapular areas (assumed as the baseline normal skin color) of all subjects was ranked according to Felix von Luschan's Skin Color chart [Figure 1][9] skin colors were ranged from 1 to 36, by one blinded investigator and were calculated as skin color ratio (skin color ratio = [(skin color at the neck on visit - skin color at the interscapular area)/skin color at the interscapular area] × 100) for each visit. The efficacy of the treatment was determined by the percentage of change of the skin color ratio (week 0 vs. week 4). The investigator's global evaluation (IGE) and parent's global evaluation (PGE) were also used to evaluate the overall success rate. IGE and PGE scales were evaluated on a scale ranging from 0 to 6 [0; clear (100% improvement)], [1; almost cleared (90-99% improvement)], [2; marked improvement (75-89% improvement)], [3; moderate improvement (50-74% improvement)], [4; mild improvement (≤50% improvement)], [5; no change], and [6; worsening].


The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study.

Treesirichod A, Chaithirayanon S, Wongjitrat N, Wattanapan P - Indian J Dermatol (2015 Jan-Feb)

Felix von Luschan skin color chart
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318025&req=5

Figure 1: Felix von Luschan skin color chart
Mentions: The skin color at the neck and interscapular areas (assumed as the baseline normal skin color) of all subjects was ranked according to Felix von Luschan's Skin Color chart [Figure 1][9] skin colors were ranged from 1 to 36, by one blinded investigator and were calculated as skin color ratio (skin color ratio = [(skin color at the neck on visit - skin color at the interscapular area)/skin color at the interscapular area] × 100) for each visit. The efficacy of the treatment was determined by the percentage of change of the skin color ratio (week 0 vs. week 4). The investigator's global evaluation (IGE) and parent's global evaluation (PGE) were also used to evaluate the overall success rate. IGE and PGE scales were evaluated on a scale ranging from 0 to 6 [0; clear (100% improvement)], [1; almost cleared (90-99% improvement)], [2; marked improvement (75-89% improvement)], [3; moderate improvement (50-74% improvement)], [4; mild improvement (≤50% improvement)], [5; no change], and [6; worsening].

Bottom Line: Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects.The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%.The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Nakhonnayok, Thailand.

ABSTRACT

Aims: To assess the degree of improvement of neck hyperpigmentation in childhood acanthosis nigricans (AN) after treatment with topical 0.1% adapalene gel and the assessment of localized tissue tolerance to the gel.

Subjects and methods: A split comparison study of the hyperpigmentation on the neck was conducted in patients diagnosed with childhood AN. Patients were treated with topical 0.1% adapalene gel for a period of 4 weeks. The skin color of their neck was evaluated at baseline, 2 weeks and 4 weeks using a skin color chart. Skin color ratio (the skin on their necks compared with the skin on their backs) was calculated for all subjects. The investigator's global evaluation (IGE) scale and the parent's global evaluation (PGE) scale were used to assess the efficacy of the patients' treatment at the end of the 4(th) week.

Results: The mean skin color ratio of therapeutic side was significantly decreased from the baseline scores, at weeks 2 and 4, respectively (30.1%, 18.3%, and 12.9%, P < 0.001), with marked skin improvement at 60.7% ± 28.5%. The percentage of changes of skin color ratio was consistent with the efficacy evaluations as performed by the IGE and PGE scales. Treatment-related cutaneous irritation was minimal, predominantly in the first 2 weeks of treatment and was shown to be well-tolerated at week 4 following a modification of the treatment regimen.

Conclusions: The study has shown the efficacy of topical 0.1% adapalene gel in the treatment of AN, specifically, in regards to the skin darkening with minimal cutaneous irritation.

No MeSH data available.


Related in: MedlinePlus