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Oral lichenoid lesions - a review and update.

Kamath VV, Setlur K, Yerlagudda K - Indian J Dermatol (2015 Jan-Feb)

Bottom Line: In contrast to the idiopathic nature of OLP, OLLs are often associated with a known identifiable inciting factor.Associations with dental restorative materials, drugs, and medications have been conclusively proven in the etiology of this condition.Substantial differentiating features were uncovered to delineate OLLs as a separate entity with definite etiology, pathogenesis, and a high malignant transformation rate compared with OLP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Dr. Syamala Reddy Dental College, Hospital and Research Centre, Munnekolala, Marathalli, Bangalore, Karnataka, India.

ABSTRACT

Background: Oral lichenoid lesions or reactions (OLLs/OLRs) are clinical and histological contemporaries of the classical oral lichen planus (OLP) that have generated a lot of debate in literature. In contrast to the idiopathic nature of OLP, OLLs are often associated with a known identifiable inciting factor. A superficial examination of these lesions clinically and histologically often reveals many similarities with OLP, but recent data indicate that distinguishable features do exist and form the basis of most classifications.

Aims and objectives: This paper attempts to collate available data in English literature on OLLs, highlight distinguishing features clinically and histologically and reflect on the malignant transformation potential and treatment modalities of the condition.

Materials and methods: A comprehensive search of medical and dental databases including PubMed, Ovid, Cochrane, Pubget, Researchgate, and non-medical search engines were utilized for the review. The search words included "oral lichen planus", "oral lichenoid lesions", "oral drug reactions", "lichenoid dysplasia", and "adverse effects of dental materials".

Review results: OLLs seem to grossly underrated and most cases were clubbed as OLP. Definite clinical and histological features were uncovered to establish the identity of this lesion. Associations with dental restorative materials, drugs, and medications have been conclusively proven in the etiology of this condition. Specific markers are being utilized to diagnose the condition and monitor its progress.

Conclusion: Substantial differentiating features were uncovered to delineate OLLs as a separate entity with definite etiology, pathogenesis, and a high malignant transformation rate compared with OLP.

No MeSH data available.


Related in: MedlinePlus

A more classical oral lichen planus (OLP) like presentation in another case with proximity to amalgam restorations
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Figure 2: A more classical oral lichen planus (OLP) like presentation in another case with proximity to amalgam restorations

Mentions: However, there are certain distinctive features that OLLs exhibit that differentiate them from OLP. OLLs are usually unilateral, have a topographical association with a dental restorative material and a causative association with a drug or medication, if it is the inciting factor, and rarely occur in sites like tongue and palate [Figures 1 and 2]. The causal effect can be confirmed by withdrawal of the suspected drug, if medically feasible, and observation of the regression of the lesion. Occasionally, when dental material association is suspected then epicutaneous patch tests and replacement of the material may bring about the desired result.


Oral lichenoid lesions - a review and update.

Kamath VV, Setlur K, Yerlagudda K - Indian J Dermatol (2015 Jan-Feb)

A more classical oral lichen planus (OLP) like presentation in another case with proximity to amalgam restorations
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4318020&req=5

Figure 2: A more classical oral lichen planus (OLP) like presentation in another case with proximity to amalgam restorations
Mentions: However, there are certain distinctive features that OLLs exhibit that differentiate them from OLP. OLLs are usually unilateral, have a topographical association with a dental restorative material and a causative association with a drug or medication, if it is the inciting factor, and rarely occur in sites like tongue and palate [Figures 1 and 2]. The causal effect can be confirmed by withdrawal of the suspected drug, if medically feasible, and observation of the regression of the lesion. Occasionally, when dental material association is suspected then epicutaneous patch tests and replacement of the material may bring about the desired result.

Bottom Line: In contrast to the idiopathic nature of OLP, OLLs are often associated with a known identifiable inciting factor.Associations with dental restorative materials, drugs, and medications have been conclusively proven in the etiology of this condition.Substantial differentiating features were uncovered to delineate OLLs as a separate entity with definite etiology, pathogenesis, and a high malignant transformation rate compared with OLP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Dr. Syamala Reddy Dental College, Hospital and Research Centre, Munnekolala, Marathalli, Bangalore, Karnataka, India.

ABSTRACT

Background: Oral lichenoid lesions or reactions (OLLs/OLRs) are clinical and histological contemporaries of the classical oral lichen planus (OLP) that have generated a lot of debate in literature. In contrast to the idiopathic nature of OLP, OLLs are often associated with a known identifiable inciting factor. A superficial examination of these lesions clinically and histologically often reveals many similarities with OLP, but recent data indicate that distinguishable features do exist and form the basis of most classifications.

Aims and objectives: This paper attempts to collate available data in English literature on OLLs, highlight distinguishing features clinically and histologically and reflect on the malignant transformation potential and treatment modalities of the condition.

Materials and methods: A comprehensive search of medical and dental databases including PubMed, Ovid, Cochrane, Pubget, Researchgate, and non-medical search engines were utilized for the review. The search words included "oral lichen planus", "oral lichenoid lesions", "oral drug reactions", "lichenoid dysplasia", and "adverse effects of dental materials".

Review results: OLLs seem to grossly underrated and most cases were clubbed as OLP. Definite clinical and histological features were uncovered to establish the identity of this lesion. Associations with dental restorative materials, drugs, and medications have been conclusively proven in the etiology of this condition. Specific markers are being utilized to diagnose the condition and monitor its progress.

Conclusion: Substantial differentiating features were uncovered to delineate OLLs as a separate entity with definite etiology, pathogenesis, and a high malignant transformation rate compared with OLP.

No MeSH data available.


Related in: MedlinePlus